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A model for a nociceptor terminal and terminal tree (Barkai et al., 2020)
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This model was used to study how the architecture of the nociceptor terminal tree affects the input-output relation of the primary nociceptive neurons. The model shows that the input-output properties of the nociceptive neurons depend on the length, the axial resistance, and location of individual terminals and that activation of multiple terminals by a capsaicin-like current allows summation of the responses from individual terminals, thus leading to increased nociceptive output.
Barkai O, Butterman R, Katz B, Lev S, Binshtok AM (2020) The Input-Output Relation of Primary Nociceptive Neurons is Determined by the Morphology of the Peripheral Nociceptive Terminals.
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Dorsal Root Ganglion (DRG) cell;
Axonal Action Potentials;
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