Citation Relationships



Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002[PubMed]

   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009)

References and models cited by this paper

References and models that cite this paper

Bi GQ, Poo MM (1998) Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci 18:10464-72 [PubMed]

Boiko T, Rasband MN, Levinson SR, Caldwell JH, Mandel G, Trimmer JS, Matthews G (2001) Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron 30:91-104 [PubMed]

Boiko T, Van Wart A, Caldwell JH, Levinson SR, Trimmer JS, Matthews G (2003) Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J Neurosci 23:2306-13 [PubMed]

Clark BA, Monsivais P, Branco T, London M, Hausser M (2005) The site of action potential initiation in cerebellar Purkinje neurons. Nat Neurosci 8:137-9 [PubMed]

Colbert CM, Johnston D (1996) Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. J Neurosci 16:6676-86 [PubMed]

Colbert CM, Johnston D (1998) Protein kinase C activation decreases activity-dependent attenuation of dendritic Na+ current in hippocampal CA1 pyramidal neurons. J Neurophysiol 79:491-5 [Journal] [PubMed]

Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nat Neurosci 5:533-8 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC (1957) The interpretation of spike potentials of motoneurones. J Physiol 139:198-231 [PubMed]

Dodge FA, Cooley JW (1973) Action Potential of the Motorneuron. IBM J Res Dev 17:219-29 [Journal]

   Spinal Motor Neuron (Dodge, Cooley 1973) [Model]

Duflocq A, Le Bras B, Bullier E, Couraud F, Davenne M (2008) Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol Cell Neurosci 39:180-92 [PubMed]

Eccles JC (1957) The Physiology Of Nerve Cells

Engel D, Jonas P (2005) Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron 45:405-17 [PubMed]

FATT P (1957) Sequence of events in synaptic activation of a motoneurone. J Neurophysiol 20:61-80 [PubMed]

FUORTES MG, FRANK K, BECKER MC (1957) Steps in the production of motoneuron spikes. J Gen Physiol 40:735-52 [PubMed]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Howard A, Tamas G, Soltesz I (2005) Lighting the chandelier: new vistas for axo-axonic cells. Trends Neurosci 28:310-6 [PubMed]

Inda MC, DeFelipe J, Muñoz A (2006) Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proc Natl Acad Sci U S A 103:2920-5 [PubMed]

Kampa BM, Clements J, Jonas P, Stuart GJ (2004) Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. J Physiol 556:337-45 [Journal] [PubMed]

   Kinetic NMDA receptor model (Kampa et al 2004) [Model]

Kampa BM, Letzkus JJ, Stuart GJ (2006) Requirement of dendritic calcium spikes for induction of spike-timing-dependent synaptic plasticity. J Physiol 574:283-90 [PubMed]

Kaplan MR, Cho MH, Ullian EM, Isom LL, Levinson SR, Barres BA (2001) Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron 30:105-19 [PubMed]

Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [Journal] [PubMed]

   Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008) [Model]

Kole MH, Letzkus JJ, Stuart GJ (2007) Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron 55:633-47 [PubMed]

Kole MH, Stuart GJ (2008) Is action potential threshold lowest in the axon? Nat Neurosci 11:1253-5 [PubMed]

Komai S, Licznerski P, Cetin A, Waters J, Denk W, Brecht M, Osten P (2006) Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development. Nat Neurosci 9:1125-33 [PubMed]

Lorincz A, Nusser Z (2008) Cell-type-dependent molecular composition of the axon initial segment. J Neurosci 28:14329-40 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]

   Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   Pyramidal Neuron Deep, Superficial; Aspiny, Stellate (Mainen and Sejnowski 1996) [Model]

Markram H, Lubke J, Frotscher M, Sakmann B (1997) Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213-5 [PubMed]

McCormick DA, Shu Y, Yu Y (2007) Hodgkin and Huxley model still standing? Nature 445:E1-E2 [Journal] [PubMed]

   AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008) [Model]

