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Medial vestibular neuron models (Quadroni and Knopfel 1994)

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Accession:53876
The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. The emergence of oscillatory firing under these two specific experimental conditions is consistent with electrophysiological recordings not used during construction of the model. We, therefore, suggest that these models have a high predictive value.
Reference:
1 . Quadroni R, Knöpfel T (1994) Compartmental models of type A and type B guinea pig medial vestibular neurons. J Neurophysiol 72:1911-24 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Vestibular neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Action Potentials; Calcium dynamics;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  NMDA; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; 
//Begin CellBuild[1]
{
load_file("celbild.hoc", "CellBuild")
}
{ocbox_ = new CellBuild(1)}
{object_push(ocbox_)}
{
version(5.7)
continuous = 1
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "dendB"
objref tobj
}
{
tobj = new CellBuildSection("somaB",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(0,0,15,0) tobj.lx=-5.05674 tobj.ly=40.5446 tobj.i3d=0
tobj = new CellBuildSection("dendB",0, 0, tobj, 0) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(0,0,-105,0) tobj.lx=-56.402 tobj.ly=15.6499 tobj.i3d=0
tobj = new CellBuildSection("dendB",1, 0, tobj, 0) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(0,0,-60,-45) tobj.lx=-71.9611 tobj.ly=-15.4684 tobj.i3d=0
tobj = new CellBuildSection("dendB",2, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(15,0,45,-60) tobj.lx=1.16694 tobj.ly=-43.4748 tobj.i3d=0
tobj = new CellBuildSection("dendB",3, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(0)
  tobj.position(15,0,90,0) tobj.lx=60.2917 tobj.ly=20.3177 tobj.i3d=0
tobj = new CellBuildSection("dendB",4, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(1)
  tobj.position(-105,0,-165,15) tobj.lx=-149.757 tobj.ly=40.5446 tobj.i3d=0
tobj = new CellBuildSection("dendB",5, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(1)
  tobj.position(-105,0,-165,-30) tobj.lx=-185.543 tobj.ly=-1.46512 tobj.i3d=0
tobj = new CellBuildSection("dendB",6, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(2)
  tobj.position(-60,-45,-120,-60) tobj.lx=-166.872 tobj.ly=-68.3695 tobj.i3d=0
tobj = new CellBuildSection("dendB",7, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(2)
  tobj.position(-60,-45,-45,-90) tobj.lx=-68.8493 tobj.ly=-104.156 tobj.i3d=0
tobj = new CellBuildSection("dendB",8, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(3)
  tobj.position(45,-60,30,-105) tobj.lx=30.7293 tobj.ly=-122.827 tobj.i3d=0
tobj = new CellBuildSection("dendB",9, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(3)
  tobj.position(45,-60,105,-75) tobj.lx=139.643 tobj.ly=-96.376 tobj.i3d=0
tobj = new CellBuildSection("dendB",10, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(4)
  tobj.position(90,0,120,-45) tobj.lx=161.426 tobj.ly=-51.2544 tobj.i3d=0
tobj = new CellBuildSection("dendB",11, 0, tobj, 1) slist.append(tobj)
tobj.parent=slist.object(4)
  tobj.position(90,0,150,15) tobj.lx=197.212 tobj.ly=42.1005 tobj.i3d=0
all_init()
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{ tobj = snlist.object(0)}
{tobj = new SNList("soma") snlist.append(tobj)}
for i=0,0 tobj.add(bild.topol.slist.object(fscan()))
0
{tobj = new SNList("alldendrites") snlist.append(tobj)}
for i=0,11 tobj.add(bild.topol.slist.object(fscan()))
1
2
3
4
5
6
7
8
9
10
11
12
{tobj = new SNList("proximalB") snlist.append(tobj)}
for i=0,3 tobj.add(bild.topol.slist.object(fscan()))
1
2
3
4
{tobj = new SNList("distalB") snlist.append(tobj)}
for i=0,7 tobj.add(bild.topol.slist.object(fscan()))
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6
7
8
9
10
11
12
{consist()}
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(2)
tobj.value = 99
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 3
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 3
bild.subsets.snlist.object(3).geo.append(tobj)
tobj = new GeoSpec(2)
tobj.value = 198
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 1
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 6
bild.subsets.snlist.object(4).geo.append(tobj)
tobj = new GeoSpec(2)
tobj.value = 31
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 31
bild.topol.slist.object(0).geo.append(tobj)
tobj = new GeoSpec(6)
tobj.value = 1
bild.topol.slist.object(0).geo.append(tobj)
set_default()
}
{object_pop()}
