Model for pancreatic beta-cells (Law et al. 2020)

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Accession:267027
This model is used to explain how chronic stimulation of pancreatic beta-cells can lead to compensation that restores calcium oscillations and electrical bursting.
Reference:
1 . Law NC, Marinelli I, Bertram R, Corbin KL, Schildmeyer C, Nunemaker CS (2020) Chronic stimulation induces adaptive potassium channel activity that restores calcium oscillations in pancreatic islets in vitro. Am J Physiol Endocrinol Metab 318:E554-E563 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I K; I Calcium; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Bursting; Calcium dynamics;
Implementer(s):
Search NeuronDB for information about:  I K; I K,Ca; I Calcium;
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AJP_20
readme.txt
AJP_20.ode
                            
This computer program was used in the publication "Chronic Stimulation
Induces Adaptive Potassium Channel Activity That Restores Calcium
Oscillations in Pancreatic Islets in Vitro", Am. J. Physiol.,
318:E554-E563, 2020. Authors are Nathan C. Law, Isabella Marinelli, 
Richard Bertram, Kathryn L. Corbin, Cara Schildmeyer, and
Craig S. Nunemaker.

Run using XPPAUT, available from
http://www.math.pitt.edu/~bard/xpp/xpp.html

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