Readme for the octave code associated with the publication
Toth TI, Crunelli V. Estimation of the activation and
kinetic properties of I(Na) and I(K) from the time course
of the action potential.
J Neurosci Methods. 2001 Oct 30;111(2):111-26.
School of Biosciences, Physiology Unit, Cardiff University,
P.O. Box 911, CF10 3US, Cardiff, UK. email@example.com
A detailed knowledge of the quantitative properties of the
currents I(Na) and I(K) underlying the action potential is
essential for a deeper understanding of neuronal excitatory
processes. However, it is not always possible or practical
to perform voltage-clamp measurements that usually provide
the necessary data. In this paper, we present a method by
which the activation and kinetic properties of these
currents can be estimated from current-clamp data, more
precisely from the time course of the action potential,
provided some additional electrophysiological properties
of the neurone are a priori known. We report results from
thalamocortical neurones and a cortical pyramidal cell,
and suggest that the method will work with other types of
neurones, if their action potentials are primarily shaped
by I(Na) and I(K).
Please see the file users_guide.txt for usage instructions.
These files were supplied by Dr T.I. Toth.