Citation Relationships



Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL, Royeck M, Horstmann M (2010) Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus. J Clin Invest 120:2661-71[PubMed]

   Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)

References and models cited by this paper

References and models that cite this paper

Abramoff MD, Magelhaes PJ, Ram SJ (2004) Image Processing with ImageJ Biophotonics Int 11:36-42

Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL, Raman IM (2009) Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels. J Neurosci 29:2027-42 [PubMed]

Audenaert D, Claes L, Ceulemans B, Lofgren A, Van Broeckhoven C, De Jonghe P (2003) A deletion in SCN1B is associated with febrile seizures and early-onset absence epilepsy. Neurology 61:854-6 [PubMed]

Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A (2006) An Epilepsy Mutation in the Sodium Channel SCN1A That Decreases Channel Excitability J. Neurosci. 26(10):2714-2723 [PubMed]

   Sodium channel mutations causing generalized epilepsy with febrile seizures + (Barela et al. 2006) [Model]

Bender KJ, Trussell LO (2009) Axon initial segment Ca2+ channels influence action potential generation and timing. Neuron 61:259-71 [PubMed]

Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL (2010) Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A 107:2283-8 [PubMed]

Brackenbury WJ, Djamgoz MB, Isom LL (2008) An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers. Neuroscientist 14:571-83 [PubMed]

Brackenbury WJ, Isom LL (2008) Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. Expert Opin Ther Targets 12:1191-203 [PubMed]

Carnevale NT, Hines ML (2006) The NEURON Book

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharuc (2004) Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24:4030-42 [PubMed]

Christie SB, De Blas AL (2003) GABAergic and glutamatergic axons innervate the axon initial segment and organize GABA(A) receptor clusters of cultured hippocampal pyramidal cells. J Comp Neurol 456:361-74 [PubMed]

Cooper DC, Chung S, Spruston N (2005) Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS Biol 3:e175-8 [PubMed]

Devaux JJ, Kleopa KA, Cooper EC, Scherer SS (2004) KCNQ2 is a nodal K+ channel. J Neurosci 24:1236-44 [PubMed]

Dube C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ (2006) Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain 129:911-22

Duflocq A, Le Bras B, Bullier E, Couraud F, Davenne M (2008) Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol Cell Neurosci 39:180-92 [PubMed]

Ernst SJ, Aguilar-Bryan L, Noebels JL (2009) Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology 150:1132-9 [PubMed]

Fry M, Porter DM, Maue RA (2003) Adenoviral-mediated expression of functional Na+ channel beta1 subunits tagged with a yellow fluorescent protein. J Neurosci Res 74:794-800 [PubMed]

Garrido JJ, Fernandes F, Moussif A, Fache MP, Giraud P, Dargent B (2003) Dynamic compartmentalization of the voltage-gated sodium channels in axons. Biol Cell 95:437-45 [PubMed]

Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [Journal] [PubMed]

   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA (1995) Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. J Biol Chem 270:3306-12 [PubMed]

Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [Journal] [PubMed]

   Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008) [Model]

Kress GJ, Dowling MJ, Eisenman LN, Mennerick S (2010) Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons. Hippocampus 20:558-71 [PubMed]

Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-76 [PubMed]

Lorincz A, Nusser Z (2008) Cell-type-dependent molecular composition of the axon initial segment. J Neurosci 28:14329-40 [PubMed]

McEwen DP, Isom LL (2004) Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules. J Biol Chem 279:52744-52 [PubMed]

McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL (2004) Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin. J Biol Chem 279:16044-9 [PubMed]

Meadows LS, Malhotra J, Loukas A, Thyagarajan V, Kazen-Gillespie KA, Koopman MC, Kriegler S, (2002) Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J Neurosci 22:10699-709 [PubMed]

Meeks JP, Mennerick S (2007) Action potential initiation and propagation in CA3 pyramidal axons. J Neurophysiol 97:3460-72 [PubMed]

Morimoto T, Nagao H, Sano N, Takahashi M, Matsuda H (2006) Electroencephalographic study of rat hyperthermic seizures. Epilepsia 32:289-93 [PubMed]

Moulding HD, Martuza RL, Rabkin SD (2000) Clinical mutations in the L1 neural cell adhesion molecule affect cell-surface expression. J Neurosci 20:5696-702 [PubMed]

Oakley JC, Kalume F, Yu FH, Scheuer T, Catterall WA (2009) Temperature- and age-dependent seizures in a mouse model of severe myoclonic epilepsy in infancy. Proc Natl Acad Sci U S A 106:3994-9 [PubMed]

