Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)

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Accession:34163
Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K+ current (IK,A), sustained Ca2+ current (ICa,S), Ca-dependent K+ current (IK,Ca), and a hyperpolarization-activated inward rectifier current (Ih). In this study,we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. See paper for results and more details.
Reference:
1 . Cai Y, Baxter DA, Crow T (2003) Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT. J Comput Neurosci 15:105-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hermissenda photoreceptor Type B;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Serotonin;
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Action Potentials; Invertebrate;
Implementer(s): Cai, Yidao;
Search NeuronDB for information about:  I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow; Serotonin;
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Cai
readme.txt
00note.txt
axona.neu
axona2axonb.es
axonb.neu
axonb2axonc.es
axonc.neu
axonc2term.es
bph.ntw
bph.ntw_genp
bph.ous
bph.ous_bak
bph.ous_genp
bph.ous_mod
bph.ous_Ri
bph.ous_sp
bph.ous_vclamp
bph.ous2
bph.ous3
bph.ous4
bph.smu
bph.trt
bph.trt_casmod
bph.trt_Drmod
bph.trt_Iamod
bph.trt_Ihmod
bph.trt_Ikcamod
bph.trt_light
bph.trt_mixmod
bph.trt_Ri
bph.trt_std
bph.trt_vclamp
bph.trt0
bph_casmod.smu
bph_Drmod.smu
bph_genp.smu
bph_Iamod.smu
bph_Ihmod.smu
bph_Ikcamod.smu
bph_mixmod.smu
bph_Ri.smu
bph_stdmod.smu
ca.A
ca.B
Ca.ion
ca.vdg *
Ca2Ikca.fBR
cat.A
cat.B
cat.vdg
design.txt
Dr.A
Dr.B
Dr.vdg
exp.es
exp1.fnc
exp2.fnc
exp3.fnc
grf.def
Ia.A
Ia.A_bak
Ia.B
Ia.vdg
Ikca.A
Ikca.B
Ikca.vdg *
Ir.A
Ir.vdg
leak.vdg
mv.neu
mv2soma.es
mvleak.vdg
Na.A
Na.B *
Na.vdg
ousgrf.def
simufiles.usd
soma.neu
soma2axona.es
tCa.ion
tca.vdg *
tCa2Ikca.fBR
tcat.vdg *
tDr.vdg
term.neu
term.neu_bak
tIa.vdg
tIkca.vdg *
tIr.vdg
tleak.vdg
tmp.1
tmp.ps
tNa.A
tNa.B
tNa.vdg
treatment.fnc
xaleak.vdg
xbCa.ion *
xbca.vdg *
xbCa2Ikca.fBR
xbcat.vdg *
xbDr.vdg *
xbIa.vdg *
xbIkca.vdg *
xbIr.vdg
xbleak.vdg
xbNa.A *
xbNa.B *
xbNa.vdg *
xcCa.ion *
xcca.vdg *
xcCa2Ikca.fBR
xccat.vdg *
xcDr.vdg *
xcIa.vdg *
xcIkca.vdg *
xcIr.vdg
xcleak.vdg
xcNa.A *
xcNa.B *
xcNa.vdg *
                            
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		>>    MODELE NAME: neu		>>
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>------------------------------->--------------------------------------->
   THRESHOLD:	0.0       	> Threshold for transmitter release	>
>------------------------------->--------------------------------------->
   SPIKDUR:	0.0       	> Spike duration. If equal 0 then	>
				>	actual time when presynaptic	>
				>	neuronis above threshold will	>
				>	be measured			>
>------------------------------->--------------------------------------->
   VMINIT:	-60.0     	> Initial value of membrane potential.	>
>------------------------------->--------------------------------------->
   CM:		0.00000785    	> Membrane capacitance.			>
>   CM:		0.0000157    	> Membrane capacitance.			>
>   CM:		0.0000314    	> Membrane capacitance.			>
>------------------------------->--------------------------------------->

>------------------------------->--------------------------------------->
   MEM_AREA:        		> Membrane Area options                 >
>------------------------------->--------------------------------------->
>	0			> type 0, do not use membrane area	>
>------------------------------->--------------------------------------->
>	1			> type 1, specify membrane area directly>
>	5.0             >S<     > um2					>
>------------------------------->--------------------------------------->
>	2			> type 2, sphere			>
>	20.0            >D<     > um, diameter				>
>------------------------------->--------------------------------------->
	3			> type 3, cylinder			>
	5.0             >D<     > um, diameter				>
	50.0           >L<     > um, length				>
	0		>n<     > number of ends closed 		>
>------------------------------->--------------------------------------->
>	current membrane area is	0.00000785    cm*cm		>
>------------------------------->--------------------------------------->


>------------------------------->------------------------------->
   CONDUCTANCES:		>	List of Conductances	>
>------------------------------->------------------------------->
>	Ikca			>	Name of conductance	>
>	xaIkca.vdg		>	File Name		>
>	blue			>	Color			>
>------------------------------->------------------------------->
>	Transient		>	Name of conductance	>
>	xacat.vdg		>	File Name		>
>	red			>	Color			>
>------------------------------->------------------------------->
>	IR			>	Name of conductance	>
>	xaIr.vdg		>	File Name		>
>	purple			>	Color			>
>------------------------------->------------------------------->
>	A			>	Name of conductance	>
>	xaIa.vdg		>	File Name		>
>	blue			>	Color			>
>------------------------------->------------------------------->
>	delayed			>	Name of conductance	>
>	xaDr.vdg		>	File Name		>
>	brown			>	Color			>
>------------------------------->------------------------------->
>	sustained		>	Name of conductance	>
>	xaca.vdg		>	File Name		>
>	white			>	Color			>
>------------------------------->------------------------------->
	leak			>	Name of conductance	>
	xaleak.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
>	Na			>	Name of conductance	>
>	xaNa.vdg		>	File Name		>
>	green			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->


>------------------------------->------------------------------->
>  LIST_ION:			>	List of Ion pools	>
>------------------------------->------------------------------->
>	Ca			>	Name of Ion		>
>	xaCa.ion		>	File Name		>
>	blue			>	Color			>
>------------------------------->------------------------------->
>	END			>				>
>------------------------------->------------------------------->


>------------------------------->--------------------------------------->
> CURRENT_TO_ION:		>	List of current contributing	>
>				>		to ion pools		>
>------------------------------->--------------------------------------->
>	Transient		>	Name of Conductance		>
>	Ca			>	Name of Ion			>
>	blue			>	Color				>
>------------------------------->--------------------------------------->
>	sustained		>	Name of Conductance		>
>	Ca			>	Name of Ion			>
>	blue			>	Color				>
>------------------------------->--------------------------------------->
>	END			>					>
>------------------------------->--------------------------------------->


>------------------------------->--------------------------------------->
>  COND_BY_ION:			>	Regulation of V-dep		>
>				>	conductances by ion pools	>
>------------------------------->--------------------------------------->
>	Ikca			>	Name of Conductance		>
>	Ca			>	Name of Ion			>
>	xaCa2Ikca.fBR		>	File Name			>
>	blue			>	Color				>
>------------------------------->--------------------------------------->
>	END			>					>
>------------------------------->--------------------------------------->


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