Citation Relationships



Keller D, Babai N, Kochubey O, Han Y, Markram H, Schürmann F, Schneggenburger R (2015) An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse. PLoS Comput Biol 11:e1004253 [PubMed]

   Active zone model of Ca2+ secretion coupling (Keller et al. 2015)

References and models cited by this paper

References and models that cite this paper

Adler EM, Augustine GJ, Duffy SN, Charlton MP (1991) Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse. J Neurosci 11:1496-507 [PubMed]

Augustine GJ, Adler EM, Charlton MP (1991) The calcium signal for transmitter secretion from presynaptic nerve terminals. Ann N Y Acad Sci 635:365-81 [PubMed]

Babai N, Kochubey O, Keller D, Schneggenburger R (2014) An alien divalent ion reveals a major role for Ca²? buffering in controlling slow transmitter release. J Neurosci 34:12622-35 [Journal] [PubMed]

Bollmann JH, Sakmann B (2005) Control of synaptic strength and timing by the release-site Ca2+ signal. Nat Neurosci 8:426-34 [Journal] [PubMed]

Bollmann JH, Sakmann B, Borst JG (2000) Calcium sensitivity of glutamate release in a calyx-type terminal. Science 289:953-7 [PubMed]

Borst JG, Sakmann B (1996) Calcium influx and transmitter release in a fast CNS synapse. Nature 383:431-4 [Journal] [PubMed]

Borst JG, Sakmann B (1998) Calcium current during a single action potential in a large presynaptic terminal of the rat brainstem. J Physiol 506 ( Pt 1):143-57 [PubMed]

Borst JG, Sakmann B (1999) Effect of changes in action potential shape on calcium currents and transmitter release in a calyx-type synapse of the rat auditory brainstem. Philos Trans R Soc Lond B Biol Sci 354:347-55 [Journal] [PubMed]

Bucurenciu I, Kulik A, Schwaller B, Frotscher M, Jonas P (2008) Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse. Neuron 57:536-45 [Journal] [PubMed]

Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R, Matsui K (2013) Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held. J Physiol 591:219-39 [Journal] [PubMed]

Cardona A, Saalfeld S, Preibisch S, Schmid B, Cheng A, Pulokas J, Tomancak P, Hartenstein V (2010) An integrated micro- and macroarchitectural analysis of the Drosophila brain by computer-assisted serial section electron microscopy. PLoS Biol [Journal] [PubMed]

Chad JE, Eckert R (1984) Calcium domains associated with individual channels can account for anomalous voltage relations of CA-dependent responses. Biophys J 45:993-9 [Journal] [PubMed]

Chen Z, Das B, Nakamura Y, DiGregorio DA, Young SM (2015) Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse. J Neurosci 35:2083-100 [Journal] [PubMed]

Choquet D, Triller A (2013) The dynamic synapse. Neuron 80:691-703 [Journal] [PubMed]

Dobrunz LE, Huang EP, Stevens CF (1997) Very short-term plasticity in hippocampal synapses. Proc Natl Acad Sci U S A 94:14843-7 [PubMed]

Dodge FA, Rahamimoff R (1967) Co-operative action a calcium ions in transmitter release at the neuromuscular junction. J Physiol 193:419-32 [PubMed]

Eggermann E, Bucurenciu I, Goswami SP, Jonas P (2011) Nanodomain coupling between Ca²? channels and sensors of exocytosis at fast mammalian synapses. Nat Rev Neurosci 13:7-21 [Journal] [PubMed]

Fedchyshyn MJ, Wang LY (2005) Developmental transformation of the release modality at the calyx of Held synapse. J Neurosci 25:4131-40 [Journal] [PubMed]

Felmy F, Neher E, Schneggenburger R (2003) Probing the intracellular calcium sensitivity of transmitter release during synaptic facilitation. Neuron 37:801-11 [PubMed]

Felmy F, Neher E, Schneggenburger R (2003) The timing of phasic transmitter release is Ca2+-dependent and lacks a direct influence of presynaptic membrane potential. Proc Natl Acad Sci U S A 100:15200-5 [Journal] [PubMed]

Fernández-Busnadiego R, Asano S, Oprisoreanu AM, Sakata E, Doengi M, Kochovski Z, Zürner M, Stein V, Schoch S, Baumeister W, Lucic V (2013) Cryo-electron tomography reveals a critical role of RIM1a in synaptic vesicle tethering. J Cell Biol 201:725-40 [Journal] [PubMed]

Fogelson AL, Zucker RS (1985) Presynaptic calcium diffusion from various arrays of single channels. Implications for transmitter release and synaptic facilitation. Biophys J 48:1003-17 [Journal] [PubMed]

