Resurgent sodium transient current in zebra finch RA (Zemel et al., 2021)

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RA projection neurons in zebra finches display different levels of resurgent INa through development. This work reports that projection neurons in the adult zebra finch song nucleus RA display: 1) robust high-frequency firing, 2) ultra-short half-width spike waveforms, 3) superfast Na+ current inactivation kinetics and 4) large resurgent Na+ currents (INaR). Dynamic clamping provides evidence of INaR role in neuronal excitability. The model is composed by one gate with an activating and one inactivating particle which describe a transient inward current triggered by neuronal depolarization.
1 . Zemel BM, Nevue AA, Dagostin A, Lovell PV, Mello CV, Gersdorff HV (2021) Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control Nat Commun . [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Zebra Finch RA projection neuron;
Channel(s): I Sodium;
Gap Junctions:
Simulation Environment: IGOR Pro;
Model Concept(s): Action Potentials; Motor control;
Implementer(s): Dagostin, Andre [dagostia at];
Search NeuronDB for information about:  I Sodium;
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