Citation Relationships



Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y (2011) Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. PLoS Comput Biol 7:e1002149 [PubMed]

References and models cited by this paper

References and models that cite this paper

Asiedu M, Ossipov MH, Kaila K, Price TJ (2010) Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain 148:302-8 [Journal] [PubMed]

Balena T, Acton BA, Koval D, Woodin MA (2008) Extracellular potassium regulates the chloride reversal potential in cultured hippocampal neurons. Brain Res 1205:12-20 [Journal] [PubMed]

Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ (2004) Potassium model for slow (2-3 Hz) in vivo neocortical paroxysmal oscillations. J Neurophysiol 92:1116-32 [Journal] [PubMed]

Berglund K, Schleich W, Krieger P, Loo LS, Wang D, Cant NB, Feng G, Augustine GJ, Kuner T (2006) Imaging synaptic inhibition in transgenic mice expressing the chloride indicator, Clomeleon. Brain Cell Biol 35:207-28 [Journal] [PubMed]

Berglund K, Schleich W, Wang H, Feng G, Hall WC, Kuner T, Augustine GJ (2008) Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon. Brain Cell Biol 36:101-18 [Journal] [PubMed]

Blaesse P, Airaksinen MS, Rivera C, Kaila K (2009) Cation-chloride cotransporters and neuronal function. Neuron 61:820-38 [Journal] [PubMed]

Blaesse P, Guillemin I, Schindler J, Schweizer M, Delpire E, Khiroug L, Friauf E, Nothwang HG (2006) Oligomerization of KCC2 correlates with development of inhibitory neurotransmission. J Neurosci 26:10407-19 [Journal] [PubMed]

Brumback AC, Staley KJ (2008) Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons. J Neurosci 28:1301-12 [Journal] [PubMed]

Buhl EH, Tamás G, Szilágyi T, Stricker C, Paulsen O, Somogyi P (1997) Effect, number and location of synapses made by single pyramidal cells onto aspiny interneurones of cat visual cortex. J Physiol 500 ( Pt 3):689-713 [PubMed]

Buzsáki G, Kaila K, Raichle M (2007) Inhibition and brain work. Neuron 56:771-83 [Journal] [PubMed]

Carnevale NT, Hines ML (2006) The NEURON Book [Journal]

Chabwine JN, Van Damme P, Eggermont J, De Smedt H, Missiaen L, Van Den Bosch L, Parys JB, Robberecht W, Callewaert G (2004) Long-lasting changes in GABA responsiveness in cultured neurons. Neurosci Lett 365:69-72 [Journal] [PubMed]

Clay JR (1998) Excitability of the squid giant axon revisited. J Neurophysiol 80:903-13 [Journal] [PubMed]

Cordero-Erausquin M, Coull JA, Boudreau D, Rolland M, De Koninck Y (2005) Differential maturation of GABA action and anion reversal potential in spinal lamina I neurons: impact of chloride extrusion capacity. J Neurosci 25:9613-23 [Journal] [PubMed]

Costantino S, Kent CB, Godin AG, Kennedy TE, Wiseman PW, Fournier AE (2008) Semi-automated quantification of filopodial dynamics. J Neurosci Methods 171:165-73 [Journal] [PubMed]

Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-21 [Journal] [PubMed]

Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y (2003) Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424:938-42 [Journal] [PubMed]

De Koninck Y (2007) Altered chloride homeostasis in neurological disorders: a new target. Curr Opin Pharmacol 7:93-9 [Journal] [PubMed]

De Koninck Y, Mody I (1994) Noise analysis of miniature IPSCs in adult rat brain slices: properties and modulation of synaptic GABAA receptor channels. J Neurophysiol 71:1318-35 [Journal] [PubMed]

Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y (2009) Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol 296:H1017-26 [Journal] [PubMed]

Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD (2009) Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A 106:5383-8 [Journal] [PubMed]

Destexhe A, Paré D (1999) Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo. J Neurophysiol 81:1531-47 [Journal] [PubMed]

Destexhe A, Rudolph M, Paré D (2003) The high-conductance state of neocortical neurons in vivo. Nat Rev Neurosci 4:739-51 [Journal] [PubMed]

Duebel J, Haverkamp S, Schleich W, Feng G, Augustine GJ, Kuner T, Euler T (2006) Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron 49:81-94 [Journal] [PubMed]

