Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
// Cerebellum Granular Cell Model
// Last revised by Fontana Andrea 5.2.1999 
// Last revised by Nieus Thierry 11.1.2001 


 General settings
v_init = -80
tstop = 1000 //for IClamp
//tstop = 50 //for VClamp
dt = 0.025
celsius = 30 

 Single compartment cell
create soma 
soma { 
	nseg = 1 
	diam = 9.76 
	L = 9.76 
	cm = 1
	Ra = 100

Area = PI*soma.diam*soma.L*1e-8

access soma

insert GrC_Lkg1
insert GrG_Na
insert GrG_Nar
insert GrG_KV 
insert GrC_KA 
insert GrC_Kir 
insert GrC_KCa
insert GrC_CaHVA 
insert Calc
insert GrC_pNa
insert GrG_KM
insert GrC_Lkg2

usetable_GrG_Na = 0
usetable_GrC_pNa = 0
usetable_GrC_CaHVA = 0
usetable_GrG_KV = 0
usetable_GrC_KA = 0
usetable_GrC_Kir = 0
usetable_GrC_KCa = 0
usetable_GrG_KM = 0

ena = 87.39
ek = -84.69
eca = 129.33
ecl = -65

 Current clamps

objectvar stim0, stim

Sinusoidal Pulse
objectvar sinu

 Start GUI


// Current clamp
 Procedures to record data in files...
objref tvec, data, file, vettintegra, vettore
tvec = new Vector()
data = new Vector()

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