A synapse model for developing somatosensory cortex (Manninen et al 2020)

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Accession:266819
We developed a model for an L4-L2/3 synapse in somatosensory cortex to study the role of astrocytes in modulation of t-LTD. Our model includes the one-compartmental presynaptic L4 spiny stellate cell, two-compartmental (soma and dendrite) postsynaptic L2/3 pyramidal cell, and one-compartmental fine astrocyte process.
Reference:
1 . Manninen T, Saudargiene A, Linne ML (2020) Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Comput Biol 16:e1008360 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Glia;
Brain Region(s)/Organism: Barrel cortex;
Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Astrocyte; Neocortex spiny stellate cell;
Channel(s): Ca pump; I CAN; I Na,p; I_SERCA; I_KD; I A; I K; I N; I L high threshold; I C;
Gap Junctions:
Receptor(s): NMDA; AMPA; IP3; mGluR;
Gene(s):
Transmitter(s): Glutamate; Endocannabinoid;
Simulation Environment: Python;
Model Concept(s): Development; Long-term Synaptic Plasticity; Synaptic Plasticity; Calcium dynamics; STDP;
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]; Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; AMPA; NMDA; mGluR; IP3; I Na,p; I L high threshold; I N; I A; I K; I CAN; I_SERCA; I_KD; Ca pump; I C; Glutamate; Endocannabinoid;
The MIT License (MIT)

Copyright (c) 2020 Tiina Manninen, Ausra Saudargiene, and Marja-Leena Linne

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