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Simulations of modulation of HCN channels in L5PCs (Mäki-Marttunen and Mäki-Marttunen, 2022)

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Accession:267293
"... In this work, we build upon existing biophysically detailed models of thick-tufted layer V pyramidal cells and model the effects of over- and under-expression of Ih channels as well as their neuromodulation by dopamine (gain of Ih function) and acetylcholine (loss of Ih function). We show that Ih channels facilitate the action potentials of layer V pyramidal cells in response to proximal dendritic stimulus while they hinder the action potentials in response to distal dendritic stimulus at the apical dendrite. We also show that the inhibitory action of the Ih channels in layer V pyramidal cells is due to the interactions between Ih channels and a hot zone of low voltage-activated Ca2+ channels at the apical dendrite. Our simulations suggest that a combination of Ih-enhancing neuromodulation at the proximal apical dendrite and Ih-inhibiting modulation at the distal apical dendrite can increase the layer V pyramidal excitability more than any of the two neuromodulators alone..."
Reference:
1 . Mäki-Marttunen T, Mäki-Marttunen V (2022) Excitatory and inhibitory effects of HCN channel modulation on excitability of layer V pyramidal cells Plos Comp Biol [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex layer 5 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Acetylcholine; Dopamine; Glutamate; Gaba;
Simulation Environment: NEURON;
Model Concept(s): Neuromodulation;
Implementer(s): Maki-Marttunen, Tuomo [tuomomm at uio.no];
Search NeuronDB for information about:  AMPA; NMDA; Gaba; Acetylcholine; Dopamine; Gaba; Glutamate;
#Assume the following lines were run from runfig2.sh - the results from these runs are needed for Fig. 5
#for Ihcoeff in 1.0 0.0
#do
#  for dist in `seq 50.0 50.0 1000.0`
#  do
#    echo "python3 strongdendstim_findthresh_absbound.py $Ihcoeff $dist"
#    python3 strongdendstim_findthresh_absbound.py $Ihcoeff $dist
#    echo "python3 strongdendstimcond_findthresh_absbound.py $Ihcoeff $dist"
#    python3 strongdendstimcond_findthresh_absbound.py $Ihcoeff $dist
#  done
#done

for Ihcoeff in 1.0 0.0
do
  for dist in `seq 50 50 1000`
  do
    echo "python3 strongdendstim_findthresh_absbound_withbasalcond.py $Ihcoeff $dist 0.1 50.0 0.0"
    python3 strongdendstim_findthresh_absbound_withbasalcond.py $Ihcoeff $dist 0.1 50.0 0.0
    echo "python3 strongdendstim_findthresh_absbound_withbasalcond.py $Ihcoeff $dist 5.0 50.0 -80.0"
    python3 strongdendstim_findthresh_absbound_withbasalcond.py $Ihcoeff $dist 5.0 50.0 -80.0
  done
done

for myseed in `seq 1 41`
do
  for Ihcoeff in 1.0 0.0
  do
    for dist1 in `seq 200 100 1200`
    do
      for dist2 in `seq $((dist1+100)) 100 1300`
      do
        echo "python3 calcffthreshs_givendists_withbasal.py $Ihcoeff $dist1 $dist2 0.8 0.0 $myseed"
	python3 calcffthreshs_givendists_withbasal.py $Ihcoeff $dist1 $dist2 0.8 0.0 $myseed
        echo "python3 calcffthreshs_givendists_withunijitterbasalgaba.py $Ihcoeff $dist1 $dist2 0.0002 25.0 $myseed"
	python3 calcffthreshs_givendists_withunijitterbasalgaba.py $Ihcoeff $dist1 $dist2 0.0002 25.0 $myseed
      done
    done
  done
done


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