{
}
{object_push(memb)}
{first=0}
{
tobj = new FakeMechStan(0)
tobj.value = 150
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new FakeMechStan(1)
tobj.value = 1
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("ahp")
tobj.set("gbar_ahp", 0.002716, 0)
tobj.set("Erev_ahp", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("nap")
tobj.set("gbar_nap", 2.36e-05, 0)
tobj.set("Erev_nap", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("gbar_na", 0.043, 0)
tobj.set("Erev_na", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 3.78e-05, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("lva")
tobj.set("gbar_lva", 0.000166, 0)
tobj.set("Erev_lva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("kslow")
tobj.set("gbar_kslow", 0.000519, 0)
tobj.set("Erev_kslow", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 0.000166, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.002385, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("h")
tobj.set("gbar_h", 6.6e-05, 0)
tobj.set("Erev_h", -46, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 7.46e-05, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("caleak")
tobj.set("g_caleak", 1.66e-06, 0)
tobj.set("Erev_caleak", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("bkfast")
tobj.set("gbar_bkfast", 0.03753, 0)
tobj.set("Erev_bkfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("a")
tobj.set("gbar_a", 0.000755, 0)
tobj.set("Erev_a", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_soma")
tobj.set("B_ca_soma", 0.025, 0)
tobj.set("K2f_ex_ca_soma", 1.32e-12*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_soma", 3.97e-09*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(1).ml.append(tobj)
}
{
tobj = new MechanismStandard("nmda")
tobj.set("gbar_nmda", 0.00257, 0)
tobj.set("Erev_nmda", 0, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(2).ml.append(tobj)
}
{
tobj = new MechanismStandard("nap")
tobj.set("gbar_nap", 3.8e-05, 0)
tobj.set("Erev_nap", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("gbar_na", 0.00288, 0)
tobj.set("Erev_na", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 7e-07, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("lva")
tobj.set("gbar_lva", 0.000651, 0)
tobj.set("Erev_lva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("kslow")
tobj.set("gbar_kslow", 0.000406, 0)
tobj.set("Erev_kslow", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 3.69e-06, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.001417, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("h")
tobj.set("gbar_h", 6.6e-05, 0)
tobj.set("Erev_h", -46, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 1e-06, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("caleak")
tobj.set("g_caleak", 6.5e-08, 0)
tobj.set("Erev_caleak", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("bkfast")
tobj.set("gbar_bkfast", 0.002572, 0)
tobj.set("Erev_bkfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_prox")
tobj.set("B_ca_prox", 0.025, 0)
tobj.set("K2f_ex_ca_prox", 2.14e-12*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_prox", 1.6e-09*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(3).ml.append(tobj)
}
{
tobj = new MechanismStandard("bkfast")
tobj.set("gbar_bkfast", 0.00064, 0)
tobj.set("Erev_bkfast", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("hva")
tobj.set("gbar_hva", 0.00035, 0)
tobj.set("Erev_hva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("lva")
tobj.set("gbar_lva", 5e-05, 0)
tobj.set("Erev_lva", 80, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("clleak")
tobj.set("g_clleak", 1e-06, 0)
tobj.set("Erev_clleak", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("kleak")
tobj.set("g_kleak", 3.68e-06, 0)
tobj.set("Erev_kleak", -82, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("naleak")
tobj.set("g_naleak", 7.1e-07, 0)
tobj.set("Erev_naleak", 50, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{
tobj = new MechanismStandard("ca_dist")
tobj.set("B_ca_dist", 0.025, 0)
tobj.set("K2f_ex_ca_dist", 3.2e-12*2*FARADAY, 0)
tobj.set("K2f_ATPase_ca_dist", 1.55e-10*2*FARADAY, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(4).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
output_index = 0  output_x = 1
}
{object_pop()}
{
cexport()
}
{object_pop()}
{
save_window_=ocbox_.gtopol
save_window_.size(-200,200,-150,150)
scene_vector_[3] = save_window_
ocbox_.gtopol = save_window_
save_window_.save_name("ocbox_.gtopol")
}
{
ocbox_.map("CellBuild[1]", 284, 92, 883.2, 678.72)
}
objref ocbox_
//End CellBuild[1]

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