Citation Relationships

Sundt D, Gamper N, Jaffe DB (2015) Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J Neurophysiol 114:3140-53 [PubMed]

   A model of the T-junction of a C-fiber sensory neuron (Sundt et al. 2015)

References and models cited by this paper

References and models that cite this paper

Amir R, Devor M (1997) Spike-evoked suppression and burst patterning in dorsal root ganglion neurons of the rat. J Physiol 501 ( Pt 1):183-96 [PubMed]

Amir R, Devor M (2000) Functional cross-excitation between afferent A- and C-neurons in dorsal root ganglia. Neuroscience 95:189-95 [PubMed]

Amir R, Devor M (2003a) Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction. Biophys J 84:2181-91 [PubMed]

   Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003) [Model]

Aradi I, Holmes WR (1999) Role of multiple calcium and calcium-dependent conductances in regulation of hippocampal dentate granule cell excitability. J Comput Neurosci 6:215-35 [Journal] [PubMed]

   Dentate gyrus granule cell: calcium and calcium-dependent conductances (Aradi and Holmes 1999) [Model]

Borg-graham L (1987) Modelling the somatic electrical behavior of hippocampal pyramidal neurons Masters Thesis

Bucher D, Goaillard JM (2011) Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon. Prog Neurobiol 94:307-46 [Journal] [PubMed]

Campero M, Serra J, Bostock H, Ochoa JL (2004) Partial reversal of conduction slowing during repetitive stimulation of single sympathetic efferents in human skin. Acta Physiol Scand 182:305-11 [Journal] [PubMed]

Canavier CC (1999) Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci 6:49-69 [Journal] [PubMed]

   Midbrain dopamine neuron: firing patterns (Canavier 1999) [Model]

Chen X, Levine JD (2003) Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat. Neuroscience 121:1007-15 [PubMed]

Chien LY, Cheng JK, Chu D, Cheng CF, Tsaur ML (2007) Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity. J Neurosci 27:9855-65 [Journal] [PubMed]

Choi JS, Waxman SG (2011) Physiological interactions between Na(v)1.7 and Na(v)1.8 sodium channels: a computer simulation study. J Neurophysiol 106:3173-84 [Journal] [PubMed]

Cummins TR, Sheets PL, Waxman SG (2007) The roles of sodium channels in nociception: Implications for mechanisms of pain. Pain 131:243-57 [Journal] [PubMed]

Cummins TR, Waxman SG (1997) Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci 17:3503-14 [PubMed]

Czéh G, Kudo N, Kuno M (1977) Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy. J Physiol 270:165-80 [PubMed]

Debanne D (2004) Information processing in the axon. Nat Rev Neurosci 5:304-16 [PubMed]

Debanne D, Campanac E, Bialowas A, Carlier E, Alcaraz G (2011) Axon physiology. Physiol Rev 91:555-602 [Journal] [PubMed]

Deer TR, Grigsby E, Weiner RL, Wilcosky B, Kramer JM () A prospective study of dorsal root ganglion stimulation for the relief of chronic pain. Neuromodulation 16:67-71; discussion 71-2 [Journal] [PubMed]

Delmas P, Brown DA (2005) Pathways modulating neural KCNQ-M (Kv7) potassium channels. Nat Rev Neurosci 6:850-62 [PubMed]

Djouhri L, Dawbarn D, Robertson A, Newton R, Lawson SN (2001) Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons. J Neurosci 21:8722-33 [PubMed]

Djouhri L, Lawson SN (2001) Differences in the size of the somatic action potential overshoot between nociceptive and non-nociceptive dorsal root ganglion neurones in the guinea-pig. Neuroscience 108:479-91 [PubMed]

Donnelly DF, Panisello JM, Boggs D (1998) Effect of sodium perturbations on rat chemoreceptor spike generation: implications for a Poisson model. J Physiol 511 ( Pt 1):301-11 [PubMed]

