Cardiac Atrial Cell (Courtemanche et al 1998)

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Accession:3800
Marc Courtemanche, Rafael J. Ramirez, and Stanley Nattel. Ionic mechanisms underlying human atrial action potential properties insights from a mathematical model Am J Physiol Heart Circ Physiol 1998 275: H301-H321. The implementation of this model in NEURON was contributed by Ingemar Jacobson.
Reference:
1 . Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Heart cell;
Channel(s): I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
Gap Junctions:
Receptor(s):
Gene(s): Kv4.3 KCND3; Kv1.5 KCNA5; HERG KCNH2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Heart disease; Calcium dynamics;
Implementer(s): Jacobson, Ingemar [Ingemar.Jacobson at astrazeneca.com];
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I Sodium; I Calcium; I Potassium; Na/Ca exchanger;
TITLE Cardiac time independent inward rectifier IK1  current
:   from Courtemanche et al Am J Physiol 1998 275:H301


NEURON {
	SUFFIX IK1
	USEION k READ ek WRITE ik
	RANGE gK1, ik
	GLOBAL dummy : prevent vectorization for use with CVODE

}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)
	 

}

PARAMETER {
	 gK1=0.1567e-3 (S/cm2) <0,1e9>
	
}


ASSIGNED {
	v (mV)
    	ik (mA/cm2)
	ek (mV)
	dummy
	      
}

LOCAL k
BREAKPOINT {
	
	ik = gK1/(1 + exp(0.07*(v + 80)))*(v - ek)
}





             

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