A modified Morris-Lecar with TRPC4 & GIRK (Tian et al. 2022)

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Simulates differential activation of TRPC4 and GIRK channel to reproduce various spiking patterns underlying Gq/11–Gi/o coincidence signals. The attached code reproduces Fig.5B-F in Tian et al. 2022. Please see readme.txt to get started.
1 . Tian J, Yang J, Joslin WC, Flockerzi V, Prescott SA, Birnbaumer L, Zhu MX (accepted) TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11–Gi/o coincidence signals of variable strengths PNAS
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Abstract Morris-Lecar neuron;
Channel(s): I_AHP; I CAN; I Calcium;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Bursting; Action Potentials; Signaling pathways; Activity Patterns;
Implementer(s): Yang, Jane;
Search NeuronDB for information about:  I CAN; I Calcium; I_AHP;
Code for Tian et al. 2022

gridsearch.m - Runs a gridsearch for the specified number of datapoints for gTRPC4 and gGIRK
mML_TRPC_GIRK.m - the neuron model called in gridsearch.m. Takes gmax values of gTRPC4 and gGIRK as input parameters
quantification_pause_tau - reproduces Fig5B-F in Tian et al. 2022

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