Du X, Gamper N (2013) Potassium channels in peripheral pain pathways: expression, function and therapeutic potential. Curr Neuropharmacol 11:621-40 [Journal] [PubMed]

Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, Wang C, Sundt D, Jaffe DB, Zhang H, Gamper N (2014) Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain 155:2306-22 [Journal] [PubMed]

Dubin AE, Patapoutian A (2010) Nociceptors: the sensors of the pain pathway. J Clin Invest 120:3760-72 [Journal] [PubMed]

Fang L, Wu J, Lin Q, Willis WD (2002) Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci 22:4196-204 [Journal] [PubMed]

Fang X, McMullan S, Lawson SN, Djouhri L (2005) Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo. J Physiol 565:927-43 [Journal] [PubMed]

Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma. Nat Neurosci 13:852-60 [Journal] [PubMed]

   Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010) [Model]
   Action potential-evoked Na+ influx similar in axon and soma (Fleidervish et al. 2010) (Python) [Model]

FRANKENHAEUSER B, HODGKIN AL (1956) The after-effects of impulses in the giant nerve fibres of Loligo. J Physiol 131:341-76 [PubMed]

Gao LL, McMullan S, Djouhri L, Acosta C, Harper AA, Lawson SN (2012) Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function. J Physiol 590:4691-705 [Journal] [PubMed]

Gemes G, Koopmeiners A, Rigaud M, Lirk P, Sapunar D, Bangaru ML, Vilceanu D, Garrison SR, Lju (2013) Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury. J Physiol 591:1111-31 [Journal] [PubMed]

Goldstein SS, Rall W (1974) Changes of action potential shape and velocity for changing core conductor geometry. Biophys J 14:731-57 [PubMed]

Ha H (1970) Axonal bifurcation in the dorsal root ganglion of the cat: a light and electron microscopic study. J Comp Neurol 140:227-40 [PubMed]

Hayar A, Gu C, Al-Chaer ED (2008) An improved method for patch clamp recording and calcium imaging of neurons in the intact dorsal root ganglion in rats. J Neurosci Methods 173:74-82 [Journal] [PubMed]

Hayashi H, Iwata M, Tsuchimori N, Matsumoto T (2014) Activation of peripheral KCNQ channels attenuates inflammatory pain. Mol Pain 10:15 [Journal] [PubMed]

Hendry SHC,Hsiao SS,Brown HC (1999) Fundamentals of sensory systems Fundamental Neuroscience, Squire LR, Bloom FE:McConnell SK:Roberts JL:Spitzer NC:Zigmond MJ, ed. pp.657

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hines ML, Carnevale NT (2000) Expanding NEURON's repertoire of mechanisms with NMODL. Neural Comput 12:995-1007 [PubMed]

HODGKIN AL, KEYNES RD (1956) Experiments on the injection of substances into squid giant axons by means of a microsyringe. J Physiol 131:592-616 [PubMed]

Hogan Q, Lirk P, Poroli M, Rigaud M, Fuchs A, Fillip P, Ljubkovic M, Gemes G, Sapunar D (2008) Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons. Anesth Analg 107:1045-51 [Journal] [PubMed]

Hoheisel U, Mense S (1986) Non-myelinated afferent fibres do not originate exclusively from the smallest dorsal root ganglion cells in the cat. Neurosci Lett 72:153-7 [PubMed]

Hoheisel U, Mense S (1987) Observations on the morphology of axons and somata of slowly conducting dorsal root ganglion cells in the cat. Brain Res 423:269-78 [PubMed]

Jaffe DB, Ross WN, Lisman JE, Lasser-Ross N, Miyakawa H, Johnston D (1994) A model for dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on fluorescence imaging measurements. J Neurophysiol 71:1065-77 [Journal] [PubMed]

Keynes RD, Ritchie JM (1965) The movements of labelled ions in mammalian non-myelinated nerve fibres. J Physiol 179:333-67 [PubMed]

