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Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011) Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. J Neurophysiol 105:1546-57 [PubMed]

   HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)

References and models cited by this paper

References and models that cite this paper

Akaike H (1974) A new look at the statistical model identification IEEE Trans Appl Comp 19:716-723

Armstrong CM (2006) Na channel inactivation from open and closed states. Proc Natl Acad Sci U S A 103:17991-6 [Journal] [PubMed]

Armstrong CM, Bezanilla F (1977) Inactivation of the sodium channel. II. Gating current experiments. J Gen Physiol 70:567-90 [PubMed]

Armstrong CM, Bezanilla F, Rojas E (1973) Destruction of sodium conductance inactivation in squid axons perfused with pronase. J Gen Physiol 62:375-91 [PubMed]

Armstrong CM, Hille B (1998) Voltage-gated ion channels and electrical excitability. Neuron 20:371-80 [PubMed]

Baranauskas G, Martina M (2006) Sodium currents activate without a Hodgkin-and-Huxley-type delay in central mammalian neurons. J Neurosci 26:671-84 [Journal] [PubMed]

   Sodium currents activate without a delay (Baranauskas and Martina 2006) [Model]

Bean BP (2005) The molecular machinery of resurgent sodium current revealed. Neuron 45:185-7 [Journal] [PubMed]

Bezanilla F, Armstrong CM (1974) Gating currents of the sodium channels: three ways to block them. Science 183:753-4 [PubMed]

Blair NT, Bean BP (2002) Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. J Neurosci 22:10277-90 [PubMed]

Catterall WA (2000) From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26:13-25 [PubMed]

Cestèle S, Yarov-Yarovoy V, Qu Y, Sampieri F, Scheuer T, Catterall WA (2006) Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem 281:21332-44 [Journal] [PubMed]

Chanda B, Asamoah OK, Bezanilla F (2004) Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol 123:217-30 [Journal] [PubMed]

Chanda B, Bezanilla F (2002) Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. J Gen Physiol 120:629-45 [PubMed]

Clancy CE, Kass RS (2004) Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophys J 86:2606-14 [Journal] [PubMed]

   Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004) [Model]

Clancy CE, Rudy Y (2002) Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation 105:1208-13 [PubMed]

   Markovian model for cardiac sodium channel (Clancy, Rudy 2002) [Model]

Colquhoun D, Dowsland KA, Beato M, Plested AJ (2004) How to impose microscopic reversibility in complex reaction mechanisms. Biophys J 86:3510-8 [Journal] [PubMed]

Cummins TR, Howe JR, Waxman SG (1998) Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J Neurosci 18:9607-19 [PubMed]

Cummins TR, Rush AM, Estacion M, Dib-Hajj SD, Waxman SG (2009) Voltage-clamp and current-clamp recordings from mammalian DRG neurons. Nat Protoc 4:1103-12 [Journal] [PubMed]

Cummins TR, Zhou J, Sigworth FJ, Ukomadu C, Stephan M, Ptácek LJ, Agnew WS (1993) Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis. Neuron 10:667-78 [PubMed]

Dib-Hajj SD, Cummins TR, Black JA, Waxman SG (2010) Sodium channels in normal and pathological pain. Annu Rev Neurosci 33:325-47 [Journal] [PubMed]

Dib-Hajj SD, Rush AM, Cummins TR, Hisama FM, Novella S, Tyrrell L, Marshall L, Waxman SG (2005) Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain 128:1847-54 [Journal] [PubMed]

Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69-77 [PubMed]

Faber GM, Rudy Y (2000) Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophys J 78:2392-404 [Journal] [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Goldman L, Schauf CL (1972) Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process. J Gen Physiol 59:659-75 [PubMed]

Gonoi T, Hille B (1987) Gating of Na channels. Inactivation modifiers discriminate among models. J Gen Physiol 89:253-74 [PubMed]

Gurkiewicz M, Korngreen A (2007) A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm. PLoS Comput Biol 3:e169 [Journal] [PubMed]

   Ion channel modeling with whole cell and a genetic algorithm (Gurkiewicz and Korngreen 2007) [Model]

Han C, Dib-Hajj SD, Lin Z, Li Y, Eastman EM, Tyrrell L, Cao X, Yang Y, Waxman SG (2009) Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain 132:1711-22 [Journal] [PubMed]

Harty TP, Dib-Hajj SD, Tyrrell L, Blackman R, Hisama FM, Rose JB, Waxman SG (2006) Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. J Neurosci 26:12566-75 [Journal] [PubMed]

HODGKIN AL, HUXLEY AF, KATZ B (1952) Measurement of current-voltage relations in the membrane of the giant axon of Loligo. J Physiol 116:424-48 [PubMed]

