RA projection neurons in zebra finches display different levels of resurgent INa through development. This work reports that projection neurons in the adult zebra finch song nucleus RA display: 1) robust high-frequency firing, 2) ultra-short half-width spike waveforms, 3) superfast Na+ current inactivation kinetics and 4) large resurgent Na+ currents (INaR). Dynamic clamping provides evidence of INaR role in neuronal excitability. The model is composed by one gate with an activating and one inactivating particle which describe a transient inward current triggered by neuronal depolarization.
Zemel BM, Nevue AA, Dagostin A, Lovell PV, Mello CV, Gersdorff HV (2021) Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control Nat Commun . [PubMed]