Citation Relationships



Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, Hudmon A, Cummins TR, Shou W (2012) The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity. J Physiol 590:5123-39 [PubMed]

References and models cited by this paper

References and models that cite this paper

Amin AS, Asghari-Roodsari A, Tan HL (2010) Cardiac sodium channelopathies. Pflugers Arch 460:223-37 [Journal] [PubMed]

An RH, Bangalore R, Rosero SZ, Kass RS (1996) Lidocaine block of LQT-3 mutant human Na+ channels. Circ Res 79:103-8 [PubMed]

Balser JR, Nuss HB, Orias DW, Johns DC, Marban E, Tomaselli GF, Lawrence JH (1996) Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels. J Clin Invest 98:2874-86 [Journal] [PubMed]

Balser JR, Nuss HB, Romashko DN, Marban E, Tomaselli GF (1996) Functional consequences of lidocaine binding to slow-inactivated sodium channels. J Gen Physiol 107:643-58 [PubMed]

Bankston JR, Yue M, Chung W, Spyres M, Pass RH, Silver E, Sampson KJ, Kass RS (2007) A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. PLoS One 2:e1258 [Journal] [PubMed]

Bennett PB, Valenzuela C, Chen LQ, Kallen RG (1995) On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain. Circ Res 77:584-92 [PubMed]

Bennett PB, Yazawa K, Makita N, George AL (1995) Molecular mechanism for an inherited cardiac arrhythmia. Nature 376:683-5 [Journal] [PubMed]

Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anesthesiology 72:711-34 [PubMed]

Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q (1998) Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392:293-6 [Journal] [PubMed]

Clancy CE, Tateyama M, Kass RS (2002) Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. J Clin Invest 110:1251-62 [Journal] [PubMed]

Courtemanche M, Ramirez RJ, Nattel S (1998) Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am J Physiol 275:H301-21 [Journal] [PubMed]

   Cardiac Atrial Cell (Courtemanche et al 1998) [Model]
   Cardiac Atrial Cell (Courtemanche et al 1998) (C++) [Model]

Craelius W, Green WL, Harris DR (1990) Acute effects of thyroid hormone on sodium currents in neonatal myocytes. Biosci Rep 10:309-15 [PubMed]

Dumaine R, Kirsch GE (1998) Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels. Am J Physiol 274:H477-87 [PubMed]

Gaughan JP, Hefner CA, Houser SR (1998) Electrophysiological properties of neonatal rat ventricular myocytes with alpha1-adrenergic-induced hypertrophy. Am J Physiol 275:H577-90 [Journal] [PubMed]

Gellens ME, George AL, Chen LQ, Chahine M, Horn R, Barchi RL, Kallen RG (1992) Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci U S A 89:554-8 [PubMed]

Grant AO, Chandra R, Keller C, Carboni M, Starmer CF (2000) Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. Biophys J 79:3019-35 [Journal] [PubMed]

Hanck DA, Nikitina E, McNulty MM, Fozzard HA, Lipkind GM, Sheets MF (2009) Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. Circ Res 105:492-9 [Journal] [PubMed]

Hedley PL, Jørgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA, Kanters JK, Corfield VA, Christiansen M (2009) The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat 30:1486-511 [Journal] [PubMed]

Hille B (1977) Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69:497-515 [PubMed]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Jarecki BW, Piekarz AD, Jackson JO, Cummins TR (2010) Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents. J Clin Invest 120:369-78 [Journal] [PubMed]

Jarecki BW, Sheets PL, Jackson JO, Cummins TR (2008) Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. J Physiol 586:4137-53 [Journal] [PubMed]

Kass RS (2006) Sodium channel inactivation in heart: a novel role of the carboxy-terminal domain. J Cardiovasc Electrophysiol 17 Suppl 1:S21-S25 [Journal] [PubMed]

Kiyosue T, Arita M (1989) Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circ Res 64:389-97 [PubMed]

Leffler A, Herzog RI, Dib-Hajj SD, Waxman SG, Cummins TR (2005) Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue. Pflugers Arch 451:454-63 [Journal] [PubMed]

Luo CH, Rudy Y (1994) A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ Res 74:1071-96 [PubMed]

   Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++) [Model]

Makita N (2009) Phenotypic overlap of cardiac sodium channelopathies: individual-specific or mutation-specific? Circ J 73:810-7 [PubMed]

Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh H, Kimura T, Kita T, Horie M (2008) A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol 52:1326-34 [Journal] [PubMed]

McNulty MM, Edgerton GB, Shah RD, Hanck DA, Fozzard HA, Lipkind GM (2007) Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels. J Physiol 581:741-55 [Journal] [PubMed]

Meadows LS, Chen YH, Powell AJ, Clare JJ, Ragsdale DS (2002) Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits. Neuroscience 114:745-53 [PubMed]

Patton DE, West JW, Catterall WA, Goldin AL (1992) Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc Natl Acad Sci U S A 89:10905-9 [PubMed]

Ragsdale DS, McPhee JC, Scheuer T, Catterall WA (1996) Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc Natl Acad Sci U S A 93:9270-5 [PubMed]

Remme CA, Wilde AA (2008) SCN5A overlap syndromes: no end to disease complexity? Europace 10:1253-5 [Journal] [PubMed]

Remme CA, Wilde AA, Bezzina CR (2008) Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations. Trends Cardiovasc Med 18:78-87 [Journal] [PubMed]

Rogart RB, Cribbs LL, Muglia LK, Kephart DD, Kaiser MW (1989) Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform. Proc Natl Acad Sci U S A 86:8170-4 [PubMed]

Ruan Y, Denegri M, Liu N, Bachetti T, Seregni M, Morotti S, Severi S, Napolitano C, Priori SG (2010) Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3. Circ Res 106:1374-83 [Journal] [PubMed]

Ruan Y, Liu N, Bloise R, Napolitano C, Priori SG (2007) Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients. Circulation 116:1137-44 [Journal] [PubMed]

Saint DA, Ju YK, Gage PW (1992) A persistent sodium current in rat ventricular myocytes. J Physiol 453:219-31 [PubMed]

Sheets MF, Fozzard HA, Lipkind GM, Hanck DA (2010) Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med 20:16-21 [Journal] [PubMed]

Sheets MF, Hanck DA (2007) Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol 582:317-34 [Journal] [PubMed]

Song Y, Shryock JC, Belardinelli L (2008) An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol 294:H2031-9 [Journal] [PubMed]

Stühmer W, Conti F, Suzuki H, Wang XD, Noda M, Yahagi N, Kubo H, Numa S (1989) Structural parts involved in activation and inactivation of the sodium channel. Nature 339:597-603 [Journal] [PubMed]

Vassilev PM, Scheuer T, Catterall WA (1988) Identification of an intracellular peptide segment involved in sodium channel inactivation. Science 241:1658-61 [PubMed]

Volders PG, Vos MA, Szabo B, Sipido KR, de Groot SH, Gorgels AP, Wellens HJ, Lazzara R (2000) Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc Res 46:376-92 [PubMed]

Wang DW, Desai RR, Crotti L, Arnestad M, Insolia R, Pedrazzini M, Ferrandi C, Vege A, Rognum T, Schwartz PJ, George AL (2007) Cardiac sodium channel dysfunction in sudden infant death syndrome. Circulation 115:368-76 [Journal] [PubMed]

Wang DW, Yazawa K, George AL, Bennett PB (1996) Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome. Proc Natl Acad Sci U S A 93:13200-5 [PubMed]

Wang DW, Yazawa K, Makita N, George AL, Bennett PB (1997) Pharmacological targeting of long QT mutant sodium channels. J Clin Invest 99:1714-20 [Journal] [PubMed]

Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT (1995) SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80:805-11 [PubMed]

Wang SY, Mitchell J, Moczydlowski E, Wang GK (2004) Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway. J Gen Physiol 124:691-701 [Journal] [PubMed]

West JW, Patton DE, Scheuer T, Wang Y, Goldin AL, Catterall WA (1992) A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A 89:10910-4 [PubMed]

Wilde AA, Brugada R (2011) Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ Res 108:884-97 [Journal] [PubMed]

Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T (2010) A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome. Int J Cardiol 145:61-4 [Journal] [PubMed]

(52 refs)