Action potential initiation in the olfactory mitral cell (Shen et al 1999)

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Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact if you have any questions about the implementation of the model.
1 . Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I Na,t; I K; I Sodium; I Potassium;
To simulate the electrode we add a small section to
serve as the electrode resistance and capacitance

watch out when changing Ra in the model since this
electrode.Ra is used for the series resistance!

begintemplate Electrode

public electrode
create electrode

// c (pf) = cm*area = PI*L*diam*(.01) * cm
// rs (MOhm) = Ra*L/2 / (PI*diam^2/4) = 2*L/PI/diam^2 * (.01) * Ra

// so it is nice to have
// PI*L*diam*.01 = 1
// 2*L/PI/diam^2*.01 = 1

// diam = (2/PI^2)^(1/3)
// L = 1/.01/PI/diam

proc init_electrode() {
	electrode {
		diam = (2/PI^2)^(1/3)
		L = 1/.01/PI/diam
		insert pas
		g_pas = 0
		e_pas = 0

proc init() {
        electrode Ra = 0.001		//(Ohm*cm)
        electrode cm = 0		//(uF/cm2)
        connect electrode(0), $1

//electrode makeppm()

endtemplate Electrode

objref se,pe,te

soma se=new Electrode(0.5)
priden[0] pe=new Electrode(1)
se.electrode.Ra = 1.2 = 1e-6
pe.electrode.Ra = 17.5 = 2.95

access soma

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