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A single column thalamocortical network model (Traub et al 2005)
Download zip file
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Model Information
Model File
Citations
Accession:
45539
To better understand population phenomena in thalamocortical neuronal ensembles, we have constructed a preliminary network model with 3,560 multicompartment neurons (containing soma, branching dendrites, and a portion of axon). Types of neurons included superficial pyramids (with regular spiking [RS] and fast rhythmic bursting [FRB] firing behaviors); RS spiny stellates; fast spiking (FS) interneurons, with basket-type and axoaxonic types of connectivity, and located in superficial and deep cortical layers; low threshold spiking (LTS) interneurons, that contacted principal cell dendrites; deep pyramids, that could have RS or intrinsic bursting (IB) firing behaviors, and endowed either with non-tufted apical dendrites or with long tufted apical dendrites; thalamocortical relay (TCR) cells; and nucleus reticularis (nRT) cells. To the extent possible, both electrophysiology and synaptic connectivity were based on published data, although many arbitrary choices were necessary.
References:
1 .
Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FE, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA (2005) Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts.
J Neurophysiol
93
:2194-232
[
PubMed
]
2 .
Traub RD, Contreras D, Whittington MA (2005) Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.
J Clin Neurophysiol
22
:330-42
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Neocortex;
Thalamus;
Cell Type(s):
Thalamus geniculate nucleus/lateral principal GLU cell;
Thalamus reticular nucleus GABA cell;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Neocortex fast spiking (FS) interneuron;
Neocortex spiking regular (RS) neuron;
Neocortex spiking low threshold (LTS) neuron;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I T low threshold;
I A;
I K;
I M;
I h;
I K,Ca;
I Calcium;
I A, slow;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
FORTRAN;
Model Concept(s):
Activity Patterns;
Bursting;
Temporal Pattern Generation;
Oscillations;
Simplified Models;
Epilepsy;
Sleep;
Spindles;
Implementer(s):
Traub, Roger D [rtraub at us.ibm.com];
Search NeuronDB
for information about:
Thalamus geniculate nucleus/lateral principal GLU cell
;
Thalamus reticular nucleus GABA cell
;
Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell
;
Neocortex U1 L6 pyramidal corticalthalamic GLU cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,p
;
I Na,t
;
I L high threshold
;
I T low threshold
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I Calcium
;
I A, slow
;
Files displayed below are from the
ifc fortran
g77
NEURON
neuroConstruct
implementation
/
nrntraub
mod
alphasyndiffeq.mod
*
Other models using alphasyndiffeq.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
alphasynkin.mod
*
Other models using alphasynkin.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
alphasynkint.mod
*
Other models using alphasynkint.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
ampa.mod
*
Other models using ampa.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
ar.mod
*
Other models using ar.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
cad.mod
*
Other models using cad.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
cal.mod
*
Other models using cal.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
cat.mod
*
Other models using cat.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
cat_a.mod
*
Other models using cat_a.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
gabaa.mod
*
Other models using gabaa.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Dendro-dendritic synaptic circuit (Shepherd Brayton 1979)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
iclamp_const.mod
*
Other models using iclamp_const.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
k2.mod
*
Other models using k2.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
ka.mod
*
Other models using ka.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
ka_ib.mod
*
Other models using ka_ib.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kahp.mod
*
Other models using kahp.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kahp_deeppyr.mod
*
Other models using kahp_deeppyr.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kahp_slower.mod
*
Other models using kahp_slower.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kc.mod
*
Other models using kc.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kc_fast.mod
*
Other models using kc_fast.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kdr.mod
*
Other models using kdr.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
kdr_fs.mod
*
Other models using kdr_fs.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
km.mod
*
Other models using km.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
naf.mod
*
Other models using naf.mod:
CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
naf_tcr.mod
*
Other models using naf_tcr.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
naf2.mod
*
Other models using naf2.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
nap.mod
*
Other models using nap.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
napf.mod
*
Other models using napf.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
napf_spinstell.mod
*
Other models using napf_spinstell.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
napf_tcr.mod
*
Other models using napf_tcr.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
par_ggap.mod
*
Other models using par_ggap.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
pulsesyn.mod
*
Other models using pulsesyn.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
rampsyn.mod
*
Other models using rampsyn.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
rand.mod
*
Other models using rand.mod:
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
ri.mod
*
Other models using ri.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
traub_nmda.mod
*
Other models using traub_nmda.mod:
Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
Parametric computation and persistent gamma in a cortical model (Chambers et al. 2012)
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