Rejuvenation model of dopamine neuron (Chan et al. 2007)

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Accession:97860
Model files for the paper C. Savio Chan, et al. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease, Nature 447, 1081-1086(28 June 2007).
Reference:
1 . Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ (2007) 'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature 447:1081-6 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Cav1.3 CACNA1D;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Action Potentials; Parkinson's;
Implementer(s): Held, Joshua [j-held at northwestern.edu];
Search NeuronDB for information about:  I Na,t; I K; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
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rejuvenation
mod
readme.html
build.hoc
graph.hoc
init.hoc
mosinit.hoc
panels.hoc
S5a.jpg
                            
create soma
access soma

v_init = -68
tstop = 10000
celsius = 35
forall Ra = 70

soma {
    L = 15
    diam = 15
    insert nahh
    	gbar_nahh = 0.01
    insert kv1_gp
    	gbar_kv1_gp = 0
    insert kv2_hh
    	gbar_kv2_hh = 0
    insert kv2_simplehh
    	gbar_kv2_simplehh = 0.00015
    insert kv4hh
    	gbar_kv4hh = 0
    insert kcnq_hh
    	gbar_kcnq_hh = 7e-07
    insert kir2_dop
    	gbar_kir2_dop = 0
	insert sk_dop
		gbar_sk_dop = 5e-06
	insert hcn_siegelbaum
		gbar_hcn_siegelbaum = 7e-05
		ehcn_hcn_siegelbaum = -10
	insert cal_dop
		gbar_cal_dop = 5e-05
	insert cap_dop
		gbar_cap_dop = 2.5e-05
    insert leak_dop
    	gbar_leak_dop = 5e-06
    	e_leak_dop = -45
    insert CaDiffuse3
}

ek = -90

cvode.active(0)

cai_init = 5e-05	// (mM)

proc init() {
	finitialize(v_init)
	soma.cai = cai_init
}

Pmax_CaDiffuse3 = 125
TotalBuffer_CaDiffuse3 = 0.0003

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