Reduced-morphology model of CA1 pyramidal cells optimized + validated w/ HippoUnit (Tomko et al '21)

 Download zip file 
Help downloading and running models
Accession:266901
Here we employ the HippoUnit tests to optimize and validate our new compartmental model with reduced morphology. We show that our model is able to account for the following six well-established characteristic anatomical and physiological properties of CA1 pyramidal cells: (1) The reduced dendritic morphology contains all major dendritic branch classes. In addition to anatomy, the model reproduces also 5 key physiological features, including (2) somatic electrophysiological responses, (3) depolarization block, (4) EPSP attenuation (5) action potential (AP) backpropagation, and (6) synaptic integration at oblique dendrites.
Reference:
1 . Tomko M, Benuskova L, Jedlicka P (2021) A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Sci Rep 11:7615 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I h; Ca pump; I K; I K,Ca; I Calcium; I CAN; I M; I Na,t; I A; I_KD; I L high threshold; I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Action Potentials; Active Dendrites; Dendritic Action Potentials; Depolarization block; Parameter Fitting; Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I_KD; Ca pump;
 
/
TomkoEtAl2021
                            
File not selected

<- Select file from this column.
Loading data, please wait...