Fronto-parietal visuospatial WM model with HH cells (Edin et al 2007)

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Accession:98017
1) J Cogn Neurosci: 3 structural mechanisms that had been hypothesized to underlie vsWM development during childhood were evaluated by simulating the model and comparing results to fMRI. It was concluded that inter-regional synaptic connection strength cause vsWM development. 2) J Integr Neurosci: Given the importance of fronto-parietal connections, we tested whether connection asymmetry affected resistance to distraction. We drew the conclusion that stronger frontal connections are beneficial. By comparing model results to EEG, we concluded that the brain indeed has stronger frontal-to-parietal connections than vice versa.
References:
1 . Edin F, Macoveanu J, Olesen P, Tegnér J, Klingberg T (2007) Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci 19:750-60 [PubMed]
2 . Edin F, Klingberg T, Stödberg T, Tegnér J (2007) Fronto-parietal connection asymmetry regulates working memory distractibility. J Integr Neurosci 6:567-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Abstract Wang-Buzsaki neuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Working memory; Attractor Neural Network;
Implementer(s):
Search NeuronDB for information about:  Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; 
# An example of a parameter file for the multimodule network.
# The file name must contain the word SERIES. This file is read by the 
# simulation program MultiModuleWMNet.hoc and by SimLoop, which
# updates the position in this file (Current row). Commented rows
# (beginning with #) are not counted.
#
# The parameters are organized as follows:
# A first row with general parameters and parameters concerning the nets 
#   themselves
# A second row with cues. Cues have five parameters so this row is
#   5 * no of cues long. 
# A third row with experimental parameters of various length
# The rest of the rows specify connections between modules, one connection per
#   row. External cells belong to module 0, so specify from as 0 for external
#   stimulation.
#
# Parameters:
#
# First row:
# type : Type of the net (used by analysis programs for backward compatibility)
#        Should always be 2 for this type of network
# nmod : Number of modules
# nrow : The number of rows that this simulation spans
# t    : The length of the simulation in ms
# dt   : The time step in ms
# Ecell: The type of excitatory cell (1 is the only choice right now)
# NI   : No of I-cells
# NE   : No of E-cells
# One can specify several Ecell-NI-NE triplets after one another, one for
# each module in the network
#
# Second row:
# CueT   : Time of cue
# CuePos : Length of cue.
# CuePos : Position of cue as a cell index (cells are placed in an array with
#          I-cells of first module followed by E-cells of first module 
#          followed by cells in further modules.
# CueW   : Width of cue in cells.
# CueAmp : Amplitude of the cue in uA per cm2
#
# Remaining rows:
# to      : Connection to module
# from    : Connection from module
# deldist : The delay distribution 0 = no distribution, 
#                                  1 = one-point distribution
#                                  2 = Erlang (gamma) distribution
# mu      : Mean of delay distribution in ms
# s2      : Variance of delay distribution in (ms)^2 
# I->E    : Position of gaba synapses onto E-cell, 
#           0 = soma, 1 = proximal dendrite, 2 = distal dendrite
# E->E    : The same for E-cells. Combinations of 0, 1 and 2 can be specified,
#         : but number must not begin with 0.
# relNMDA : The relative amount of excitatory (NMDA+AMPA) current passing 
#           through NMDA channels.
# Ii      : Synaptic weight from I-cells to I-cells in mS per cm2
# Ie      : Synaptic weight from E-cells to I-cells in mS per cm2
# Ei      : Synaptic weight from I-cells to E-cells in mS per cm2
# Ee      : Synaptic weight from E-cells to E-cells in mS per cm2
# Jpii    : Height of connection curve (a gaussian on top of a box) connecting
#           I-cells to I-cells
# stdii   : Standard deviation of that connection curve in radians.
# Jpie    : As above for connection from I-cells to E-cells
# stdie   : Standard deviation of that connection curve in radians.
# Jpei    : As above for connection from E-cells to I-cells
# stdei   : Standard deviation of that connection curve in radians.
# Jpee    : As above for connection from E-cells to E-cells
# stdee   : Standard deviation of that connection curve in radians.
Current row:
00000
####
# 1# 30% NMDA 15ms delay 0% asymmetry
####################################################################################################
#type	nmod	nrow	t0	t	dt	Icell-1	Ecell-1	NI-1	NE-1	Icell-2	Ecell-2	NI-2	NE-2	Save
3	2	13	100	200	0.02	1	1	32	128	1	1	32	128
