Tonic firing in substantia gelatinosa neurons (Melnick et al 2004)

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Accession:62285
Ionic conductances underlying excitability in tonically firing neurons (TFNs) from substantia gelatinosa (SG) were studied by the patch-clamp method in rat spinal cord slices. ... Suppression of Ca2+ and KCA currents ... did not abolish the basic pattern of tonic firing, indicating that it was generated by voltage-gated Na+ and K+ currents. ... on the basis of present data, we created a model of TFN and showed that Na+ and KDR currents are sufficient to generate a basic pattern of tonic firing. It is concluded that the balanced contribution of all ionic conductances described here is important for generation and modulation of tonic firing in SG neurons. See paper for more and details.
Reference:
1 . Melnick IV, Santos SF, Szokol K, Szûcs P, Safronov BV (2004) Ionic basis of tonic firing in spinal substantia gelatinosa neurons of rat. J Neurophysiol 91:646-55 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns;
Implementer(s): Safronov, Boris [safronov at ibmc.up.pt];
Search NeuronDB for information about:  I Na,t; I A; I K;
xopen("$(NEURONHOME)/lib/hoc/noload.hoc")
pwman_place(20,21)
ndend=1
create soma, hillock, axon, dend[ndend]


access soma
{diam=10 L=10 nseg=10} // area 100 um2 means mA/cm2 identical to nA 
insert B_Na
insert B_A
insert B_DR
insert KDR
insert KDRI
insert pas

access hillock
{L=3 nseg=30 dsoma=1 daxon=0.5 diam(0:1)=dsoma:daxon}
insert B_Na
insert B_A
insert B_DR
insert KDR
insert KDRI
insert pas

access axon
{diam=0.5 L=25 nseg=50}
insert B_Na
insert B_A
insert B_DR
insert KDR
insert KDRI
insert pas

for i=0, ndend-1 dend[i] {
	nseg=50
	diam=4
//	diam(0.43:1) = 4:0  // tapering of the distal dendrite
	L=1000
//insert B_Na
insert SS
insert B_DR
insert KDR
insert KDRI	
insert pas
}

soma connect hillock(0),1
hillock connect axon(0),1
for i=0,ndend-1 soma connect dend[i](0),0 

{
//load_proc("nrnmainmenu")
load_file("electrod.hoc")
//load_template("Electrode")
//load_template("MenuExplore")
//load_template("PointProcessLocator")
//load_template("ShowMechanism")
//load_template("Inserter")
//load_template("PointProcessManager")


//xopen("$(NEURONHOME)/Demo/b/tonic.ses")
xopen("tonic.ses")
forall Ra=80
}

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