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Kim M, Huang T, Abel T, Blackwell KT (2010) Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS Comput Biol 6:e1000691 [PubMed]

   Hippocampus CA1: Temporal sensitivity of signaling pathways underlying LTP (Kim et al. 2010)

References and models cited by this paper

References and models that cite this paper

Abel T, Nguyen PV, Barad M, Deuel TA, Kandel ER, Bourtchouladze R (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88:615-26 [PubMed]

Ajay SM, Bhalla US (2004) A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. Eur J Neurosci 20:2671-80 [Journal] [PubMed]

Ajay SM, Bhalla US (2007) A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP J 1:49-66 [Journal] [PubMed]

Barco A, Alarcon JM, Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108:689-703 [PubMed]

Bauman AL, Goehring AS, Scott JD (2004) Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology 46:299-310 [Journal] [PubMed]

Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283:381-7 [PubMed]

   Emergent properties of networks of biological signaling pathways (Bhalla, Iyengar 1999) [Model]

Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM (1998) Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science 280:1940-2 [PubMed]

Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM (2000) Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. J Neurosci 20:7880-7 [PubMed]

Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J (1994) Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. J Biol Chem 269:12190-5 [PubMed]

Castellani GC, Quinlan EM, Bersani F, Cooper LN, Shouval HZ (2005) A model of bidirectional synaptic plasticity: from signaling network to channel conductance. Learn Mem 12:423-32 [Journal] [PubMed]

Chakravarthy B, Morley P, Whitfield J (1999) Ca2+-calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains. Trends Neurosci 22:12-6 [PubMed]

Chetkovich DM, Sweatt JD (1993) nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. J Neurochem 61:1933-42 [PubMed]

Connor JH, Frederick D, Huang Hb, Yang J, Helps NR, Cohen PT, Nairn AC, DePaoli-Roach A, Tatchell K, Shenolikar S (2000) Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. J Biol Chem 275:18670-5 [Journal] [PubMed]

Coomber CJ (1998) Site-selective autophosphorylation of Ca2+/calmodulin-dependent protein kinase II as a synaptic encoding mechanism. Neural Comput 10:1653-78 [PubMed]

Corvol JC, Studler JM, Schonn JS, Girault JA, Hervé D (2001) Galpha(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. J Neurochem 76:1585-8 [PubMed]

D'Alcantara P, Schiffmann SN, Swillens S (2003) Bidirectional synaptic plasticity as a consequence of interdependent Ca2+-controlled phosphorylation and dephosphorylation pathways. Eur J Neurosci 17:2521-8 [PubMed]

De Koninck P, Schulman H (1998) Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science 279:227-30 [PubMed]

Dupont G, Houart G, De Koninck P (2003) Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model. Cell Calcium 34:485-97 [PubMed]

Frey U, Huang YY, Kandel ER (1993) Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260:1661-4 [PubMed]

Frey U, Morris RG (1997) Synaptic tagging and long-term potentiation. Nature 385:533-6 [Journal] [PubMed]

Frey U, Schroeder H, Matthies H (1990) Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain Res 522:69-75 [PubMed]

Giovannini MG, Blitzer RD, Wong T, Asoma K, Tsokas P, Morrison JH, Iyengar R, Landau EM (2001) Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation. J Neurosci 21:7053-62 [PubMed]

Granado N, Ortiz O, Suárez LM, Martín ED, Ceña V, Solís JM, Moratalla R (2008) D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus. Cereb Cortex 18:1-12 [Journal] [PubMed]

Harvey CD, Yasuda R, Zhong H, Svoboda K (2008) The spread of Ras activity triggered by activation of a single dendritic spine. Science 321:136-40 [Journal] [PubMed]

Hayer A, Bhalla US (2005) Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS Comput Biol 1:137-54 [Journal] [PubMed]

Herberg FW, Dostmann WR, Zorn M, Davis SJ, Taylor SS (1994) Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry 33:7485-94 [PubMed]

Herberg FW, Taylor SS, Dostmann WR (1996) Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry 35:2934-42 [Journal] [PubMed]

Hofmann F, Bechtel PJ, Krebs EG (1977) Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. J Biol Chem 252:1441-7 [PubMed]

Holmes WR (2000) Models of calmodulin trapping and CaM kinase II activation in a dendritic spine. J Comput Neurosci 8:65-85 [PubMed]

Huang CC, Liang YC, Hsu KS (2001) Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. J Biol Chem 276:48108-17 [Journal] [PubMed]

Huang HB, Horiuchi A, Watanabe T, Shih SR, Tsay HJ, Li HC, Greengard P, Nairn AC (1999) Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2. J Biol Chem 274:7870-8 [PubMed]

Huang KP, Huang FL, Jäger T, Li J, Reymann KG, Balschun D (2004) Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci 24:10660-9 [Journal] [PubMed]