Meeks JP, Mennerick S (2007) Action potential initiation and propagation in CA3 pyramidal axons. J Neurophysiol 97:3460-72 [PubMed]

Milojkovic BA, Wuskell JP, Loew LM, Antic SD (2005) Initiation of sodium spikelets in basal dendrites of neocortical pyramidal neurons. J Membr Biol 208:155-69 [PubMed]

Moore JW, Stockbridge N, Westerfield M (1983) On the site of impulse initiation in a neurone. J Physiol 336:301-11 [PubMed]

   Site of impulse initiation in a neuron (Moore et al 1983) [Model]

Naundorf B, Wolf F, Volgushev M (2006) Unique features of action potential initiation in cortical neurons. Nature 440:1060-3 [PubMed]

Palmer LM, Stuart GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. J Neurosci 26:1854-63 [PubMed]

Rapp M, Yarom Y, Segev I (1996) Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells. Proc Natl Acad Sci U S A 93:11985-90 [PubMed]

Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons. J Neurophysiol [Journal] [PubMed]

   Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) [Model]

Rush AM, Dib-Hajj SD, Waxman SG (2005) Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones. J Physiol 564:803-15 [PubMed]

Sather W, Dieudonne S, MacDonald JF, Ascher P (1992) Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J Physiol 450:643-72 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Hasenstaub A, McCormick DA (2003) Turning on and off recurrent balanced cortical activity. Nature 423:288-93 [PubMed]

Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A 104:11453-8 [Journal] [PubMed]

   Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007) [Model]

Sjostrom PJ, Turrigiano GG, Nelson SB (2001) Rate, timing, and cooperativity jointly determine cortical synaptic plasticity. Neuron 32:1149-64 [PubMed]

Steriade M, Nunez A, Amzica F (1993) 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 13:3252-65 [PubMed]

Stuart G, Schiller J, Sakmann B (1997) Action potential initiation and propagation in rat neocortical pyramidal neurons. J Physiol 505 ( Pt 3):617-32 [PubMed]

Stuart G, Spruston N, Sakmann B, Hausser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]

Van Wart A, Trimmer JS, Matthews G (2007) Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol 500:339-52 [PubMed]

Wollner DA, Catterall WA (1986) Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proc Natl Acad Sci U S A 83:8424-8 [PubMed]

Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [Journal] [PubMed]

   AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008) [Model]

Acker CD, Hoyos E, Loew LM (2016) EPSPs Measured in Proximal Dendritic Spines of Cortical Pyramidal Neurons. eNeuro [Journal] [PubMed]

Balbi P, Martinoia S, Massobrio P (2015) Axon-somatic back-propagation in detailed models of spinal alpha motoneurons Front. Comput. Neurosci. 9:15 [Journal]

   Axon-somatic back-propagation in a detailed model of cat spinal motoneuron (Balbi et al, 2015) [Model]

Balbi P, Massobrio P, Hellgren-Kotaleski J (2017) A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms PLOS Computational Biology 13(9):e1005737 [Journal] [PubMed]

   A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017) [Model]

Ben-Shalom R, Keeshen CM,Berrios KN, An JY, Sanders SJ, Bender KJ (2017) Opposing effects on NaV1.2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures Biological Psychiatry, epub before print [Journal]

   Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017) [Model]

Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma. Nat Neurosci 13:852-60 [Journal] [PubMed]

   Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010) [Model]

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA (2011) Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons The Journal of Neuroscience 31(43):15490-15498 [Journal] [PubMed]

   Spike repolarization in axon collaterals (Foust et al. 2011) [Model]

Foutz TJ, Arlow RL, McIntyre CC (2012) Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron J Neurophysiol. 107(12):3235-45 [Journal] [PubMed]

   Optical stimulation of a channelrhodopsin-2 positive pyramidal neuron model (Foutz et al 2012) [Model]

Grossman N, Simiaki V, Martinet C, Toumazou C, Schultz SR, Nikolic K (2012) The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials. J Comput Neurosci [Journal] [PubMed]

