Rat subthalamic projection neuron (Gillies and Willshaw 2006)

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Accession:74298
A computational model of the rat subthalamic nucleus projection neuron is constructed using electrophysiological and morphological data and a restricted set of channel specifications. The model cell exhibits a wide range of electrophysiological behaviors characteristic of rat subthalamic neurons. It reveals that a key set of three channels play a primary role in distinguishing behaviors: a high-voltage-activated calcium channel (Cav 1.2.-1.3), a low-voltage-activated calcium channel (Cav 3.-), and a small current calcium-activated potassium channel (KCa 2.1-2.3). See paper for more and details.
Reference:
1 . Gillies A, Willshaw D (2006) Membrane channel interactions underlying rat subthalamic projection neuron rhythmic and bursting activity. J Neurophysiol 95:2352-65 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Subthalamus nucleus projection neuron;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.3 CACNA1D; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.2 CACNA1B; KCa2.2 KCNN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting;
Implementer(s): Gillies, Andrew [andrew at anc.ed.ac.uk];
Search NeuronDB for information about:  I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed; 
Model of the rat subthalamic projection neuron.

This code is associated with the paper:

Gillies, A. and Willshaw, D. (2006)
"Membrane channel interactions underlying rat subthalamic projection
neuron rhythmic and bursting activity"
J. Neurophys. 95, 2352-2365



The main hoc file is called sample.hoc

1. building the modfiles:

for linux/unix run the command
   nrnivmodl

for windows run the command mknrndll

2. To run the sample simulations, execute nrngui with the 
sample.hoc file.

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