Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. 2021)

 Download zip file 
Help downloading and running models
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology 125:1501-1516 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
h.mod *
Km.mod *
kv.mod *
Kv1.mod *
na.mod *
nax.mod *
rm KoleCell\[0].apic\[51]-batch.sbatch
rm KoleCell\[0].apic\[52]-batch.sbatch
rm KoleCell\[0].apic\[53]-batch.sbatch
rm KoleCell\[0].apic\[54]-batch.sbatch
rm KoleCell\[0].apic\[55]-batch.sbatch
rm KoleCell\[0].apic\[56]-batch.sbatch
rm KoleCell\[0].apic\[57]-batch.sbatch
rm KoleCell\[0].apic\[58]-batch.sbatch
rm KoleCell\[0].apic\[59]-batch.sbatch
rm KoleCell\[0].apic\[5]-batch.sbatch
rm KoleCell\[0].apic\[60]-batch.sbatch
rm KoleCell\[0].apic\[61]-batch.sbatch
rm KoleCell\[0].apic\[62]-batch.sbatch
rm KoleCell\[0].apic\[63]-batch.sbatch
rm KoleCell\[0].apic\[64]-batch.sbatch
rm KoleCell\[0].apic\[65]-batch.sbatch
rm KoleCell\[0].apic\[66]-batch.sbatch
rm KoleCell\[0].apic\[67]-batch.sbatch
rm KoleCell\[0].apic\[68]-batch.sbatch
rm KoleCell\[0].apic\[69]-batch.sbatch
rm KoleCell\[0].apic\[6]-batch.sbatch
rm KoleCell\[0].apic\[70]-batch.sbatch
rm KoleCell\[0].apic\[71]-batch.sbatch
rm KoleCell\[0].apic\[72]-batch.sbatch
rm KoleCell\[0].apic\[73]-batch.sbatch
rm KoleCell\[0].apic\[74]-batch.sbatch
rm KoleCell\[0].apic\[75]-batch.sbatch
rm KoleCell\[0].apic\[76]-batch.sbatch
rm KoleCell\[0].apic\[77]-batch.sbatch
rm KoleCell\[0].apic\[78]-batch.sbatch
rm KoleCell\[0].apic\[79]-batch.sbatch
rm KoleCell\[0].apic\[7]-batch.sbatch

Loading data, please wait...