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Medial vestibular neuron models (Quadroni and Knopfel 1994)

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Accession:53876
The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. The emergence of oscillatory firing under these two specific experimental conditions is consistent with electrophysiological recordings not used during construction of the model. We, therefore, suggest that these models have a high predictive value.
Reference:
1 . Quadroni R, Knöpfel T (1994) Compartmental models of type A and type B guinea pig medial vestibular neurons. J Neurophysiol 72:1911-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Vestibular neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Action Potentials; Calcium dynamics;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; 
//Begin CellBuild[0]
{
load_file("celbild.hoc", "CellBuild")
}
{ocbox_ = new CellBuild(1)}
{object_push(ocbox_)}
{
version(5.7)
continuous = 1
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "dendA"
objref tobj
}
{
tobj = new CellBuildSection("somaA",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(0,0,15,0) tobj.lx=-8.16857 tobj.ly=40.5446 tobj.i3d=0
tobj = new CellBuildSection("dendA",0, 0, tobj, 0) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(0,0,-90,-15) tobj.lx=-81.2966 tobj.ly=14.094 tobj.i3d=0
tobj = new CellBuildSection("dendA",1, 0, tobj, 0) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(0,0,0,-75) tobj.lx=-50.1783 tobj.ly=-46.5867 tobj.i3d=0
tobj = new CellBuildSection("dendA",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(15,0,105,-15) tobj.lx=103.857 tobj.ly=14.094 tobj.i3d=0
tobj = new CellBuildSection("dendA",3, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(1)
  tobj.position(-90,-15,-150,-60) tobj.lx=-194.319 tobj.ly=-42.4781 tobj.i3d=0
tobj = new CellBuildSection("dendA",4, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(1)
  tobj.position(-90,-15,-90,-75) tobj.lx=-138.306 tobj.ly=-81.376 tobj.i3d=0
tobj = new CellBuildSection("dendA",5, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(2)
  tobj.position(0,-75,-45,-120) tobj.lx=-66.7342 tobj.ly=-159.05 tobj.i3d=0
tobj = new CellBuildSection("dendA",6, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(2)
  tobj.position(0,-75,45,-120) tobj.lx=64.9595 tobj.ly=-144.05 tobj.i3d=0
tobj = new CellBuildSection("dendA",7, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(3)
  tobj.position(105,-15,90,-75) tobj.lx=137.528 tobj.ly=-66.376 tobj.i3d=0
tobj = new CellBuildSection("dendA",8, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(3)
  tobj.position(105,-15,150,-45) tobj.lx=194.538 tobj.ly=-22.8103 tobj.i3d=0
all_init()
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{ tobj = snlist.object(0)}
{tobj = new SNList("soma") snlist.append(tobj)}
for i=0,-1 tobj.add(bild.topol.slist.object(fscan()))
{tobj = new SNList("alldendrites") snlist.append(tobj)}
for i=0,8 tobj.add(bild.topol.slist.object(fscan()))
1
2
3
4
5
6
7
8
9
{tobj = new SNList("proximalA") snlist.append(tobj)}
for i=0,2 tobj.add(bild.topol.slist.object(fscan()))
1
2
3
{tobj = new SNList("distalA") snlist.append(tobj)}
for i=0,5 tobj.add(bild.topol.slist.object(fscan()))
4
5
6
7
8
9
{consist()}
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(2)
tobj.value = 31
bild.subsets.snlist.object(1).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 31
bild.subsets.snlist.object(1).geo.append(tobj)
tobj = new GeoSpec(2)
tobj.value = 99
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 3
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 3
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(2)
tobj.value = 198
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 1
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 6
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(2)
tobj.value = 31
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 31
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 1
bild.topol.slist.object(0).geo.append(tobj)
set_default()
}
{object_pop()}
{
}
{object_push(memb)}
{first=0}
{
tobj = new FakeMechStan(0)
tobj.value = 150
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new FakeMechStan(1)
tobj.value = 1
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("gbar_na", 0.020172, 0)
tobj.set("Erev_na", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("nap")
tobj.set("gbar_nap", 3.3e-05, 0)
tobj.set("Erev_nap", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("h")
tobj.set("gbar_h", 0.00011, 0)
tobj.set("Erev_h", -46, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("akfast")
tobj.set("gbar_akfast", 0.024073, 0)
tobj.set("Erev_akfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("ahp")
