A modified Morris-Lecar with TRPC4 & GIRK (Tian et al. 2022)

 Download zip file 
Help downloading and running models
Simulates differential activation of TRPC4 and GIRK channel to reproduce various spiking patterns underlying Gq/11–Gi/o coincidence signals. The attached code reproduces Fig.5B-F in Tian et al. 2022. Please see readme.txt to get started.
1 . Tian J, Yang J, Joslin WC, Flockerzi V, Prescott SA, Birnbaumer L, Zhu MX (accepted) TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11–Gi/o coincidence signals of variable strengths PNAS
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Abstract Morris-Lecar neuron;
Channel(s): I_AHP; I CAN; I Calcium;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Bursting; Action Potentials; Signaling pathways; Activity Patterns;
Implementer(s): Yang, Jane;
Search NeuronDB for information about:  I CAN; I Calcium; I_AHP;
% Last updated: Apr 27th, 2022
% Grid search of gTRPC4 x gGIRK

clc; clear all; close all; 

x_n_pts = 21; 
y_n_pts = 21; 

gTRPC4 = linspace(0,5,x_n_pts);
gGIRK = linspace(0,5,y_n_pts);

time = 8.5e+3;
dt = 0.01;

[ggirk,gtrpc4] = ndgrid(gGIRK,gTRPC4);
spikes = zeros(y_n_pts,x_n_pts,time/dt);

for x = 1:numel(gTRPC4)
    for y = 1:numel(gGIRK)
        spikes(y,x,:) = mML_TRPC_GIRK(gTRPC4(x),gGIRK(y));
    fprintf([num2str(x/x_n_pts*100),' %%\n'])

FileName=[datestr(now, 'yyyymmdd'),'_20x20-gridsearch_steadystates-gCa=p02_time=8p5_range=0-5.mat'];


Loading data, please wait...