Koopmeiners AS, Mueller S, Kramer J, Hogan QH () Effect of electrical field stimulation on dorsal root ganglion neuronal function. Neuromodulation 16:304-11; discussion 310-1 [Journal] [PubMed]

Krames ES (2015) The dorsal root ganglion in chronic pain and as a target for neuromodulation: a review. Neuromodulation 18:24-32; discussion 32 [Journal] [PubMed]

Kress M, Koltzenburg M, Reeh PW, Handwerker HO (1992) Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro. J Neurophysiol 68:581-95 [PubMed]

Kushmerick MJ, Podolsky RJ (1969) Ionic mobility in muscle cells. Science 166:1297-8 [PubMed]

Lancaster B, Pennefather P (1987) Potassium currents evoked by brief depolarizations in bull-frog sympathetic ganglion cells. J Physiol 387:519-48 [PubMed]

Leem JW, Willis WD, Chung JM (1993) Cutaneous sensory receptors in the rat foot. J Neurophysiol 69:1684-99 [PubMed]

Liem L, Russo M, Huygen FJ, Van Buyten JP, Smet I, Verrills P, Cousins M, Brooker C, Levy R, (2015) One-year outcomes of spinal cord stimulation of the dorsal root ganglion in the treatment of chronic neuropathic pain. Neuromodulation 18:41-8; discussion 48-9 [Journal] [PubMed]

Lirk P, Poroli M, Rigaud M, Fuchs A, Fillip P, Huang CY, Ljubkovic M, Sapunar D, Hogan Q (2008) Modulators of calcium influx regulate membrane excitability in rat dorsal root ganglion neurons. Anesth Analg 107:673-85 [Journal] [PubMed]

Long RR (1977) Sensitivity of cutaneous cold fibers to noxious heat: paradoxical cold discharge. J Neurophysiol 40:489-502 [PubMed]

Luscher C, Streit J, Lipp P, Luscher HR (1994) Action potential propagation through embryonic dorsal root ganglion cells in culture. II. Decrease of conduction reliability during repetitive stimulation. J Neurophysiol 72:634-43 [Journal] [PubMed]

Luscher C, Streit J, Quadroni R, Luscher HR (1994) Action potential propagation through embryonic dorsal root ganglion cells in culture. I. Influence of the cell morphology on propagation properties. J Neurophysiol 72:622-33 [Journal] [PubMed]

Manor Y, Koch C, Segev I (1991) Effect of geometrical irregularities on propagation delay in axonal trees. Biophys J 60:1424-37 [PubMed]

Matsumoto E, Rosenbluth J (1985) Plasma membrane structure at the axon hillock, initial segment and cell body of frog dorsal root ganglion cells. J Neurocytol 14:731-47 [PubMed]

Migliore M, Cook EP, Jaffe DB, Turner DA, Johnston D (1995) Computer simulations of morphologically reconstructed CA3 hippocampal neurons. J Neurophysiol 73:1157-68 [Journal] [PubMed]

   CA3 Pyramidal Neuron (Migliore et al 1995) [Model]

Neishabouri A, Faisal AA (2014) Saltatory conduction in unmyelinated axons: clustering of Na(+) channels on lipid rafts enables micro-saltatory conduction in C-fibers. Front Neuroanat 8:109 [Journal] [PubMed]

Obreja O, Ringkamp M, Namer B, Forsch E, Klusch A, Rukwied R, Petersen M, Schmelz M (2010) Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human. Pain 148:59-69 [Journal] [PubMed]

Passmore GM, Reilly JM, Thakur M, Keasberry VN, Marsh SJ, Dickenson AH, Brown DA (2012) Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings. Front Mol Neurosci 5:63 [Journal] [PubMed]

Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA, Dickenson AH, Brown T (2003) KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci 23:7227-36 [PubMed]

