Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
objref h7
h7 = new HBox()
xvalue("Del (ms)","stim.del", 1,"", 0, 0 )
xvalue("Dur (ms)","stim.dur", 1,"", 0, 0 )
xvalue("Amp (nA)","stim.amp", 1,"", 0, 0 )

h7.map("Step IClamp 2")

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