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Rod photoreceptor (Barnes and Hille 1989, Publio et al. 2006, Kourennyi and Liu et al. 2004)

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Accession:95870
This a conductance-based model of a rod photoreceptor cell based on other modeling works (Barnes and Hille 1989 and Publio et al. 2006 and Kourennyi and Liu et al. 2004 ). In this model four types of ionic channels identified in the inner segment of the rod: nonselective cation channel (h), delayed rectifying potassium channel (Kv), noninactivating potassium channel (Kx) and calcium channel (Ca) was used. The model accurately reproduces the rod response when stimulated with a simulated photocurrent signal. We can show the effect of nonselective cation channel. The absence of this channel cause increasing the peak amplitude and the time to reach the peak of voltage response and absence of transient mode in this response.
References:
1 . Barnes S, Hille B (1989) Ionic channels of the inner segment of tiger salamander cone photoreceptors. J Gen Physiol 94:719-43 [PubMed]
2 . Kourennyi DE, Liu XD, Hart J, Mahmud F, Baldridge WH, Barnes S (2004) Reciprocal modulation of calcium dynamics at rod and cone photoreceptor synapses by nitric oxide. J Neurophysiol 92:477-83 [PubMed]
3 . Liu XD, Kourennyi DE (2004) Effects of tetraethylammonium on Kx channels and simulated light response in rod photoreceptors. Ann Biomed Eng 32:1428-42 [PubMed]
4 . Publio R, Oliveira RF, Roque AC (2006) A realistic model of rod photoreceptor for use in a retina network model Neurocomputing 69:1020-1024
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina photoreceptor cone GLU cell;
Channel(s): I Cl,Ca; I K,Ca; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Calcium dynamics;
Implementer(s): Shahali, Mahboubeh [shahali222 at yahoo.com];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell; I Cl,Ca; I K,Ca; I Calcium; I Potassium; 
: Rod  Photoreceptor Leakage

NEURON 
{
	SUFFIX Leak
	

	
	NONSPECIFIC_CURRENT il
	
	
          
	RANGE glbar, el
	
	

	

}

UNITS
{
	(mA) = (milliamp)
	(mV) = (millivolt)
	(mS) = (millimho)
        
}	

PARAMETER
{
       
       
       : leak
        glbar=0.6 (mS/cm2)
       
	: for 100uM^2 area, =1nS/1GOhm
	 el=-55 (mV)

}


ASSIGNED
{
	v (mV)
	gl (mho/cm2)
	il  (mA/cm2)
          
}





BREAKPOINT
{
        gl= 1e-3*glbar :gl is 3 orders different from glbar

	il  = gl*(v-el)

	: the current is in the unit of mA/cm2
	
}

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