tobj.set("gbar_ahp", 0.002167, 0)
tobj.set("Erev_ahp", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("kslow")
tobj.set("gbar_kslow", 0.000298, 0)
tobj.set("Erev_kslow", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("a")
tobj.set("gbar_a", 0.001829, 0)
tobj.set("Erev_a", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.00111, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 3.02e-05, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 5.96e-05, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("caleak")
tobj.set("g_caleak", 1.33e-06, 0)
tobj.set("Erev_caleak", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 0.0001328, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_soma")
tobj.set("B_ca_soma", 0.025, 0)
tobj.set("K2f_ex_ca_soma", 3.3e-13*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_soma", 2.65e-09*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("nmda")
tobj.set("gbar_nmda", 0.00257, 0)
tobj.set("Erev_nmda", 0, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(2).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("gbar_na", 0.006667, 0)
tobj.set("Erev_na", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("nap")
tobj.set("gbar_nap", 3.22e-05, 0)
tobj.set("Erev_nap", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 8.8e-07, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("kslow")
tobj.set("gbar_kslow", 0.00024, 0)
tobj.set("Erev_kslow", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 4.6e-06, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.0008, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("h")
tobj.set("gbar_h", 0.00011, 0)
tobj.set("Erev_h", -46, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 1.25e-06, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("caleak")
tobj.set("g_caleak", 6e-08, 0)
tobj.set("Erev_caleak", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("a")
tobj.set("gbar_a", 0.000427, 0)
tobj.set("Erev_a", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("akfast")
tobj.set("gbar_akfast", 0.00648, 0)
tobj.set("Erev_akfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_prox")
tobj.set("B_ca_prox", 0.025, 0)
tobj.set("K2f_ex_ca_prox", 3.21e-13*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_prox", 6.43e-10*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("akfast")
tobj.set("gbar_akfast", 0.00243, 0)
tobj.set("Erev_akfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.00035, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 8.8e-07, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 1.25e-06, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 4.6e-06, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_dist")
tobj.set("B_ca_dist", 0.025, 0)
tobj.set("K2f_ex_ca_dist", 4.85e-13*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_dist", 9.6e-11*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("ahp")
tobj.set("gbar_ahp", 0.002167, 0)
tobj.set("Erev_ahp", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("akfast")
tobj.set("gbar_akfast", 0.024073, 0)
tobj.set("Erev_akfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("a")
tobj.set("gbar_a", 0.001829, 0)
tobj.set("Erev_a", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("caleak")
tobj.set("g_caleak", 1.33e-06, 0)
tobj.set("Erev_caleak", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_soma")
tobj.set("B_ca_soma", 0.025, 0)
tobj.set("K2f_ex_ca_soma", 3.3e-13*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_soma", 2.65e-09*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 5.96e-05, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("h")
tobj.set("gbar_h", 0.00011, 0)
tobj.set("Erev_h", -46, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.00111, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 0.0001328, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("kslow")
tobj.set("gbar_kslow", 0.000298, 0)
tobj.set("Erev_kslow", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 3.02e-05, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("gbar_na", 0.020172, 0)
tobj.set("Erev_na", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("nap")
tobj.set("gbar_nap", 3.3e-05, 0)
tobj.set("Erev_nap", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.topol.slist.object(0).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
output_index = 0  output_x = 1
}
{object_pop()}
{
cexport()
}
{object_pop()}
{
save_window_=ocbox_.gtopol
save_window_.size(-200,200,-150,150)
scene_vector_[2] = save_window_
ocbox_.gtopol = save_window_
save_window_.save_name("ocbox_.gtopol")
}
{
ocbox_.map("CellBuild[0]", 406, 130, 850.56, 676.8)
}
objref ocbox_
//End CellBuild[0]

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