DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, accepted)

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GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as 2 weeks post mitosis. Parvalbumin and dendrite-targeting somatostatin interneurons activate a5-subunit containing GABAA receptors (a5-GABAARs) in young neurons, which show a voltage dependent conductance profile with increasing conductance around the AP threshold. The present computational models show that the depolarized GABA reversal potential promotes NMDA receptor activation. However, the voltage-dependent conductance of a5-GABAARs in young neurons is crucial for inhibition of AP firing to generate balanced and sparse firing activity.
1 . Lodge M, Hernandez MC, Schulz JM, Bischofberger J (2021) Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent a5-GABAA receptors Cell Reports
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Dentate gyrus;
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I K; I Krp; I Na,t;
Gap Junctions:
Receptor(s): AMPA; GabaA; NMDA;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials; Detailed Neuronal Models; Development; Neurogenesis; Pattern Separation; Synaptic Integration;
Implementer(s): Schulz, Jan M [j.schulz at unibas.ch]; Bischofberger, Josef;
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; GabaA; AMPA; NMDA; I Na,t; I K; I Krp; Gaba; Glutamate;
// Code by Jan M Schulz and Josef Bischofberger, University of Basel, 2019-20.
// Correspondence can be addressed to j.schulz@unibas.ch
// Computational models of young and mature granule cells in
// Lodge, Hernandez, Schulz, and Bischofberger, Cell Reports, 2021.
// The enclosed code distributes glutamertic and GABAergic synapses over the dendritic tree 
// of a stylized granule cell (either mature or young) and tests the effect of voltage-dependent
// versus linear inhibition on NMDA receptor-mediated depolarization and AP output depending on synapse numbers
// To load in the NEURON simulation environment:
// 1. Download and install NEURON (http://www.neuron.yale.edu/neuron/) if needed
// 2. Make sure that Python is installed and, in Windows, that the location of the installation (e.g. C:\Python27) is added 
//    to the System PATH variable (to be found in the Environment Variables under Advanced Settings of System Properties). 
// 3. Compile all .mod files of the simulation directory via mknrndll.
// 4. Modify start_simul.hoc to select one simulation from Fig.5 or 7.
// 5. Start the simulation by running start_simul.

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