Recording from rod bipolar axon terminals in situ (Oltedal et al 2007)

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"... Whole cell recordings from axon terminals and cell bodies were used to investigate the passive membrane properties of rod bipolar cells and analyzed with a two-compartment equivalent electrical circuit model developed by Mennerick et al. For both terminal- and soma-end recordings, capacitive current decays were well fitted by biexponential functions. Computer simulations of simplified models of rod bipolar cells demonstrated that estimates of the capacitance of the axon terminal compartment can depend critically on the recording location, with terminal-end recordings giving the best estimates. Computer simulations and whole cell recordings demonstrated that terminal-end recordings can yield more accurate estimates of the peak amplitude and kinetic properties of postsynaptic currents generated at the axon terminals due to increased electrotonic filtering of these currents when recorded at the soma. ..." See paper for more and details.
1 . Oltedal L, Mørkve SH, Veruki ML, Hartveit E (2007) Patch-clamp investigations and compartmental modeling of rod bipolar axon terminals in an in vitro thin-slice preparation of the mammalian retina. J Neurophysiol 97:1171-87 [PubMed]
2 . Mennerick S, Zenisek D, Matthews G (1997) Static and dynamic membrane properties of large-terminal bipolar cells from goldfish retina: experimental test of a compartment model. J Neurophysiol 78:51-62 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina bipolar GLU cell;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Methods;
Implementer(s): Oltedal, Leif [Leif.Oltedal at];
Search NeuronDB for information about:  Retina bipolar GLU cell;
proc init() {local dtsav, temp
	finitialize( v_init)
	t = -1e10
	dtsav = dt
	dt = 1e9
	// if cvode is on, turn it off to do large fixed step
	temp =
	if (temp!=0) {}
	while (t<-1e9) {fadvance() }
	// restore cvode if necessary
	if (temp!=0) {}
	dt = dtsav
	t = 0
	if ( {cvode.re_init()
} 	else {

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