Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al accepted)

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Accession:267067
Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modify the distribution of the sodium channel Nav1.2 to recapitulate an increase in excitability observed in ex vivo slice experiments.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s): Neocortex layer 5 pyramidal cell;
Channel(s): I h; I M; I Potassium; I Sodium; I L high threshold; I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.2 SCN2A;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s):
Implementer(s): Ben-Shalom, Roy [rbenshalom at ucdavis.edu]; Kyoung, Henry [hkyoung at berkeley.edu];
Search NeuronDB for information about:  I L high threshold; I T low threshold; I M; I h; I Sodium; I Potassium;
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SprattEtAl2021
Ri Increase
.ipynb_checkpoints
mechanisms
morphology
params
Stims
Volts
README *
.provenance.json *
25% Ri Increase Figures.ipynb *
axon_utils.hoc
biophysics.hoc *
cellinfo.json *
constants.hoc *
creategui.hoc *
createsimulation.hoc *
fit.hoc *
gui.ses *
init.hoc *
LICENSE *
morphology.hoc *
mosinit.hoc *
ringplot.hoc *
run.py *
run_RmpRiTau.py *
runModel.hoc *
template.hoc *
topo_code.hoc *
                            

/*
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OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN
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*/

/*
 * @file morphology.hoc
 * @brief Morphology
 * @author Werner Van Geit @ BBP
 * @date 2015
*/

begintemplate morphology_0fb1ca4724
public morphology

proc morphology(){localobj nl,import
          nl = new Import3d_Neurolucida3()
          nl.quiet = 1
          nl.input("morphology/dend-C060114A2_axon-C060114A5.asc")
          import = new Import3d_GUI(nl, 0)
          import.instantiate($o1)
          }
endtemplate morphology_0fb1ca4724