Han Y, Kaeser PS, Südhof TC, Schneggenburger R (2011) RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron 69:304-16 [Journal] [PubMed]

Harlow ML, Ress D, Stoschek A, Marshall RM, McMahan UJ (2001) The architecture of active zone material at the frog's neuromuscular junction. Nature 409:479-84 [Journal] [PubMed]

Helmchen F, Borst JG, Sakmann B (1997) Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. Biophys J 72:1458-71 [Journal] [PubMed]

Holderith N, Lorincz A, Katona G, Rózsa B, Kulik A, Watanabe M, Nusser Z (2012) Release probability of hippocampal glutamatergic terminals scales with the size of the active zone. Nat Neurosci 15:988-97 [Journal] [PubMed]

Kerr RA, Bartol TM, Kaminsky B, Dittrich M, Chang JC, Baden SB, Sejnowski TJ, Stiles JR (2008) FAST MONTE CARLO SIMULATION METHODS FOR BIOLOGICAL REACTION-DIFFUSION SYSTEMS IN SOLUTION AND ON SURFACES. SIAM J Sci Comput 30:3126 [Journal] [PubMed]

Kochubey O, Han Y, Schneggenburger R (2009) Developmental regulation of the intracellular Ca2+ sensitivity of vesicle fusion and Ca2+-secretion coupling at the rat calyx of Held. J Physiol 587:3009-23 [Journal] [PubMed]

Korogod N, Lou X, Schneggenburger R (2005) Presynaptic Ca2+ requirements and developmental regulation of posttetanic potentiation at the calyx of Held. J Neurosci 25:5127-37 [Journal] [PubMed]

Li L, Bischofberger J, Jonas P (2007) Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons. J Neurosci 27:13420-9 [Journal] [PubMed]

Lin KH, Oleskevich S, Taschenberger H (2011) Presynaptic Ca2+ influx and vesicle exocytosis at the mouse endbulb of Held: a comparison of two auditory nerve terminals. J Physiol 589:4301-20 [Journal] [PubMed]

Liu KS, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, Matkovic T, Muhammad K, Depner H, Mettke C, Bückers J, Hell SW, Müller M, Davis GW, Schmitz D, Sigrist SJ (2011) RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science 334:1565-9 [Journal] [PubMed]

Lou X, Scheuss V, Schneggenburger R (2005) Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion. Nature 435:497-501 [Journal] [PubMed]

Masugi-Tokita M, Shigemoto R (2007) High-resolution quantitative visualization of glutamate and GABA receptors at central synapses. Curr Opin Neurobiol 17:387-93 [Journal] [PubMed]

Matveev V, Bertram R, Sherman A (2011) Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap. Brain Res 1398:126-38 [Journal] [PubMed]

Meinrenken CJ, Borst JG, Sakmann B (2002) Calcium secretion coupling at calyx of Held governed by nonuniform channel-vesicle topography. J Neurosci 22:1648-67 [PubMed]

Mercer AJ, Chen M, Thoreson WB (2011) Lateral mobility of presynaptic L-type calcium channels at photoreceptor ribbon synapses. J Neurosci 31:4397-406 [Journal] [PubMed]

Meyer AC, Neher E, Schneggenburger R (2001) Estimation of quantal size and number of functional active zones at the calyx of Held synapse by nonstationary EPSC variance analysis. J Neurosci 21:7889-900 [PubMed]

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U (2010) Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci U S A 107:14950-7 [Journal] [PubMed]

Müller M, Felmy F, Schneggenburger R (2008) A limited contribution of Ca2+ current facilitation to paired-pulse facilitation of transmitter release at the rat calyx of Held. J Physiol 586:5503-20 [Journal] [PubMed]

Müller M, Felmy F, Schwaller B, Schneggenburger R (2007) Parvalbumin is a mobile presynaptic Ca2+ buffer in the calyx of Held that accelerates the decay of Ca2+ and short-term facilitation. J Neurosci 27:2261-71 [Journal] [PubMed]

Murthy VN, Sejnowski TJ, Stevens CF (1997) Heterogeneous release properties of visualized individual hippocampal synapses. Neuron 18:599-612 [PubMed]

Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman JS, Shigemoto R, Silver RA, DiGregorio DA, Takahashi T (2015) Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development. Neuron 85:145-158 [Journal] [PubMed]

Naraghi M, Neher E (1997) Linearized buffered Ca2+ diffusion in microdomains and its implications for calculation of [Ca2+] at the mouth of a calcium channel. J Neurosci 17:6961-73 [PubMed]

Neher E (1998) Usefulness and limitations of linear approximations to the understanding of Ca++ signals. Cell Calcium 24:345-57 [PubMed]

