Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)

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Accession:97263
This model shows how backpropagating action potentials in the long lateral dendrites of mitral cells, together with granule cell actions on mitral cells within narrow columns forming glomerular units, can provide a mechanism to activate strong local inhibition between arbitrarily distant mitral cells. The simulations predict a new role for the dendrodendritic synapses in the multicolumnar organization of the granule cells.
Reference:
1 . Migliore M, Shepherd GM (2008) Dendritic action potentials connect distributed dendrodendritic microcircuits. J Comput Neurosci 24:207-21 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Pattern Recognition; Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Action Potentials; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; NMDA; I Na,t; I A; I K; Gaba; Glutamate;
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MT-GC
readme.txt *
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanetOB.mod *
coeff-table.txt *
forfig3.hoc *
gc.hoc *
mitral.hoc *
mosinit.hoc *
                            
begintemplate GC

public somagc, dend, synmt, priden, sampa, priden2

create somagc, priden2[3], dend[6], priden

objref synmt[3], sampa[3]

proc init() {

topol()
geometry()
segments()
memb()

}


proc topol() {local i
	connect priden(0), somagc(1)
	connect priden2[0](0), priden(.6)
	connect priden2[1](0), priden(.8)
	connect priden2[2](0), priden(.9)
	connect dend[0](0), dend[1](1)
	connect dend[1](0), priden2[0](0.5)
	connect dend[2](0), dend[3](1)
	connect dend[3](0), priden2[0](0.6)
	connect dend[4](0), dend[5](1)
	connect dend[5](0), priden2[0](0.4)
}

proc segments() {local i
	somagc.nseg= 1
	forsec "priden" nseg = 10
	forsec "dend" nseg = 1
}

proc geometry() {local i
	somagc { L = 8  diam = 8}
	dend[0] { L=1  diam=1}
	dend[2] { L=1  diam=1}
	dend[4] { L=1  diam=1}
	dend[1] { L=2  diam=.2}
	dend[3] { L=2  diam=.2}
	dend[5] { L=2  diam=.2}
	priden {L=150 diam=.5}
	for i=0, 2 {priden2[i] {L=100 diam=.4}}
	define_shape()
}
	


proc memb() {
	forall {
		insert pas 
		insert kamt gbar_kamt=0.008 ek=-90
		insert nax gbar_nax=0.02 sh_nax=15 ena=60
		Ra = 80
		cm = 1
		g_pas = 1/30000
		e_pas = -65
		ek = -90
	}

	forsec "soma" {
		gbar_nax=0.04
       		insert kdrmt gbar_kdrmt=0.006
		gbar_kamt = 0.004
		cm = 4
		g_pas = cm/30000
	}

	forsec "pri" {
		cm = 4
		g_pas = cm/30000
	}

dend[0] {
	synmt[0] = new nmdanet(1) 
	sampa[0] = new ExpSyn(1)
	sampa[0].e=0
	sampa[0].tau=3
	}

dend[2] {
	synmt[1] = new nmdanet(1) 
	sampa[1] = new ExpSyn(1)
	sampa[1].e=0
	sampa[1].tau=3
	}

dend[4] {
	synmt[2] = new nmdanet(1) 
	sampa[2] = new ExpSyn(1)
	sampa[2].e=0
	sampa[2].tau=3
	}
}

endtemplate GC

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