CN pyramidal fusiform cell (Kanold, Manis 2001)

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Accession:37856
Pyramidal cells in the dorsal cochlear nucleus (DCN) show three characteristic discharge patterns in response tones: pauser, buildup, and regular firing. Experimental evidence suggests that a rapidly inactivating K+ current (I(KIF)) plays a critical role in generating these discharge patterns. To explore the role of I(KIF), we used a computational model based on the biophysical data. The model replicated the dependence of the discharge pattern on the magnitude and duration of hyperpolarizing prepulses, and I(KIF) was necessary to convey this dependence. Experimentally, half-inactivation voltage and kinetics of I(KIF) show wide variability. Varying these parameters in the model ... suggests that pyramidal cells can adjust their sensitivity to different temporal patterns of inhibition and excitation by modulating the kinetics of I(KIF). Overall, I(KIF) is a critical conductance controlling the excitability of DCN pyramidal cells. (See readme.txt and paper for details). Any questions regarding these implementations should be directed to: pmanis@med.unc.edu 2 April 2004 Paul B Manis, Ph.D.
References:
1 . Kanold PO, Manis PB (2001) A physiologically based model of discharge pattern regulation by transient K+ currents in cochlear nucleus pyramidal cells. J Neurophysiol 85:523-38 [PubMed]
2 . Kanold PO, Manis PB (1999) Transient potassium currents regulate the discharge patterns of dorsal cochlear nucleus pyramidal cells. J Neurosci 19:2195-208 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cochlear nucleus pyramidal/fusiform GLU cell;
Channel(s): I K; I h; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Synaptic Integration;
Implementer(s): Manis, Paul B [PManis at med.unc.edu];
Search NeuronDB for information about:  Cochlear nucleus pyramidal/fusiform GLU cell; I K; I h; I Sodium; I Potassium; 
README.txt

The set of .mod files and the hoc file included here implement the models
described for dorsal cochlear nucleus neurons (pyramidal cells) in the series of
papers by Kanold and Manis (hereafter referred to as K&M - 1999 and 2001).
The equations for each channel type are implemented in the pyr.mod file. The
Ikif and Ikis channel type models are based on experimentally determined
parameters (K&M 1999b). The models for Ina and Ih are based on model
previously described in the literature.

The file pyr.hoc reproduces traces in Figures 2, 3, 4 and 10 of K&M, 2001. The
original figures were run by programs implemented in C++, and exectued as a MEX
file under MATLAB, and these figures are confirmed in NEURON. The small
differences in the figures may arise from the different integration methods, or
from small differences in the initial conditions for the models in the different
simulation environments. For instance, the whole cell input resistance at rest
is 284 Mohms in the MATLAB model, and 300 Mohms in the NEURON model, though it
has been rescaled in this implementation.

Any questions regarding these implementations should be directed to:
pmanis@med.unc.edu

2 April 2004
Paul B Manis, Ph.D.

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