Neher E (2006) A comparison between exocytic control mechanisms in adrenal chromaffin cells and a glutamatergic synapse. Pflugers Arch 453:261-8 [Journal] [PubMed]

Rozov A, Burnashev N, Sakmann B, Neher E (2001) Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics. J Physiol 531:807-26 [PubMed]

Sakaba T, Neher E (2001) Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse. Neuron 32:1119-31 [PubMed]

Sätzler K, Söhl LF, Bollmann JH, Borst JG, Frotscher M, Sakmann B, Lübke JH (2002) Three-dimensional reconstruction of a calyx of Held and its postsynaptic principal neuron in the medial nucleus of the trapezoid body. J Neurosci 22:10567-79 [PubMed]

Schikorski T, Stevens CF (1997) Quantitative ultrastructural analysis of hippocampal excitatory synapses. J Neurosci 17:5858-67 [PubMed]

Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676-82 [Journal] [PubMed]

Schmidt H, Brachtendorf S, Arendt O, Hallermann S, Ishiyama S, Bornschein G, Gall D, Schiffmann SN, Heckmann M, Eilers J (2013) Nanodomain coupling at an excitatory cortical synapse. Curr Biol 23:244-9 [Journal] [PubMed]

Schneggenburger R, Han Y, Kochubey O (2012) Ca(2+) channels and transmitter release at the active zone. Cell Calcium 52:199-207 [Journal] [PubMed]

Schneggenburger R, Neher E (2000) Intracellular calcium dependence of transmitter release rates at a fast central synapse. Nature 406:889-93 [Journal] [PubMed]

Schoch S, Gundelfinger ED (2006) Molecular organization of the presynaptic active zone. Cell Tissue Res 326:379-91 [Journal] [PubMed]

Sheng J, He L, Zheng H, Xue L, Luo F, Shin W, Sun T, Kuner T, Yue DT, Wu LG (2012) Calcium-channel number critically influences synaptic strength and plasticity at the active zone. Nat Neurosci 15:998-1006 [Journal] [PubMed]

Siksou L, Rostaing P, Lechaire JP, Boudier T, Ohtsuka T, Fejtová A, Kao HT, Greengard P, Gundelfinger ED, Triller A, Marty S (2007) Three-dimensional architecture of presynaptic terminal cytomatrix. J Neurosci 27:6868-77 [Journal] [PubMed]

Simon SM, Llinás RR (1985) Compartmentalization of the submembrane calcium activity during calcium influx and its significance in transmitter release. Biophys J 48:485-98 [Journal] [PubMed]

Stanley EF (1993) Single calcium channels and acetylcholine release at a presynaptic nerve terminal. Neuron 11:1007-11 [PubMed]

Stevens CF, Wang Y (1995) Facilitation and depression at single central synapses. Neuron 14:795-802 [PubMed]

Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC (2007) A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature 450:676-82 [Journal] [PubMed]

   A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (Sun et al. 2007) [Model]

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R (2006) Molecular anatomy of a trafficking organelle. Cell 127:831-46 [Journal] [PubMed]

Taschenberger H, Leão RM, Rowland KC, Spirou GA, von Gersdorff H (2002) Optimizing synaptic architecture and efficiency for high-frequency transmission. Neuron 36:1127-43 [PubMed]

Trommershäuser J, Schneggenburger R, Zippelius A, Neher E (2003) Heterogeneous presynaptic release probabilities: functional relevance for short-term plasticity. Biophys J 84:1563-79 [Journal] [PubMed]

Wadel K, Neher E, Sakaba T (2007) The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron 53:563-75 [Journal] [PubMed]

Wang LY, Neher E, Taschenberger H (2008) Synaptic vesicles in mature calyx of Held synapses sense higher nanodomain calcium concentrations during action potential-evoked glutamate release. J Neurosci 28:14450-8 [Journal] [PubMed]

Weber AM, Wong FK, Tufford AR, Schlichter LC, Matveev V, Stanley EF (2010) N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release. Nat Neurosci 13:1348-50 [Journal] [PubMed]

Wölfel M, Lou X, Schneggenburger R (2007) A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse. J Neurosci 27:3198-210 [Journal] [PubMed]

Xu-Friedman MA, Harris KM, Regehr WG (2001) Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neurosci 21:6666-72 [PubMed]

Yang YM, Fedchyshyn MJ, Grande G, Aitoubah J, Tsang CW, Xie H, Ackerley CA, Trimble WS, Wang LY (2010) Septins regulate developmental switching from microdomain to nanodomain coupling of Ca(2+) influx to neurotransmitter release at a central synapse. Neuron 67:100-15 [Journal] [PubMed]

(70 refs)