Depolarization Enhacement of Dendritic Spike Propagation (Bock et al 2022)

 Download zip file 
Help downloading and running models
This model shows that small subthreshold depolarization of the soma powerfully enhances the propagation of dendritic spikes, through inactivation of dendritic A-type potassium channels.
1 . Bock T, Negrean A, Siegelbaum AS (2022) Somatic depolarization enhances hippocampal CA1 dendritic spike propagation and distal input-driven synaptic plasticity Journal of Neuroscience [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I R; I T low threshold; I A; I h; I K; I K,Ca;
Gap Junctions:
Simulation Environment: NEURON; Python;
Model Concept(s): Calcium dynamics; Synaptic Plasticity;
Implementer(s): Negrean, Adrian [negreanadrian at]; Bock, Tobias [htb2110 at];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I T low threshold; I A; I K; I h; I K,Ca; I R;
Loading data, please wait...