A neurite to measure ePSP and AP amplitude after passive spread (DeMaegd & Stein, 2021)

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Accession:266881
Increasing temperatures overwhelmingly shunts dendritic electrical spread in a crustacean motor neuron (LG) leading to the disruption of a vital pattern generator. LG recieves synaptic input from a descending projection neuron (MCN1) via a chemical and electrical synapse. Warmer temperatures increase leak conductances in the neurite and increase the synaptic input. Here, we modelled the conflicting influence of temperature at the MCN1-LG synapse and LG neurite to determine the resulting ePSP and AP amplitude measured at different distanced from the synaptic input after passive progation through the neurite.
Reference:
1 . DeMaegd ML, Stein W (2021) Neuropeptide modulation increases dendritic electrical spread to restore neuronal activity disrupted by temperature J Neurosci
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Stomatogastric ganglion;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Demaegd, Maggie [mdemaeg at ilstu.edu]; Stein, Wolfgang [wstein@ilstu.edu]; 
There are two distinct models that went into the publication. The first was to measure passive spread of electrical post synaptic potentials (ePSPs). This model has only passive properties, and a current is injected in the "soma" which has all the same properties of the rest of the neurite. 
The second model has a 1000micron axon connected to the 4000micron neurite. The axon has active properties.

Model Parameters changed in the publication

Resistance (gLeak):
0%: 7.3e-5 S
5%: 7.665e-5 S
10%: 8.03e-5 S
15%: 8.39e-5 S
30%: 9.49e-5 S
50%: 1.095e-4 S

Current (IClamp): 
0%: 0.2 nA
5%: 0.21 nA
10%: 0.22 nA
15%: 0.23 nA
30%: 0.26 nA
50%: 0.3 nA

gNa values (in the axon, only AP model): 
0%: 40 mS
5%: 42 mS
10%: 44 mS
15%: 46 mS
30%: 52 mS
50%: 60 mS

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