#Qtim1	Qlen1	Qpos1	Qwid1	Qamp1	Qtim2	Qlen2	Qpos2	Qwid2	Qamp2
1000	500	55	19	1	1000	500	215	19	1
#EXP
-1
#modul-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
1	1	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
1	1	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
1	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	2	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
2	2	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
2	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	1	1	15	0	0	21	1	0	0	0	0.039	-1	-1	-1	-1	-1	-1	3.2	0.2
2	1	1	15	0	0	21	0	0	0	0	0.097	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	1	0	0	0	0.039	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	0	0	0	0	0.097	-1	-1	-1	-1	-1	-1	3.2	0.2
####
# 2#  30% NMDA 15ms delay 100% asymmetry
####################################################################################################
#type	nmod	nrow	t0	t	dt	Icell-1	Ecell-1	NI-1	NE-1	Icell-2	Ecell-2	NI-2	NE-2	Save
3	2	11	100	200	0.02	1	1	32	128	1	1	32	128
#Qtim1	Qlen1	Qpos1	Qwid1	Qamp1	Qtim2	Qlen2	Qpos2	Qwid2	Qamp2
1000	500	55	19	1	1000	500	215	19	1
#EXP
-1
#modul-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
1	1	0	0	0	0	21	1	0.65	0.294	1.16	0.393	-1	-1	-1	-1	-1	-1	3.2	0.2
1	1	0	0	0	0	21	0	0	0.726	0	0.970	-1	-1	-1	-1	-1	-1	3.2	0.2
1	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	2	0	0	0	0	21	1	0.65	0.294	1.16	0.315	-1	-1	-1	-1	-1	-1	3.2	0.2
2	2	0	0	0	0	21	0	0	0.726	0	0.776	-1	-1	-1	-1	-1	-1	3.2	0.2
2	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	1	1	15	0	0	21	1	0	0	0	0.078	-1	-1	-1	-1	-1	-1	3.2	0.2
2	1	1	15	0	0	21	0	0	0	0	0.194	-1	-1	-1	-1	-1	-1	3.2	0.2
####
# 3# 30% NMDA 15ms delay 25% asymmetry
####################################################################################################
#type	nmod	nrow	t0	t	dt	Icell-1	Ecell-1	NI-1	NE-1	Icell-2	Ecell-2	NI-2	NE-2	Save
3	2	13	100	200	0.02	1	1	32	128	1	1	32	128
#Qtim1	Qlen1	Qpos1	Qwid1	Qamp1	Qtim2	Qlen2	Qpos2	Qwid2	Qamp2
1000	500	55	19	1	1000	500	215	19	1
#EXP
-1
#modul-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
1	1	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
1	1	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
1	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	2	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
2	2	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
2	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	1	1	15	0	0	21	1	0	0	0	0.049	-1	-1	-1	-1	-1	-1	3.2	0.2
2	1	1	15	0	0	21	0	0	0	0	0.121	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	1	0	0	0	0.029	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	0	0	0	0	0.073	-1	-1	-1	-1	-1	-1	3.2	0.2
####
# 4# 30% NMDA 15ms delay 50% asymmetry
####################################################################################################
#type	nmod	nrow	t0	t	dt	Icell-1	Ecell-1	NI-1	NE-1	Icell-2	Ecell-2	NI-2	NE-2	Save
3	2	13	100	200	0.02	1	1	32	128	1	1	32	128
#Qtim1	Qlen1	Qpos1	Qwid1	Qamp1	Qtim2	Qlen2	Qpos2	Qwid2	Qamp2
1000	500	55	19	1	1000	500	215	19	1
#EXP
-1
#modul-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
1	1	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
1	1	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
1	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	2	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
2	2	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
2	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	1	1	15	0	0	21	1	0	0	0	0.059	-1	-1	-1	-1	-1	-1	3.2	0.2
2	1	1	15	0	0	21	0	0	0	0	0.146	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	1	0	0	0	0.019	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	0	0	0	0	0.048	-1	-1	-1	-1	-1	-1	3.2	0.2
####
# 5# 30% NMDA 15ms delay 75% asymmetry
####################################################################################################
#type	nmod	nrow	t0	t	dt	Icell-1	Ecell-1	NI-1	NE-1	Icell-2	Ecell-2	NI-2	NE-2	Save
3	2	13	100	200	0.02	1	1	32	128	1	1	32	128
#Qtim1	Qlen1	Qpos1	Qwid1	Qamp1	Qtim2	Qlen2	Qpos2	Qwid2	Qamp2
1000	500	55	19	1	1000	500	215	19	1
#EXP
-1
#modul-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
1	1	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
1	1	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
1	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	2	0	0	0	0	21	1	0.65	0.294	1.16	0.354	-1	-1	-1	-1	-1	-1	3.2	0.2
2	2	0	0	0	0	21	0	0	0.726	0	0.873	-1	-1	-1	-1	-1	-1	3.2	0.2
2	0	0	0	0	0	2	0	0	0.0024	0	0.011	-1	-1	-1	-1	-1	-1	-1	-1
#modul-2-1
#to	from	deldist	mu	s2	I->E	E->E	relNMDA	Ii	Ie	Ei	Ee	Jpii	stdii	Jpie	stdie	Jpei	stdei	Jpee	stdee
2	1	1	15	0	0	21	1	0	0	0	0.068	-1	-1	-1	-1	-1	-1	3.2	0.2
2	1	1	15	0	0	21	0	0	0	0	0.170	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	1	0	0	0	0.010	-1	-1	-1	-1	-1	-1	3.2	0.2
1	2	1	15	0	0	21	0	0	0	0	0.024	-1	-1	-1	-1	-1	-1	3.2	0.2

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