Dzhala VI, Staley KJ (2003) Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J Neurosci 23:1840-6 [PubMed]

Fröhlich F, Bazhenov M, Iragui-Madoz V, Sejnowski TJ (2008) Potassium dynamics in the epileptic cortex: new insights on an old topic. Neuroscientist 14:422-33 [Journal] [PubMed]

Gilbert D, Franjic-Würtz C, Funk K, Gensch T, Frings S, Möhrlen F (2007) Differential maturation of chloride homeostasis in primary afferent neurons of the somatosensory system. Int J Dev Neurosci 25:479-89 [Journal] [PubMed]

Glickfeld LL, Roberts JD, Somogyi P, Scanziani M (2009) Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. Nat Neurosci 12:21-3 [Journal] [PubMed]

Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ (2009) Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron 63:657-72 [Journal] [PubMed]

Glykys J, Staley KJ (2008) Differences in cortical vs. subcortical GABA effects: A mechanism for electroclinical dissociation of neonatal seizures Epilepsia 49:170

Godin AG, Costantino S, Lorenzo LE, Swift JL, Sergeev M, Ribeiro-da-Silva A, De Koninck Y, Wiseman PW (2011) Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis. Proc Natl Acad Sci U S A 108:7010-5 [Journal] [PubMed]

Grob M, Mouginot D (2005) Heterogeneous chloride homeostasis and GABA responses in the median preoptic nucleus of the rat. J Physiol 569:885-901 [Journal] [PubMed]

Gulácsi A, Lee CR, Sík A, Viitanen T, Kaila K, Tepper JM, Freund TF (2003) Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra. J Neurosci 23:8237-46 [PubMed]

Gulledge AT, Stuart GJ (2003) Excitatory actions of GABA in the cortex. Neuron 37:299-309 [PubMed]

Gulyás AI, Sík A, Payne JA, Kaila K, Freund TF (2001) The KCl cotransporter, KCC2, is highly expressed in the vicinity of excitatory synapses in the rat hippocampus. Eur J Neurosci 13:2205-17 [PubMed]

Häusser M, Major G, Stuart GJ (2001) Differential shunting of EPSPs by action potentials. Science 291:138-41 [Journal] [PubMed]

Hewitt SA, Wamsteeker JI, Kurz EU, Bains JS (2009) Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis. Nat Neurosci 12:438-43 [Journal] [PubMed]

Hille B (2001) Ionic Channels of Excitable Membranes

Holmgren CD, Mukhtarov M, Malkov AE, Popova IY, Bregestovski P, Zilberter Y (2010) Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro. J Neurochem 112:900-12 [Journal] [PubMed]

Huberfeld G, Wittner L, Clemenceau S, Baulac M, Kaila K, Miles R, Rivera C (2007) Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy. J Neurosci 27:9866-73 [Journal] [PubMed]

Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P (2005) A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci 25:6971-83 [Journal] [PubMed]

Jedlicka P, Deller T, Gutkin BS, Backus KH (2011) Activity-dependent intracellular chloride accumulation and diffusion controls GABA(A) receptor-mediated synaptic transmission. Hippocampus 21:885-98 [Journal] [PubMed]

   Effects of Chloride accumulation and diffusion on GABAergic transmission (Jedlicka et al 2011) [Model]

Jorgensen PL, Hakansson KO, Karlish SJ (2003) Structure and mechanism of Na,K-ATPase: functional sites and their interactions. Annu Rev Physiol 65:817-49 [Journal] [PubMed]

Kahle KT, Staley KJ (2008) The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus 25:E22 [Journal] [PubMed]

Kaila K (1994) Ionic basis of GABAA receptor channel function in the nervous system. Prog Neurobiol 42:489-537 [PubMed]

Kaila K, Panula P, Karhunen T, Heinonen E (1991) Fall in intracellular pH mediated by GABAA receptors in cultured rat astrocytes. Neurosci Lett 126:9-12 [PubMed]

Kaila K, Pasternack M, Saarikoski J, Voipio J (1989) Influence of GABA-gated bicarbonate conductance on potential, current and intracellular chloride in crayfish muscle fibres. J Physiol 416:161-81 [PubMed]

Kaila K, Voipio J (1987) Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330:163-5 [Journal] [PubMed]