Horn R (1987) Statistical methods for model discrimination. Applications to gating kinetics and permeation of the acetylcholine receptor channel. Biophys J 51:255-63 [Journal] [PubMed]

Huth T, Schmidtmayer J, Alzheimer C, Hansen UP (2008) Four-mode gating model of fast inactivation of sodium channel Nav1.2a. Pflugers Arch 457:103-19 [Journal] [PubMed]

Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R (2002) The open pore conformation of potassium channels. Nature 417:523-6 [Journal] [PubMed]

Keren N, Bar-Yehuda D, Korngreen A (2009) Experimentally guided modelling of dendritic excitability in rat neocortical pyramidal neurones. J Physiol 587:1413-37 [Journal] [PubMed]

Korngreen A, Sakmann B (2000) Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. J Physiol 525 Pt 3:621-39 [PubMed]

   Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000) [Model]

Lampert A, O'Reilly AO, Dib-Hajj SD, Tyrrell L, Wallace BA, Waxman SG (2008) A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation. J Biol Chem 283:24118-27 [Journal] [PubMed]

Lampert A, O'Reilly AO, Reeh P, Leffler A (2010) Sodium channelopathies and pain. Pflugers Arch 460:249-63 [Journal] [PubMed]

Lipkind GM, Fozzard HA (2008) Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue. J Gen Physiol 131:523-9 [Journal] [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]

   Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]

Menon V, Spruston N, Kath WL (2009) A state-mutating genetic algorithm to design ion-channel models. Proc Natl Acad Sci U S A 106:16829-34 [Journal] [PubMed]

   Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009) [Model]

Milescu LS, Yamanishi T, Ptak K, Mogri MZ, Smith JC (2008) Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophys J 95:66-87 [Journal] [PubMed]

Mitchell M (1996) An Introduction to Genetic Algorithms

O'Reilly AO, Khambay BP, Williamson MS, Field LM, Wallace BA, Davies TG (2006) Modelling insecticide-binding sites in the voltage-gated sodium channel. Biochem J 396:255-63 [Journal] [PubMed]

Patlak J (1991) Molecular kinetics of voltage-dependent Na+ channels. Physiol Rev 71:1047-80 [Journal] [PubMed]

Petitprez S, Jespersen T, Pruvot E, Keller DI, Corbaz C, Schläpfer J, Abriel H, Kucera JP (2008) Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovasc Res 78:494-504 [Journal] [PubMed]

Press WH (2002) Numerical recipes in C++ : the art of scientific computing :1-1002

Raman IM, Bean BP (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 17:4517-26 [PubMed]

Renganathan M, Cummins TR, Waxman SG (2001) Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol 86:629-40 [Journal] [PubMed]

Ruan Y, Denegri M, Liu N, Bachetti T, Seregni M, Morotti S, Severi S, Napolitano C, Priori SG (2010) Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3. Circ Res 106:1374-83 [Journal] [PubMed]

Rudy B (1978) Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance. J Physiol 283:1-21 [PubMed]

Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG (2006) A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A 103:8245-50 [Journal] [PubMed]

Scheib H, McLay I, Guex N, Clare JJ, Blaney FE, Dale TJ, Tate SN, Robertson GM (2006) Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding. J Mol Model 12:813-22 [Journal] [PubMed]

Sheets PL, Jackson JO, Waxman SG, Dib-Hajj SD, Cummins TR (2007) A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol 581:1019-31 [Journal] [PubMed]

Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R (2010) A gating charge transfer center in voltage sensors. Science 328:67-73 [Journal] [PubMed]

ten Tusscher KH, Panfilov AV (2006) Alternans and spiral breakup in a human ventricular tissue model. Am J Physiol Heart Circ Physiol 291:H1088-100 [Journal] [PubMed]

Thomas EA, Reid CA, Petrou S (2010) Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia 51:136-45 [Journal] [PubMed]

   Na channel mutations in the dentate gyrus (Thomas et al. 2009) [Model]

Thomas EA, Xu R, Petrou S (2007) Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience 147:1034-46 [Journal] [PubMed]

Tikhonov DB, Zhorov BS (2005) Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophys J 88:184-97 [Journal] [PubMed]

Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A (2009) Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A 106:6644-9 [Journal] [PubMed]

Vandenberg CA, Bezanilla F (1991) A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon. Biophys J 60:1511-33 [Journal] [PubMed]

Vecchietti S, Grandi E, Severi S, Rivolta I, Napolitano C, Priori SG, Cavalcanti S (2007) In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. Am J Physiol Heart Circ Physiol 292:H56-65 [Journal] [PubMed]

Yang Y, Wang Y, Li S, Xu Z, Li H, Ma L, Fan J, Bu D, Liu B, Fan Z, Wu G, Jin J, Ding B, Zhu X, Shen Y (2004) Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet 41:171-4 [PubMed]

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