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Spike frequency adaptation in spinal sensory neurones (Melnick et al 2004)
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Using tight-seal recordings from rat spinal cord slices, intracellular labelling and computer simulation, we analysed the mechanisms of spike frequency adaptation in substantia gelatinosa (SG) neurones. Adapting-firing neurones (AFNs) generated short bursts of spikes during sustained depolarization and were mostly found in lateral SG. ... Ca2 + -dependent conductances do not contribute to adapting firing. Transient KA current was small and completely inactivated at resting potential suggesting that adapting firing was mainly generated by voltage-gated Na+ and delayed-rectifier K+ (KDR ) currents. ... Computer simulation has further revealed that down-regulation of Na+ conductance represents an effective mechanism for the induction of firing adaptation. It is suggested that the cell-specific regulation of Na+ channel expression can be an important factor underlying the diversity of firing patterns in SG neurones. See paper for more and details.
Melnick IV, Santos SF, Safronov BV (2004) Mechanism of spike frequency adaptation in substantia gelatinosa neurones of rat.
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Neuron or other electrically excitable cell;
Short-term Synaptic Plasticity;
Spike Frequency Adaptation;
Safronov, Boris [safronov at ibmc.up.pt];
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