Kaila K, Voipio J, Paalasmaa P, Pasternack M, Deisz RA (1993) The role of bicarbonate in GABAA receptor-mediated IPSPs of rat neocortical neurones. J Physiol 464:273-89 [PubMed]

Katsura K, Mellergård P, Theander S, Ouyang YB, Siesjö BK (1993) Buffer capacity of rat cortical tissue as well as of cultured neurons and astrocytes. Brain Res 618:283-94 [PubMed]

Kersh AE, Hartzler LK, Havlin K, Hubbell BB, Nanagas V, Kalra A, Chua J, Whitesell R, Ritucci NA, Dean JB, Putnam RW (2009) pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. Am J Physiol Regul Integr Comp Physiol 297:R1409-20 [Journal] [PubMed]

Khirug S, Yamada J, Afzalov R, Voipio J, Khiroug L, Kaila K (2008) GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J Neurosci 28:4635-9 [Journal] [PubMed]

Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU (2008) Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 451:330-4 [Journal] [PubMed]

Li H, Khirug S, Cai C, Ludwig A, Blaesse P, Kolikova J, Afzalov R, Coleman SK, Lauri S, Airaksinen MS, Keinänen K, Khiroug L, Saarma M, Kaila K, Rivera C (2007) KCC2 interacts with the dendritic cytoskeleton to promote spine development. Neuron 56:1019-33 [Journal] [PubMed]

Lindskog S, Coleman JE (1973) The catalytic mechanism of carbonic anhydrase. Proc Natl Acad Sci U S A 70:2505-8 [PubMed]

Livshitz LM, Rudy Y (2007) Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents. Am J Physiol Heart Circ Physiol 292:H2854-66 [Journal] [PubMed]

Lopreore CL, Bartol TM, Coggan JS, Keller DX, Sosinsky GE, Ellisman MH, Sejnowski TJ (2008) Computational modeling of three-dimensional electrodiffusion in biological systems: application to the node of Ranvier. Biophys J 95:2624-35 [Journal] [PubMed]

Otis TS, De Koninck Y, Mody I (1993) Characterization of synaptically elicited GABAB responses using patch-clamp recordings in rat hippocampal slices. J Physiol 463:391-407 [PubMed]

Otis TS, Staley KJ, Mody I (1991) Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res 545:142-50 [PubMed]

Parker GW (2002) Electric field outside a parallel plate capacitor Am J Phys 70:502-507

Pasternack M, Voipio J, Kaila K (1993) Intracellular carbonic anhydrase activity and its role in GABA-induced acidosis in isolated rat hippocampal pyramidal neurones. Acta Physiol Scand 148:229-31 [Journal] [PubMed]

Payne JA, Rivera C, Voipio J, Kaila K (2003) Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci 26:199-206 [Journal] [PubMed]

Prescott SA, Sejnowski TJ, De Koninck Y (2006) Reduction of anion reversal potential subverts the inhibitory control of firing rate in spinal lamina I neurons: towards a biophysical basis for neuropathic pain. Mol Pain 2:32 [Journal] [PubMed]

Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA (2009) Chloride regulation in the pain pathway. Brain Res Rev 60:149-70 [Journal] [PubMed]

Qian N, Sejnowski TJ (1990) When is an inhibitory synapse effective? Proc Natl Acad Sci U S A 87:8145-9 [PubMed]

Rheims S, Holmgren CD, Chazal G, Mulder J, Harkany T, Zilberter T, Zilberter Y (2009) GABA action in immature neocortical neurons directly depends on the availability of ketone bodies. J Neurochem 110:1330-8 [Journal] [PubMed]

Rivera C, Li H, Thomas-Crusells J, Lahtinen H, Viitanen T, Nanobashvili A, Kokaia Z, Airaksinen MS, Voipio J, Kaila K, Saarma M (2002) BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol 159:747-52 [Journal] [PubMed]

Rivera C, Voipio J, Kaila K (2005) Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol 562:27-36 [Journal] [PubMed]

Rivera C, Voipio J, Payne JA, Ruusuvuori E, Lahtinen H, Lamsa K, Pirvola U, Saarma M, Kaila K (1999) The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 397:251-5 [Journal] [PubMed]

