Neocortical pyramidal neuron: deep; effects of dopamine (Durstewitz et al 2000)

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Accession:82849
"... Simulated dopamine strongly enhanced high, delay-type activity but not low, spontaneous activity in the model network. Furthermore the strength of an afferent stimulation needed to disrupt delay-type activity increased with the magnitude of the dopamine-induced shifts in network parameters, making the currently active representation much more stable. Stability could be increased by dopamine-induced enhancements of the persistent Na(+) and N-methyl-D-aspartate (NMDA) conductances. Stability also was enhanced by a reduction in AMPA conductances. The increase in GABA(A) conductances that occurs after stimulation of dopaminergic D1 receptors was necessary in this context to prevent uncontrolled, spontaneous switches into high-activity states (i.e., spontaneous activation of task-irrelevant representations). In conclusion, the dopamine-induced changes in the biophysical properties of intrinsic ionic and synaptic conductances conjointly acted to highly increase stability of activated representations in PFC networks and at the same time retain control over network behavior and thus preserve its ability to adequately respond to task-related stimuli. ..." See paper and references for more and details.
Reference:
1 . Durstewitz D, Seamans JK, Sejnowski TJ (2000) Dopamine-mediated stabilization of delay-period activity in a network model of prefrontal cortex. J Neurophysiol 83:1733-50 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Calcium dynamics;
Implementer(s): Durstewitz, Daniel [daniel.durstewitz at plymouth.ac.uk];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I K; I Potassium;
/* 4-compartment model of a deep layer PFC pyramidal cell */
/* from Durstewitz et al. (2000), J.Neurophysiol. 83: 1733-50 */


load_proc("nrnmainmenu")



create 	soma,\
	dend[3]  /*dend[0]=basal, dend[1]=proximal, dend[2]=distal*/

connect dend[0](0), soma(0)
connect dend[1](0), soma(1)
connect dend[2](0), dend[1](1)



soma{
	nseg=1
	L=86.3
	diam=6.14  /* L and diam chosen to match surface area and internal*/
		   /*  resistance with a sphere of diam 23 microns */




	insert Naf
	gnafbar_Naf = 0.086

	insert Nap
	gnapbar_Nap = 0.0022

	insert Hva
	ghvabar_Hva = 0.00034

	insert kdr
	gkdrbar_kdr = 0.0338

	insert IKs
	gKsbar_IKs = 0.00014

	insert iC
	gkcbar_iC = 0.0022

	insert cadyn
	CAF_cadyn=385.948e-9
	tca_cadyn =250
}

dend[0]{
	nseg=1
	L=150.0
	diam=16.0

	insert Naf
	gnafbar_Naf = 0.028

	insert Nap
	gnapbar_Nap = 0.001

	insert Hva
	ghvabar_Hva = 0.0007

	insert kdr
	gkdrbar_kdr = 0.0092

	insert IKs
	gKsbar_IKs = 0.00024

	insert iC
	gkcbar_iC = 0.0038

	insert cadyn
	CAF_cadyn=964.87e-9
	tca_cadyn =120

}

dend[1]{
	nseg=1
	L=400.0
	diam=2.6


	insert Naf
	gnafbar_Naf = 0.028

	insert Nap
	gnapbar_Nap = 0.001

	insert Hva
	ghvabar_Hva = 0.0007

	insert kdr
	gkdrbar_kdr = 0.0092

	insert IKs
	gKsbar_IKs = 0.00024

	insert iC
	gkcbar_iC = 0.0038

	insert cadyn
	CAF_cadyn=964.87e-9
	tca_cadyn =120


}

dend[2]{
	nseg=1
	L=400
	diam=2.6


	insert Naf
	gnafbar_Naf = 0.028

	insert Hva
	ghvabar_Hva = 0.00034

	insert kdr
	gkdrbar_kdr = 0.0092

	insert IKs
	gKsbar_IKs = 0.00024

	insert iC
	gkcbar_iC = 0.0022

	insert cadyn
	CAF_cadyn=964.87e-9
	tca_cadyn =80

}
	

forall{
	insert kdyn
	insert pas
      	cm = 2.3         /* microF/cm2 */
	g_pas = 6.39e-5  /* mho/cm2 */
        e_pas = -70
	Ra = 150         /* ohm-cm */
}


soma {
	g_pas = 3.33e-5
	cm = 1.2

}


cao0_ca_ion = 2  /* mM */
cai0_ca_ion = 50e-6   /* mM */
ko0_k_ion = 3.82  /* mM */
ki0_k_ion = 140   /* mM */
celcius   = 23

tstop=1700

access soma

nrnmainmenu()
nrncontrolmenu()
newPlotV()




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