Endothelin action on pituitary latotrophs (Bertram et al. 2006)

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Endothelin (ET-1, -2, and -3 designate three genes which produce different endothelin isopeptides) is a prolactin inhibiting substance of hypothalmic origin. ET-1 binding is part of at least four G protein signaling pathways in lactotrophs. The sequence of events in these pathways following the presentation of nano- and pico-molar concentrations of ET-1 is modeled in the paper.
1 . Bertram R, Tabak J, Toporikova N, Freeman ME (2006) Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Sci STKE 2006:pe4 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Pituitary cell;
Channel(s): I K; I_SERCA;
Gap Junctions:
Transmitter(s): Amino Acids;
Simulation Environment: XPP (web link to model);
Model Concept(s): Activity Patterns; Signaling pathways;
Search NeuronDB for information about:  I K; I_SERCA; Amino Acids;
(located via links below)
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