Huang Q, Zhou D, Chase K, Gusella JF, Aronin N, DiFiglia M (1992) Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci U S A 89:11988-92 [PubMed]

Huang T, McDonough CB, Abel T (2006) Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation. Eur J Cell Biol 85:635-42 [Journal] [PubMed]

Huang YY, Kandel ER (1995) D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proc Natl Acad Sci U S A 92:2446-50 [PubMed]

Huang YY, Pittenger C, Kandel ER (2004) A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proc Natl Acad Sci U S A 101:859-64 [Journal] [PubMed]

Hudmon A, Schulman H (2002) Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annu Rev Biochem 71:473-510 [Journal] [PubMed]

Impey S, Obrietan K, Wong ST, Poser S, Yano S, Wayman G, Deloulme JC, Chan G, Storm DR (1998) Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21:869-83 [PubMed]

Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS (2001) Dynamics of cAMP-dependent protein kinase. Chem Rev 101:2243-70 [PubMed]

Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 142:436-40 [PubMed]

Kelly MT, Crary JF, Sacktor TC (2007) Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. J Neurosci 27:3439-44 [Journal] [PubMed]

Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE (2004) SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron 43:563-74 [Journal] [PubMed]

Kubota Y, Bower JM (2001) Transient versus asymptotic dynamics of CaM kinase II: possible roles of phosphatase. J Comput Neurosci 11:263-79 [PubMed]

Kubota Y, Putkey JA, Waxham MN (2007) Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling. Biophys J 93:3848-59 [Journal] [PubMed]

Lee HK (2006) Synaptic plasticity and phosphorylation. Pharmacol Ther 112:810-32 [Journal] [PubMed]

Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112:631-43 [PubMed]

Lee SJ, Escobedo-Lozoya Y, Szatmari EM, Yasuda R (2009) Activation of CaMKII in single dendritic spines during long-term potentiation. Nature 458:299-304 [Journal] [PubMed]

Lemon N, Manahan-Vaughan D (2006) Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. J Neurosci 26:7723-9 [Journal] [PubMed]

Lisman J (1989) A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc Natl Acad Sci U S A 86:9574-8 [PubMed]

Lisman JE, McIntyre CC (2001) Synaptic plasticity: a molecular memory switch. Curr Biol 11:R788-91 [PubMed]

Lisman JE, Zhabotinsky AM (2001) A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly. Neuron 31:191-201 [PubMed]

MacKenzie SJ, Baillie GS, McPhee I, MacKenzie C, Seamons R, McSorley T, Millen J, Beard MB, van Heeke G, Houslay MD (2002) Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). Br J Pharmacol 136:421-33 [Journal] [PubMed]

Malenka RC, Bear MF (2004) LTP and LTD: an embarrassment of riches. Neuron 44:5-21 [Journal] [PubMed]

Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711 [Journal] [PubMed]

Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G (2008) Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci U S A 105:506-11 [Journal] [PubMed]

Mullasseril P, Dosemeci A, Lisman JE, Griffith LC (2007) A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic density. J Neurochem 103:357-64 [Journal] [PubMed]

Navakkode S, Sajikumar S, Frey JU (2007) Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro. Neuropharmacology 52:1547-54 [Journal] [PubMed]

Nguyen PV, Abel T, Kandel ER (1994) Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104-7 [PubMed]

Nguyen PV, Kandel ER (1997) Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus. Learn Mem 4:230-43 [PubMed]

Nguyen PV, Woo NH (2003) Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog Neurobiol 71:401-37 [Journal] [PubMed]

Nie T, McDonough CB, Huang T, Nguyen PV, Abel T (2007) Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. J Neurosci 27:10278-88 [Journal] [PubMed]

O'Carroll CM, Morris RG (2004) Heterosynaptic co-activation of glutamatergic and dopaminergic afferents is required to induce persistent long-term potentiation. Neuropharmacology 47:324-32 [Journal] [PubMed]

Ogreid D, Døskeland SO (1981) The kinetics of association of cyclic AMP to the two types of binding sites associated with protein kinase II from bovine myocardium. FEBS Lett 129:287-92 [PubMed]

Ogreid D, Døskeland SO (1981) The kinetics of the interaction between cyclic AMP and the regulatory moiety of protein kinase II. Evidence for interaction between the binding sites for cyclic AMP. FEBS Lett 129:282-6 [PubMed]

Ogreid D, Døskeland SO (1982) Activation of protein kinase isoenzymes under near physiological conditions. Evidence that both types (A and B) of cAMP binding sites are involved in the activation of protein kinase by cAMP and 8-N3-cAMP. FEBS Lett 150:161-6 [PubMed]

Pantano S, Zaccolo M, Carloni P (2005) Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit. FEBS Lett 579:2679-85 [Journal] [PubMed]

