Fronto-parietal visuospatial WM model with HH cells (Edin et al 2007)

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Accession:98017
1) J Cogn Neurosci: 3 structural mechanisms that had been hypothesized to underlie vsWM development during childhood were evaluated by simulating the model and comparing results to fMRI. It was concluded that inter-regional synaptic connection strength cause vsWM development. 2) J Integr Neurosci: Given the importance of fronto-parietal connections, we tested whether connection asymmetry affected resistance to distraction. We drew the conclusion that stronger frontal connections are beneficial. By comparing model results to EEG, we concluded that the brain indeed has stronger frontal-to-parietal connections than vice versa.
References:
1 . Edin F, Macoveanu J, Olesen P, Tegnér J, Klingberg T (2007) Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci 19:750-60 [PubMed]
2 . Edin F, Klingberg T, Stödberg T, Tegnér J (2007) Fronto-parietal connection asymmetry regulates working memory distractibility. J Integr Neurosci 6:567-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Abstract Wang-Buzsaki neuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Working memory; Attractor Neural Network;
Implementer(s):
Search NeuronDB for information about:  Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
% This script plots arrows between the populations in showConnMulti.m

% x_po, y_po: Coordinates of the post-population
% x_pr, y_pr: Coordinates of the pre-population
% an           : Angle of inclination
% x0, y0 : Coordinates of arrow shaft
% x1, y1 : Coordinates of arrow point
% x2, y2 : Coordinates of arrowhead right corner
% x3, y3 : Coordinates of arrowhead left corner

% For auto-arrow
% x4, y4, x5, y5, x6, y6, etc: Other arrow points

%Arrowhead
w2 = pi/6;
r2 = 0.05;
w3 = -pi/6;
r3 = 0.05;

for iiiii = 1:length( arrows )
    x_po = pop( arrows(iiiii).post ).x;  
    y_po = pop( arrows(iiiii).post ).y;
  
    if arrows(iiiii).pre == arrows(iiiii).post % self connection
        d = 0.025;
        an = abs( arrows(iiiii).labpos );
        r = pop( arrows(iiiii).post ).radius;
        [x1,y1] = pol2cart(an, r );
        x7 = x_po + x1 * sqrt( r*r-d*d ) / r;
        y7 = y_po + y1 * sqrt( r*r-d*d ) / r;
        x6 = x7 + 0.1*cos(an);
        y6 = y7 + 0.1*sin(an);
        x1 = x7 + d * cos(an+pi/2);
        y1 = y7 + d * sin(an+pi/2);
        x0 = x1 + 0.1*cos(an);
        y0 = y1 + 0.1*sin(an);
        x4 = x7 - d * cos(an+pi/2);
        y4 = y7 - d * sin(an+pi/2);
        x5 = x4 + 0.1*cos(an);
        y5 = y4 + 0.1*sin(an);
    
       line( [x0 x5], [y0 y5] )
       line( [x4 x5], [y4 y5] )
    
   elseif arrows(iiiii).pre < 0  % external connection
       an = abs( arrows(iiiii).pre );
       x_pr = x_po + 0.1*cos( an );
       y_pr = y_po + 0.1*sin( an );
       [x1,y1] = pol2cart(an, pop( arrows(iiiii).post ).radius );
       x1 = x1 + x_po;
       y1 = y1 + y_po;
       x0 = x1 + 0.1*cos(an);
       y0 = y1 + 0.1*sin(an);
       
       
       
   else  % arrow between populations
       x_pr = pop( arrows(iiiii).pre).x;
       y_pr = pop( arrows(iiiii).pre).y;
       if x_pr == x_po
           an = pi/2+pi*(y_po>y_pr);
       else
           an = atan( (y_pr-y_po)/(x_pr-x_po) );
       end
       if x_pr<x_po
           an = an+pi;
       end
       [x0,y0] = pol2cart(an+pi, pop( arrows(iiiii).pre ).radius );
       x0 = x0 + x_pr;
       y0 = y0 + y_pr;
       [x1,y1] = pol2cart(an, pop( arrows(iiiii).post ).radius );
       x1 = x1 + x_po;
       y1 = y1 + y_po;
   end 
   
