Dendritic Impedance in Neocortical L5 PT neurons (Kelley et al. accepted)

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Accession:266851
We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Reference:
1 . Kelley C, Dura-Bernal S, Neymotin SA, Antic SD, Carnevale NT, Migliore M, Lytton WW (2021) Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. J Neurophysiology (accepted)
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I h; TASK channel;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python; NetPyNE;
Model Concept(s): Impedance;
Implementer(s): Kelley, Craig;
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell; I h; TASK channel;
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Kole
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COMMENT

Deterministic model of kinetics and voltage-dependence of Ih-currents
in layer 5 pyramidal neuron, see Kole et al., 2006. Implemented by
Stefan Hallermann.

Predominantly HCN1 / HCN2 

ENDCOMMENT

TITLE Ih-current

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
     (mM) = (milli/liter)

}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	dt 	   		(ms)
	v 	   		(mV)
        ehd=-47 		(mV) 				       
	ghdbar=0.00015 (mho/cm2)	
	gamma_ih	:not used
	seed		:not used
}


NEURON {
	SUFFIX ih
	NONSPECIFIC_CURRENT Iqq
	RANGE Iqq,ghdbar
}

STATE {
	qq
}

ASSIGNED {
	Iqq (mA/cm2)
}

INITIAL {
	qq=alpha(v)/(beta(v)+alpha(v))
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	Iqq = ghdbar*qq*(v-ehd)
}

FUNCTION alpha(v(mV)) {

	alpha = 0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1)
	: parameters are estimated by direct fitting of HH model to
        : activation time constants and voltage activation curve
        : recorded at 34C

}

FUNCTION beta(v(mV)) {
	beta = 0.001*193*exp(v/33.1)			
}

DERIVATIVE state {     : exact when v held constant; integrates over dt step
	qq' = (1-qq)*alpha(v) - qq*beta(v)
}

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