Hay E, Hill S, Schurmann F, Markram H, Segev I (2011) Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS Comput Biol 7:e1002107 [Journal] [PubMed]

   Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017) [Model]
   L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011) [Model]

Hay E, Schurmann F, Markram H, Segev I (2013) Preserving Axo-somatic Spiking Features Despite Diverse Dendritic Morphology. J Neurophysiol 109(12):2972-81 [Journal] [PubMed]

   Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013) [Model]

Hyun JH, Eom K, Lee KH, Bae JY, Bae YC, Kim MH, Kim S, Ho WK, Lee SH (2015) Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. J Physiol 593:3617-43 [Journal] [PubMed]

   CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015) [Model]

Neymotin SA, Suter BA, Dura-Bernal S, Shepherd GM, Migliore M, Lytton WW (2017) Optimizing computer models of corticospinal neurons to replicate in vitro dynamics. J Neurophysiol 117(1):148-162 [Journal] [PubMed]

   Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017) [Model]

Ona-Jodar T, Gerkau NJ, Aghvami SS, Rose CR, Egger V (2017) Two-Photon Na+ Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites Front. Cell. Neurosci. 11:50 [Journal]

   Na+ Signals in olfactory bulb neurons (granule cell model) (Ona-Jodar et al. 2017) [Model]

Oz P, Huang M, Wolf F (2015) Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. J Comput Neurosci 39:63-75 [Journal] [PubMed]

   MCCAIS model (multicompartmental cooperative AIS) (Öz et al 2015) [Model]

Parasuram H, Nair B, D`Angelo E, Hines M, Naldi G, Diwakar S (2016) Computational modeling of single neuron extracellular electric potentials and network Local Field Potentials using LFPsim Front. Comput. Neurosci. 10:65 [Journal]

   Modeling single neuron LFPs and extracellular potentials with LFPsim (Parasuram et al. 2016) [Model]

Platkiewicz J, Brette R (2010) A threshold equation for action potential initiation. PLoS Comput Biol 6:e1000850 [Journal] [PubMed]

   A threshold equation for action potential initiation (Platkiewicz & Brette 2010) [Model]

Platkiewicz J, Brette R (2011) Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration. PLoS Comput Biol 7:e1001129-78 [Journal] [PubMed]

   Impact of fast Na channel inact. on AP threshold & synaptic integration (Platkiewicz & Brette 2011) [Model]

Schmidt-Hieber C, Bischofberger J (2010) Fast Sodium Channel Gating Supports Localized and Efficient Axonal Action Potential Initiation J. Neurosci. 30(30):10233-10242 [Journal] [PubMed]

   Fast sodium channel gating in mossy fiber axons (Schmidt-Hieber et al. 2010) [Model]

Teka W, Stockton D, Santamaria F (2016) Power-law dynamics of membrane conductances increase spiking diversity in a Hodgkin-Huxley model PLoS Comput Biol 12(3):e1004776 [Journal]

   Hodgkin–Huxley model with fractional gating (Teka et al. 2016) [Model]

Vladimirov N, Tu Y, Traub RD (2013) Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study Eur J Neurosci. 38(10):3435-47 [Journal] [PubMed]

   Synaptic gating at axonal branches, and sharp-wave ripples with replay (Vladimirov et al. 2013) [Model]

Wenger C, Paredes L, Rattay F (2011) Current-distance relations for microelectrode stimulation of pyramidal cells. Artif Organs 35:263-6 [Journal] [PubMed]

Wilmes KA, Sprekeler H, Schreiber S (2016) Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons. PLoS Comput Biol 12:e1004768 [Journal] [PubMed]

   Inhibition of bAPs and Ca2+ spikes in a multi-compartment pyramidal neuron model (Wilmes et al 2016) [Model]

Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL, Royeck M, Horstmann M (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest 120:2661-71 [Journal] [PubMed]

   Complex CA1-neuron to study AP initiation (Wimmer et al. 2010) [Model]

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