Petrozzino JJ, Pozzo Miller LD, Connor JA (1995) Micromolar Ca2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice. Neuron 14:1223-31 [PubMed]

Ponsioen B, Zhao J, Riedl J, Zwartkruis F, van der Krogt G, Zaccolo M, Moolenaar WH, Bos JL, Jalink K (2004) Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep 5:1176-80 [Journal] [PubMed]

Rice ME, Cragg SJ (2004) Nicotine amplifies reward-related dopamine signals in striatum. Nat Neurosci 7:583-4 [Journal] [PubMed]

Sabatini BL, Oertner TG, Svoboda K (2002) The life cycle of Ca(2+) ions in dendritic spines. Neuron 33:439-52 [PubMed]

Sajikumar S, Navakkode S, Frey JU (2007) Identification of compartment- and process-specific molecules required for "synaptic tagging" during long-term potentiation and long-term depression in hippocampal CA1. J Neurosci 27:5068-80 [Journal] [PubMed]

Scharf MT, Woo NH, Lattal KM, Young JZ, Nguyen PV, Abel T (2002) Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training. J Neurophysiol 87:2770-7 [Journal] [PubMed]

Scheuss V, Yasuda R, Sobczyk A, Svoboda K (2006) Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion. J Neurosci 26:8183-94 [Journal] [PubMed]

Shouval HZ, Bear MF, Cooper LN (2002) A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proc Natl Acad Sci U S A 99:10831-6 [Journal] [PubMed]

Soulsby MD, Wojcikiewicz RJ (2005) The type III inositol 1,4,5-trisphosphate receptor is phosphorylated by cAMP-dependent protein kinase at three sites. Biochem J 392:493-7 [Journal] [PubMed]

Stenesh J (1993) Core Topic in Biochemistry :282-289

Sweatt JD (2004) Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol 14:311-7 [Journal] [PubMed]

Verney C, Baulac M, Berger B, Alvarez C, Vigny A, Helle KB (1985) Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience 14:1039-52 [PubMed]

Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J (2004) Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry 43:5629-36 [Journal] [PubMed]

Wang H, Storm DR (2003) Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system. Mol Pharmacol 63:463-8 [PubMed]

Willoughby D, Cooper DM (2006) Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP. J Cell Sci 119:828-36 [Journal] [PubMed]

Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC, Muglia LJ, Storm DR (1999) Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23:787-98 [PubMed]

Woo NH, Abel T, Nguyen PV (2002) Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP. Eur J Neurosci 16:1871-6 [PubMed]

Woo NH, Duffy SN, Abel T, Nguyen PV (2003) Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase. Hippocampus 13:293-300 [Journal] [PubMed]

Young JZ, Isiegas C, Abel T, Nguyen PV (2006) Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging. Eur J Neurosci 23:1784-94 [Journal] [PubMed]

Zawadzki KM, Taylor SS (2004) cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem 279:7029-36 [Journal] [PubMed]

Zhabotinsky AM (2000) Bistability in the Ca(2+)/calmodulin-dependent protein kinase-phosphatase system. Biophys J 79:2211-21 [Journal] [PubMed]

Zhabotinsky AM, Camp RN, Epstein IR, Lisman JE (2006) Role of the neurogranin concentrated in spines in the induction of long-term potentiation. J Neurosci 26:7337-47 [Journal] [PubMed]

Evans RC, Maniar YM, Blackwell KT (2013) Dynamic modulation of spike timing-dependent calcium influx during corticostriatal upstates. J Neurophysiol 110:1631-45 [Journal] [PubMed]

   Calcium influx during striatal upstates (Evans et al. 2013) [Model]

Fridlyand LE, Philipson LH (2016) Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One 11:e0152869 [Journal] [PubMed]

   Pancreatic Beta Cell signalling pathways (Fridlyand & Philipson 2016) (MATLAB) [Model]

J?drzejewska-Szmek J, Luczak V, Abel T, Blackwell KT (2017) ß-adrenergic signaling broadly contributes to LTP induction. PLoS Comput Biol 13:e1005657 [Journal] [PubMed]

   Signaling pathways underlying LTP in hippocampal CA1 pyramidal cells (Jedrzejewska-Szmek et al 2017) [Model]

Kim M, Park AJ, Havekes R, Chay A, Guercio LA, Oliveira RF, Abel T, Blackwell KT (2011) Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS Comput Biol 7:e1002084 [Journal] [PubMed]

   Hippocampus CA1: Simulations of LTP signaling pathways (Kim M et al. 2011) [Model]

Manninen T, Hituri K, Kotaleski JH, Blackwell KT, Linne ML (2010) Postsynaptic signal transduction models for long-term potentiation and depression. Front Comput Neurosci 4:152 [Journal] [PubMed]

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