Pope JE, Deer TR, Kramer J (2013) A systematic review: current and future directions of dorsal root ganglion therapeutics to treat chronic pain. Pain Med 14:1477-96 [Journal] [PubMed]

Raymond SA, Thalhammer JG, Popitz-Bergez F, Strichartz GR (1990) Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Res 526:318-21 [PubMed]

Rose K, Ooi L, Dalle C, Robertson B, Wood IC, Gamper N (2011) Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain 152:742-54 [Journal] [PubMed]

Rose KE, Gigout S, Gamper N (2013) M-Current Recording from Acute DRG Slices. Methods Mol Biol 998:311-20 [Journal] [PubMed]

Sasaki T (2013) The axon as a unique computational unit in neurons. Neurosci Res 75:83-8 [Journal] [PubMed]

Sheets PL, Jackson JO, Waxman SG, Dib-Hajj SD, Cummins TR (2007) A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol 581:1019-31 [PubMed]

Slugg RM, Meyer RA, Campbell JN (2000) Response of cutaneous A- and C-fiber nociceptors in the monkey to controlled-force stimuli. J Neurophysiol 83:2179-91 [PubMed]

Stoney SD (1985) Unequal branch point filtering action in different types of dorsal root ganglion neurons of frogs. Neurosci Lett 59:15-20 [PubMed]

Stoney SD (1990) Limitations on impulse conduction at the branch point of afferent axons in frog dorsal root ganglion. Exp Brain Res 80:512-24 [PubMed]

Suh YS, Chung K, Coggeshall RE (1984) A study of axonal diameters and areas in lumbosacral roots and nerves in the rat. J Comp Neurol 222:473-81 [Journal] [PubMed]

Tigerholm J, Petersson ME, Obreja O, Lampert A, Carr R, Schmelz M, Fransén E (2014) Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors. J Neurophysiol 111:1721-35 [Journal] [PubMed]

Traub RD, Wong RK, Miles R, Michelson H (1991) A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J Neurophysiol 66:635-50 [Journal] [PubMed]

Villiere V, McLachlan EM (1996) Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration. J Neurophysiol 76:1924-41 [Journal] [PubMed]

Waddell PJ, Lawson SN, McCarthy PW (1989) Conduction velocity changes along the processes of rat primary sensory neurons. Neuroscience 30:577-84 [PubMed]

Waxman SG, Cummins TR, Dib-Hajj SD, Black JA () Voltage-gated sodium channels and the molecular pathogenesis of pain: a review. J Rehabil Res Dev 37:517-28 [PubMed]

Waxman SG, Zamponi GW (2014) Regulating excitability of peripheral afferents: emerging ion channel targets. Nat Neurosci 17:153-63 [Journal] [PubMed]

Yamada WM, Koch C, Adams PR (1998) Multiple channels and calcium dynamics. Methods In Neuronal Modeling: From Synapses To Networks, Koch C:Segev I, ed. pp.137

Yeomans DC, Pirec V, Proudfit HK (1996) Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence. Pain 68:133-40 [PubMed]

Yeomans DC, Proudfit HK (1996) Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence. Pain 68:141-50 [PubMed]

Zhang JM, Donnelly DF, LaMotte RH (1998) Patch clamp recording from the intact dorsal root ganglion. J Neurosci Methods 79:97-103 [PubMed]

Zheng Q, Fang D, Liu M, Cai J, Wan Y, Han JS, Xing GG (2013) Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain 154:434-48 [Journal] [PubMed]

Zhou L, Chiu SY (2001) Computer model for action potential propagation through branch point in myelinated nerves. J Neurophysiol 85:197-210 [Journal] [PubMed]

Mandge D, Manchanda R (2018) A biophysically detailed computational model of urinary bladder small DRG neuron soma PLOS Computational Biology [Journal] [PubMed]

   Computational model of bladder small DRG neuron soma (Mandge & Manchanda 2018) [Model]

(84 refs)