Rivera C, Voipio J, Thomas-Crusells J, Li H, Emri Z, Sipilä S, Payne JA, Minichiello L, Saarma M, Kaila K (2004) Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci 24:4683-91 [Journal] [PubMed]

Roberts EL, Chih CP (1998) The pH buffering capacity of hippocampal slices from young adult and aged rats. Brain Res 779:271-5 [PubMed]

Ruusuvuori E, Kirilkin I, Pandya N, Kaila K (2010) Spontaneous network events driven by depolarizing GABA action in neonatal hippocampal slices are not attributable to deficient mitochondrial energy metabolism. J Neurosci 30:15638-42 [Journal] [PubMed]

Sheldon C, Church J (2002) Na+/H+ exchange: molecular regulation to therapeutic development. Clin Invest Med 25:229-32 [PubMed]

Sipilä ST, Huttu K, Soltesz I, Voipio J, Kaila K (2005) Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus. J Neurosci 25:5280-9 [Journal] [PubMed]

Staley KJ (2004) Role of the depolarizing GABA response in epilepsy. Adv Exp Med Biol 548:104-9 [PubMed]

Staley KJ, Mody I (1992) Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol 68:197-212 [Journal] [PubMed]

Staley KJ, Proctor WR (1999) Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol 519 Pt 3:693-712 [PubMed]

Staley KJ, Soldo BL, Proctor WR (1995) Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science 269:977-81 [PubMed]

Swift JL, Godin AG, Doré K, Freland L, Bouchard N, Nimmo C, Sergeev M, De Koninck Y, Wiseman PW, Beaulieu JM (2011) Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells. Proc Natl Acad Sci U S A 108:7016-21 [Journal] [PubMed]

Tamás G, Buhl EH, Somogyi P (1997) Fast IPSPs elicited via multiple synaptic release sites by different types of GABAergic neurone in the cat visual cortex. J Physiol 500 ( Pt 3):715-38 [PubMed]

Tyzio R, Allene C, Nardou R, Picardo MA, Yamamoto S, Sivakumaran S, Caiati MD, Rheims S, Minlebaev M, Milh M, Ferré P, Khazipov R, Romette JL, Lorquin J, Cossart R, Khalilov I, Nehlig A, Cherubini E, Ben-Ari Y (2011) Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate. J Neurosci 31:34-45 [Journal] [PubMed]

Uvarov P, Ludwig A, Markkanen M, Soni S, Hübner CA, Rivera C, Airaksinen MS (2009) Coexpression and heteromerization of two neuronal K-Cl cotransporter isoforms in neonatal brain. J Biol Chem 284:13696-704 [Journal] [PubMed]

Verkman AS, Sellers MC, Chao AC, Leung T, Ketcham R (1989) Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications. Anal Biochem 178:355-61 [PubMed]

Voipio J, Pasternack M, Rydqvist B, Kaila K (1991) Effect of gamma-aminobutyric acid on intracellular pH in the crayfish stretch-receptor neurone. J Exp Biol 156:349-60 [PubMed]

Woodin MA, Ganguly K, Poo MM (2003) Coincident pre- and postsynaptic activity modifies GABAergic synapses by postsynaptic changes in Cl- transporter activity. Neuron 39:807-20 [PubMed]

Yao H, Ma E, Gu XQ, Haddad GG (1999) Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice. J Clin Invest 104:637-45 [Journal] [PubMed]

Buchin A, Chizhov A, Huberfeld G, Miles R, Gutkin BS (2016) Reduced Efficacy of the KCC2 Cotransporter Promotes Epileptic Oscillations in a Subiculum Network Model. J Neurosci 36:11619-11633 [Journal] [PubMed]

   Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016) [Model]

Lombardi A, Jedlicka P, Luhmann HJ, Kilb W (2019) Interactions Between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl-Transport Shape Activity-Dependent Changes of Intracellular Cl- Concentration Int J of Mol Sci, in press

   Factors contribution to GDP-induced [Cl-]i transients (Lombardi et al 2019) [Model]

Ratté S, Prescott SA (2011) ClC-2 channels regulate neuronal excitability, not intracellular chloride levels. J Neurosci 31:15838-43 [Journal] [PubMed]

   ClC-2 channels regulate neuronal excitability, not intracellular Cl- levels (Ratte & Prescott 2011) [Model]

(89 refs)