Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
A model for pituitary GH(3) lactotroph (Wu and Chang 2005)
Download zip file
Help downloading and running models
The ATP-sensitive K(+) (K(ATP)) channels are composed of sulfonylurea receptor and inwardly rectifying K(+) channel (Kir6.2) subunit. These channels are regulated by intracellular ADP/ATP ratio and play a role in cellular metabolism. ... The objective of this study was to determine whether Diethyl pyrocarbonate (DEPC) modifies K(ATP)-channel activity in pituitary GH(3) cells. ... Simulation studies also demonstrated that the increased conductance of K(ATP)-channels used to mimic DEPC actions reduced the frequency of spontaneous action potentials and fluctuation of intracellular Ca(2+). The results indicate that chemical modification with DEPC enhances K(ATP)-channel activity and influences functional activities of pituitary GH(3) cells. See paper for more and details.
Wu SN, Chang HD (2006) Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH(3) cells.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
ATP-senstive potassium current;
Ion Channel Kinetics;
Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
for information about:
ATP-senstive potassium current
Download the displayed file
Loading data, please wait...