    
   
   [x2,y2] = pol2cart(w2+an,r2);
   x2 = x2 + x1;  
   y2 = y2 + y1;
   [x3,y3] = pol2cart(w3+an,r3);
   x3 = x3 + x1;  
   y3 = y3 + y1;
  
   line( [x1 x2], [y1 y2] )
   line( [x1 x3], [y1 y3] )
   line( [x0 x1], [y0 y1] )
    

  
  
   % Plot labels
   txxt(iiiii) =text( 0, 0, arrows(iiiii).label );
   pos = get( txxt(iiiii), 'Extent' );
   wt = pos(3);
   ht = pos(4);
   delete( txxt(iiiii) )
  
      
           
   % d = 1 on right side of arrow, d = -1 on left side of arrow (seen in the
   % direction of the arrow
   d = 2 * arrows(iiiii).labpos - 1;
   
   % kant = 0,1,2,3 when right,upper,left and lower border of text box is next to arrow 
   kant = mod( floor( an/(pi/2) ) + 1 + arrows(iiiii).labpos, 4 );
  
   % dlr = 1 towards left, -1 towards right, dud = 1 upward, -1 downward
   dlr = ( 2 * ( mod( an, 2*pi ) < pi ) - 1 ) * d;
   dud = ( 2 * ( mod( an+pi/2, 2*pi ) < pi ) - 1 ) * d;
   if arrows(iiiii).pre == arrows(iiiii).post % self connection
       xxx(iiiii) = x6;
       yyy(iiiii) = y6; 
       dlr = ( 2 * ( mod( an-pi/2, 2*pi ) < pi ) - 1 );
       dud = ( 2 * ( mod( an, 2*pi ) < pi ) - 1 );
   else
       if d == 1
           xxx(iiiii) = x2;
           yyy(iiiii) = y2;
       else
           xxx(iiiii) = x3;
           yyy(iiiii) = y3;
       end
       if an == 3*pi/2 | an == pi/2 % to get right sign on tan
           an = 3*pi/2+0.000001;
       end
       if mod( kant, 2 )
           if abs( tan(an) ) < 10000
               yyy(iiiii) = y1 + (xxx(iiiii)-x1)*(tan(an));
           else
               yyy(iiiii) = y1 + (xxx(iiiii)-x1)*sign( tan( an ) ) * 10000;
           end
       else
           if abs( tan(an) ) > 1/10000
               xxx(iiiii) = x1 + (yyy(iiiii)-y1)/(tan(an));
           else
               xxx(iiiii) = x1 + (yyy(iiiii)-y1)*1e10;
           end
       end
       if mod( kant+d, 4 ) == 0
           if yyy(iiiii) > y2+ht
               yyy(iiiii) = y2;
               dud = dud*(-1);
           end
       elseif mod( kant+d, 4 ) == 1
           if xxx(iiiii) < x2-wt
               xxx(iiiii) = x2;
               dlr = dlr * (-1);
           end
       elseif mod( kant+d, 4 ) == 2
           if yyy(iiiii) < y2-ht
               yyy(iiiii) = y2;
               dud = dud * (-1);
           end
       elseif mod( kant+d, 4 ) == 3
           if xxx(iiiii) > x2+wt
               xxx(iiiii) = x2;
               dlr = dlr * (-1);
           end
       end
   end
   if dlr > 0
       hstr = 'right';
   else
       hstr = 'left';
   end
   if dud > 0 
       vstr = 'bottom';
   else 
       vstr = 'top';
   end
end

arrrr = arrows;
i = 1;
while length(xxx)>0
    curr = find(xxx == xxx(1) & yyy == yyy(1));
    currlab = [arrrr(curr(1)).label];
    for i = 2:length(curr)
        currlab = [currlab ', ' arrrr(curr(i)).label];
    end
    txxt(i) = text( xxx(1), yyy(1), currlab, ...
 		      'HorizontalAlignment', hstr, 'VerticalAlignment', vstr );
    xxx(curr) = [];
    yyy(curr) = [];
    arrrr(curr) = [];
    i = i + 1;
end
set( gca, 'FontSize', 14 )

   

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