Model of calcium oscillations in olfactory cilia (Reidl et al. 2006)

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Accession:86538
Simulation of experiments on olfactory receptor neurons (ORNs). Focussing on the negative feedback that calcium (through calmodulin) has on its own influx through CNG channels, this model is able to reproduce both calcium oscillations as well as adaptation behaviour as seen in experiments done with ORNs.
References:
1 . Reidl J, Borowski P, Sensse A, Starke J, Zapotocky M, Eiswirth M (2006) Model of calcium oscillations due to negative feedback in olfactory cilia. Biophys J 90:1147-55 [PubMed]
2 . Borowski P (2006) Stochastic dynamics in olfactory signal transduction and development, Dissertation http://nbn-resolving.de/urn:nbn:de:swb:14-1159519135136-2269
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Olfactory receptor GLU cell;
Channel(s): I CNG;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Olfaction;
Implementer(s):
Search NeuronDB for information about:  Olfactory receptor GLU cell; I CNG;
 
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Ca_dyn_ORN_Reidl_etal
                            
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