Ogawa Y, Rasband MN (2008) The functional organization and assembly of the axon initial segment. Curr Opin Neurobiol 18:307-13 [PubMed]

Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagaw (2007) Na(v)1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci 27:5903-14 [PubMed]

Palmer LM, Stuart GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. J Neurosci 26:1854-63 [PubMed]

Papale LA, Beyer B, Jones JM, Sharkey LM, Tufik S, Epstein M, Letts VA, Meisler MH, Frankel W (2009) Heterozygous mutations of the voltage-gated sodium channel SCN8A are associated with spike-wave discharges and absence epilepsy in mice. Hum Mol Genet 18:1633-41 [PubMed]

Patino GA, Claes LR, Lopez-Santiago LF, Slat EA, Dondeti RS, Chen C, O'Malley HA, Gray CB, Mi (2009) A functional null mutation of SCN1B in a patient with Dravet syndrome. J Neurosci 29:10764-78 [PubMed]

Qu Y, Curtis R, Lawson D, Gilbride K, Ge P, DiStefano PS, Silos-Santiago I, Catterall WA, Sch (2001) Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Mol Cell Neurosci 18:570-80 [PubMed]

Qu Y, Rogers JC, Chen SF, McCormick KA, Scheuer T, Catterall WA (1999) Functional roles of the extracellular segments of the sodium channel alpha subunit in voltage-dependent gating and modulation by beta1 subunits. J Biol Chem 274:32647-54 [PubMed]

Ratcliffe CF, Westenbroek RE, Curtis R, Catterall WA (2001) Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain. J Cell Biol 154:427-34 [PubMed]

Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons. J Neurophysiol [Journal] [PubMed]

   Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) [Model]

Scheffer IE, Harkin LA, Grinton BE, Dibbens LM, Turner SJ, Zielinski MA, Xu R, Jackson G, Ada (2007) Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain 130:100-9 [PubMed]

Scheffer IE, Zhang YH, Jansen FE, Dibbens L (2009) Dravet syndrome or genetic (generalized) epilepsy with febrile seizures plus? Brain Dev 31:394-400 [PubMed]

Shaner NC, Campbell RE, Steinbach PA, Giepmans BN, Palmer AE, Tsien RY (2004) Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 22:1567-72 [PubMed]

Spampanato J, Kearney JA, de Haan G, McEwen DP, Escayg A, Aradi I, MacDonald BT, Levin SI, So (2004) A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction. J Neurosci 24:10022-34 [PubMed]

Stuart G, Hausser M (1994) Initiation and spread of sodium action potentials in cerebellar Purkinje cells. Neuron 13:703-12 [PubMed]

Tang B, Dutt K, Papale L, Rusconi R, Shankar A, Hunter J, Tufik S, Yu FH, Catterall WA, Mante (2009) A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol Dis 35:91-102 [PubMed]

Thomas EA, Hawkins RJ, Richards KL, Xu R, Gazina EV, Petrou S (2009) Heat opens axon initial segment sodium channels: a febrile seizure mechanism? Ann Neurol 66:219-26 [PubMed]

Thomas EA, Xu R, Petrou S (2007) Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience 147:1034-46 [PubMed]

Van Wart A, Trimmer JS, Matthews G (2007) Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol 500:339-52 [PubMed]

Wallace RH, Wang DW, Singh R, Scheffer IE, George AL, Phillips HA, Saar K, Reis A, Johnson EW (1998) Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 19:366-70 [PubMed]

Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, (2008) Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 118:2260-8 [PubMed]

Wimmer VC, Nevian T, Kuner T (2004) Targeted in vivo expression of proteins in the calyx of Held. Pflugers Arch 449:319-33 [PubMed]

Wimmer VC, Reid CA, So EY, Berkovic SF, Petrou S (2010) Axon initial segment dysfunction in epilepsy. J Physiol 588:1829-40

Xiao ZC, Ragsdale DS, Malhotra JD, Mattei LN, Braun PE, Schachner M, Isom LL (1999) Tenascin-R is a functional modulator of sodium channel beta subunits. J Biol Chem 274:26511-7 [PubMed]

Xu R, Thomas EA, Gazina EV, Richards KL, Quick M, Wallace RH, Harkin LA, Heron SE, Berkovic S (2007) Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience 148:164-74 [PubMed]

Yu FH, Mantegazza M, Westenbroek RE, Robbins CA, Kalume F, Burton KA, Spain WJ, McKnight GS, (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci 9:1142-9 [PubMed]

Zhou W, Goldin AL (2004) Use-dependent potentiation of the Nav1.6 sodium channel. Biophys J 87:3862-72 [PubMed]

(57 refs)