Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021)

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Accession:266974
We fit a simplified Luo-Rudy model to voltage-clamp data showing a circadian rhythm in L-type calcium conductance. Simulations of the model (single-cell and 2-D spatial versions) suggest that circadian rhythms in early afterdepolarizations may contribute to daily rhythms in cardiac arrhythmias and sudden cardiac death.
Reference:
1 . Diekman CO, Wei N (2021) Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophys J 120:319-333 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac ventricular cell;
Channel(s): I Calcium; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Circadian Rhythms; Action Potentials; Cardiac pacemaking; Bifurcation;
Implementer(s): Diekman, Casey O. [casey.o.diekman at njit.edu];
Search NeuronDB for information about:  I K; I Calcium; 
README file for code associated with the paper "Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model"

Diekman CO and Wei N (2021) Biophysical Journal, https://doi.org/10.1016/j.bpj.2020.11.2264

The equations for the single-cell version of the model are in "diekman_wei_model.m".
Run "reproduceFigure2.m" to produce the plot shown in Figure 2.

The 2-D spatial version of the model can be run with the code "reproduceFigure9B.m" which will reproduce the simulations shown in Figure 9B. See lines 76-79 of this script to adjust parameter settings and reproduce Figures 6 or 9A instead.

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