Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. 2021)
Download zip file
Help downloading and running models
Model Information
Model File
Citations
Accession:
266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 .
Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons.
J Neurophysiology
125
:1501-1516
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s):
I h;
TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Python;
NetPyNE;
Model Concept(s):
Impedance;
Implementer(s):
Kelley, Craig;
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex M1 L5B pyramidal pyramidal tract GLU cell
;
I h
;
TASK channel
;
/
L5PYR_Resonance-master
models
DuraBernal
mod
ar_traub.mod
*
Other models using ar_traub.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cadad.mod
*
Other models using cadad.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cadyn.mod
*
Other models using cadyn.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cagk.mod
*
Other models using cagk.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
cal_mh.mod
*
Other models using cal_mh.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cal_mig.mod
*
Other models using cal_mig.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
can_mig.mod
*
Other models using can_mig.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
canin.mod
*
Other models using canin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cat_mig.mod
*
Other models using cat_mig.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
cat_traub.mod
*
Other models using cat_traub.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
catcb.mod
*
Other models using catcb.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
gabab.mod
*
Other models using gabab.mod:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
h_BS.mod
*
Other models using h_BS.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
h_harnett.mod
h_kole.mod
*
Other models using h_kole.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
h_migliore.mod
*
Other models using h_migliore.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
HCN1.mod
*
Other models using HCN1.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
hin.mod
*
Other models using hin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
IC.mod
*
Other models using IC.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
ican_sidi.mod
*
Other models using ican_sidi.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
IKsin.mod
*
Other models using IKsin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kap_BS.mod
*
Other models using kap_BS.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kapcb.mod
*
Other models using kapcb.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kapin.mod
*
Other models using kapin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kBK.mod
*
Other models using kBK.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
kctin.mod
*
Other models using kctin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
kdmc_BS.mod
*
Other models using kdmc_BS.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kdr_BS.mod
*
Other models using kdr_BS.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
kdrin.mod
*
Other models using kdrin.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
MyExp2SynBB.mod
*
Other models using MyExp2SynBB.mod:
CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Ih tunes oscillations in an In Silico CA3 model (Neymotin et al. 2013)
In silico hippocampal modeling for multi-target pharmacotherapy in schizophrenia (Sherif et al 2020)
Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
MyExp2SynNMDABB.mod
*
Other models using MyExp2SynNMDABB.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
nafx.mod
*
Other models using nafx.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Fast Spiking Basket cells (Tzilivaki et al 2019)
Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
nap_sidi.mod
*
Other models using nap_sidi.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
nax_BS.mod
*
Other models using nax_BS.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
savedist.mod
*
Other models using savedist.mod:
Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
vecstim.mod
*
Other models using vecstim.mod:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
ghk.inc
*
Other models using ghk.inc:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
misc.h
parameters.multi
*
Other models using parameters.multi:
Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)
File not selected
<- Select file from this column.
Loading data, please wait...
