ModelDB: Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)

Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)

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Accession:85112

"The tetrodotoxin-resistant (TTX-r) persistent Na(+) current, attributed to Na(V)1.9, was recorded in small (< 25 mum apparent diameter) dorsal root ganglion (DRG) neurones cultured from P21 rats and from adult wild-type and Na(V)1.8 null mice. ... Numerical simulation of the up-regulation qualitatively reproduced changes in sensory neurone firing properties. ..." Note: models of NaV1.8 and NaV1.9 and also persistent and transient Na channels that collectively model Nav 1.1, 1.6, and 1.7 are present in this model.
Reference:
1 . Baker MD (2005) Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones. J Physiol 567:851-67 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Dorsal Root Ganglion (DRG) cell;
Channel(s):	I Na,p; I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):	Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Nav1.9 SCN11A SCN12A;
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Ion Channel Kinetics; Action Potentials; Signaling pathways; Nociception;
Implementer(s):	Morse, Tom [Tom.Morse at Yale.edu];