Oscillating neurons in the cochlear nucleus (Bahmer Langner 2006a, b, and 2007)

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Accession:87454
"Based on the physiological and anatomical data, we propose a model consisting of a minimum network of two choppers that are interconnected with a synaptic delay of 0.4 ms (Bahmer and Langner 2006a) . Such minimum delays have been found in different systems and in various animals (e.g. Hackett, Jackson, and Rubel 1982; Borst, Helmchen, and Sakmann 1995). The choppers receive input from both the auditory nerve and an onset neuron. This model can reproduce the mean, standard deviation, and coefficient of variation of the ISI and the dynamic features of AM coding of choppers."
References:
1 . Bahmer A, Langner G (2006) Oscillating neurons in the cochlear nucleus: II. Simulation results. Biol Cybern 95:381-92 [PubMed]
2 . Bahmer A, Langner G (2006) Oscillating neurons in the cochlear nucleus: I. Experimental basis of a simulation paradigm. Biol Cybern 95:371-9 [PubMed]
3 . Bahmer A, Langner G (2007) Simulation of oscillating neurons in the cochlear nucleus: a possible role for neural nets, onset cells, and synaptic delays Hearing - from basic research to applications (Proc. of International Symp. of Hearing), Kollmeier B, Klump G, Hohmann V, Langemann U, Mauermann M, Uppenkamp S, Verhey J, ed.
4 . Bahmer A, Langner G (2009) A simulation of chopper neurons in the cochlear nucleus with wideband input from onset neurons. Biol Cybern 100:21-33 [PubMed]
5 . Bahmer A, Langner G (2010) Parameters for a model of an oscillating neuronal network in the cochlear nucleus defined by genetic algorithms. Biol Cybern 102:81-93 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Cochlear ganglion cell Type II; CN stellate cell; Ventral cochlear nucleus T stellate (chopper) neuron; Abstract integrate-and-fire leaky neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Audition;
Implementer(s): Bahmer, Andreas [Andreas.Bahmer at kgu.de];
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[8]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin NetReadyCellGUI[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new NetReadyCellGUI(1)}
{ocbox_.tobj = new CellBuild(1)}
{object_push(ocbox_.tobj)}
{
version(5.7)
continuous = 0
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "dend"
objref tobj
}
{
tobj = new CellBuildSection("soma",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(0,0,15,0) tobj.lx=7.69231 tobj.ly=-28.637 tobj.i3d=0
all_init()
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{ tobj = snlist.object(0)}
{consist()}
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(2)
tobj.value = 19.5441
bild.subsets.snlist.object(0).geo.append(tobj)
tobj = new GeoSpec(3)
tobj.value = 19.5441
bild.subsets.snlist.object(0).geo.append(tobj)
set_default()
}
{object_pop()}
{
}
{object_push(memb)}
{first=0}
{
tobj = new FakeMechStan(1)
tobj.value = 0.9
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new FakeMechStan(0)
tobj.value = 150
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("kht")
tobj.set("ek_kht", -70, 0)
tobj.set("gkhtbar_kht", 0.0125, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("na")
tobj.set("ena_na", 55, 0)
tobj.set("gnabar_na", 0.0833333, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("leak")
tobj.set("g_leak", 0.000166667, 0)
tobj.set("erev_leak", -65, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("ih")
tobj.set("ghbar_ih", 4.16667e-05, 0)
tobj.set("eh_ih", -43, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
output_index = 0  output_x = 1
}
{object_pop()}
{
cexport()
}
{object_pop()}
{
save_window_=ocbox_.tobj.gtopol
save_window_.size(-200,200,-150,150)
scene_vector_[3] = save_window_
ocbox_.tobj.gtopol = save_window_
save_window_.save_name("ocbox_.tobj.gtopol")
}
{object_push(ocbox_)}
stgui = new SynTypeGUI(1)
{object_push(stgui)}
{
tobj = new MechanismStandard("ExpSyn")
tobj.set("tau", 0.1, 0)
tobj.set("e", 10, 0)
}
{append(tobj, "E")}
{object_pop()}
nrc = new NetReadyCell(tobj, stgui.stypelist)
nrc.name = "Ro"
tobj = nrc.cb.topol.slist.object(0)
{nrc.synlist.append(new SynTypeInstance(nrc.stype.object[0],tobj,0.5,0.5,-1))}
{g.size(-190.529,190.529,-183.252,183.252)}
{object_pop()}
{
ocbox_.map("NetReadyCellGUI[0]", 0, 1155, 425.7, 481.5)
}
objref ocbox_
//End NetReadyCellGUI[0]


//Begin NetGUI[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new NetGUI(1)}
{object_push(ocbox_)}
{mapold2new = new Vector()  missing = new List()}
original_type("Ro")
newnode(0, -97, -5)
newnode(0, 62, -1)
newedge(0, 1, 0, 0.03, 1)
newedge(1, 0, 0, 0.03, 1)
{create_ = 1  create1()}
{g.size(-192.525,192.525,-218.098,218.098)}
{set_alias(0)}
{object_pop()}
{
ocbox_.map("NetGUI[0]", 580, 774, 315.9, 288.9)
}
objref ocbox_
//End NetGUI[0]


//Begin PointProcessGroupManager
{
load_file("pointgrp.hoc")
}
{
ocbox_ = new PointProcessGroupManager(0)
}
{object_push(ocbox_)}
{
ms = new MechanismStandard("IClamp")
ms.set("del", 5, 0)
ms.set("dur", 100, 0)
ms.set("amp", 0.12, 0)
mnews("IClamp", ms)
select(0)
execute("Ro_Cell[0].soma ocbox_.move(0.5)")
ms = new MechanismStandard("IClamp")
ms.set("del", 10, 0)
ms.set("dur", 100, 0)
ms.set("amp", 0.12, 0)
mnews("IClamp", ms)
select(1)
execute("Ro_Cell[1].soma ocbox_.move(0)")
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessGroupManager", 8, 723, 412.2, 313.2)
}
objref ocbox_
//End PointProcessGroupManager


//Begin SpikePlot[0] for NetData[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new SpikePlot(NetData[0],1)}
{object_push(ocbox_)}
mode = 1
fwindow = 100
binwidth = 0.1
build()
{g.size(0,150,0,3)}
{object_pop()}
{
ocbox_.map("SpikePlot[0] for NetData[0]", 1034, 766, 264.6, 294.3)
}
objref ocbox_
//End SpikePlot[0] for NetData[0]

{
save_window_ = new Graph(0)
save_window_.size(0,150,-80,40)
scene_vector_[5] = save_window_
{save_window_.view(0, -80, 150, 120, 750, 111, 558.9, 405.1)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addvar("Ro_Cell[0].soma.v( 0.5 )", 1, 1, 0.8, 0.9, 2)
save_window_.addexpr("Ro_Cell[1].soma.v( 0.5 )", 2, 1, 0.8, 0.9, 2)
}
{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 150
xvalue("t","t", 2 )
tstop = 150
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
screen_update_invl = 0.05
xvalue("Scrn update invl","screen_update_invl", 1,"", 0, 1 )
realtime = 0.2
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(30,19)
}
{
xpanel("Temperature", 0)
celsius = 33
xvalue("celsius","celsius", 1,"", 0, 1 )
xpanel(400,-5)
}
objectvar scene_vector_[1]
{doNotify()}

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